Local micro environmental factors are crucial in determining both susceptibility to vascular remodeling and the extent of angiogenesis. Major exogenous triggers of airway inflammation in asthma include viruses and inhaled aeroallergens, both of which are known to be associated with the production of angiogenic factors . These stimuli elicit reciprocal immune responses, through elaboration of Th1 and Th2 cytokines. (more…)
Vascular Endothelial Growth Factor (VEGF), originally described as a vascular permeability factor generating tissue oedema, has be ...
The airway circulation has many potential roles in asthma. The vasculature has a major influence on upper airway patency in nasal i ...
Exacerbations of asthma are frequently associated with rhinoviral infection. Rhinoviruses infect respiratory epithelial cells, ...
While our primary concern is the impact that the innate immune system has on allergic disease, it is essential to recognize that al ...
Eosinophil infiltration of the mucosa is a feature of asthmatic airways. Their adhesion to bronchial epithelial cells has been ...
Up to 85% of asthmatics patients have symptoms of wheezing during or after exercise. Moreover, many patients diagnosed with allergies or asthma have family allergy history and bronchospasm. Bronchospasm or a bronchial spasm is a sudden constriction of the muscles in the walls of the bronchioles. Bronchospasm is one of the condition or tightness of the airways caused by exercise. (more…)
Exercise-induced asthma is a feeling of shortness of breath, with the presence of cough, wheezing, and chest tightness after physic ...
It is widely knowt that pollen, pollution, smoke can trigger an asthma attack. But one interesting thing is exercise can also trigg ...
A history of cough, dyspnea, wheezing, chest tightness or performance problems during exercise suggests the person may have Exercis ...
Asthma treatment has one main goal to maintain a normal and healthy lifestyle, including exercise and other physical activities. Pe ...
This article focuses on symptoms of exercise induced asthma. Exercise can be a trigger factor when asthma is not well control ...
While our primary concern is the impact that the innate immune system has on allergic disease, it is essential to recognize that allergic disease also impacts on the function- ing of the innate immune system. In part this is through treatment, since immunosuppressive therapies inevitably contribute to impairment of immunity at the levels of the innate and adaptive systems. (more…)
Innate immune responses are seen in a very broad range of tissues. Indeed, the Toll-like receptors (TLRs, one of the most important ...
Innate immunity depends on both resident and recruited leukocytes. The macrophage without doubt plays an import- ant role in the de ...
Contact of pathogens with the innate immune system will most frequently occur at epithelia, and the biology of the airway epitheliu ...
Activation of the innate immune system is an integral part of the pathology of allergic diseases such as asthma, with a dual role t ...
Exacerbations of asthma are frequently associated with rhinoviral infection. Rhinoviruses infect respiratory epithelial cells, ...
Drugs used for asthma can be divided broadly into two categories:
Drugs that relieve the muscle spasm in the wind pipe (bronchodilators)
Beta agonists
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These drugs are very useful to relieve the asthma attack symptoms. There are two types in this category short acting and long acting beta agonists. (more…)
Two long-acting ß 2 -adrenergic agonists (LABAs), salmeterol and formoterol, have been demonstrated to be safe and effective ag ...
Current internationally recognized guidelines indicate that symptomatic asthmatics using a low to medium inhaled corticosteroid ...
It is important that you understand what asthma medicine to flare up so that you can treat your asthma. Knowing how to control ...
Leukotrienes can be found in the airway and urine following both spontaneous exacerbations of asthma and acute exposure to bron ...
Regular use of ß-agonists has been known to lead to tolerance to their bronchodilator effects. It is not known how quickly toleranc ...