The immunologic mechanisms of sublingual immunotherapy are less established. In Cochrane analysis, the authors concluded that there was an increase in IgG4 but no stable effect on IgE levels in adults. In addition, the induction of allergen-specific IgA has been reported. There are conflicting data concerning lympho-proliferative responses. So far the evidence on changes in Th1/Th2/Treg activity induced by sublingual immunotherapy need to be confirmed. The effects on T-cell reactivity and cytokine secretion show strong variation in a number of studies. (more…)
Allergen-specific immunotherapy aims to correct the underlying immune imbalance associated with specific immunotherapy allergic rhi ...
The precise mechanisms underlying the effects of Specific Immunotherapy are not well understood but several studies have shown ...
The increasing prevalence of allergic disease in the Western world has led to the concept of the ‘allergic march’ to describe t ...
Allergen-specific immunotherapy is highly effective in the treatment of IgE-mediated allergy diseases such as rhinitis, conjunc ...
Histamine is a low-molecular-weight monoamine that binds to four different G-protein-coupled receptors, and has recently been d ...
Treg cells or regulatory T cells constitute a large population of cellular infiltrate in atopic/allergic inflammation and a dysregulated immune response appears to be an important pathogenetic factor. Cardinal events during allergic inflammation can be classified as activation, organ-selective homing, survival and reactivation, and effector functions of immune system cells. T cells are activated by aeroallergens, food antigens, autoantigens, and bacterial exotoxins superantigens in allergic inflammation. They are under the influence of the skin, lung, or nose-related chemokine network and show organ-selective homing. (more…)
Allergen-specific immunotherapy is highly effective in the treatment of IgE-mediated allergy diseases such as rhinitis, conjunc ...
The induction of immune tolerance and specific immune suppression are essential processes in the control of immune responses. R ...
The intracellular forkhead winged transcription factor Foxp3 (forkhead box P3) appears to be specifically expressed by naturall ...
An emerging concept is that pro-inflammatory signals lead to loss of Regulatory T Cells (Treg) function. Pasare and Medzhitov ( ...
Regulatory T cells Treg (picture above) is the existence of suppressor cells, which limit ongoing immune responses and prevent ...
Allergen-specific immunotherapy aims to correct the underlying immune imbalance associated with specific immunotherapy allergic rhinitis, asthma, and systemic reactions to insect stings. Conventional allergen-specific immunotherapy has proven low dose allergen therapy-related efficacy in these disorders; (more…)
Allergen-specific immunotherapy is highly effective in the treatment of IgE-mediated allergy diseases such as rhinitis, conjunc ...
It is now almost a century since the pioneering work of Noon and Freeman was used to successfully treat hay fever symptoms usin ...
The increasing prevalence of allergic disease in the Western world has led to the concept of the ‘allergic march’ to describe t ...
The precise mechanisms underlying the effects of Specific Immunotherapy are not well understood but several studies have shown ...
The specific treatment of allergy has previously relied upon allergen avoidance and sublingual immunotherapy. These approaches have ...
Treatment of allergic diseases in childhood presents unique challenges, as both the beneficial effects and the detrimental effects of intervention(s) may last for decades and even for a lifetime. Most allergic diseases are managed in a community setting by primary care physicians, rather than in a hospital setting by allergy specialists. Here, we describe outpatient treatment, which is focused on prevention and relief of morbidity from allergic diseases and on the identification of children at high risk (more…)
Allergen-specific immunotherapy aims to correct the underlying immune imbalance associated with specific immunotherapy allergic rhi ...
Expert GA ² LEN, the Global Network European Allergy and Asthma European Academy of Allergy and Clinical Immunology, EAACI, warn th ...
Specific immunotherapy has been widely used to treat allergic rhinitis symptoms. As with any other form of specific immunotherapy, ...
Allergic rhinitis is a very common problem associated with poor quality of life, reductions in social and work activities and p ...
Many kids’ deaths in the United States over the years happened both in schools and children camps because of lack of access to ...
Specific immunotherapy has been widely used to treat allergic rhinitis symptoms. As with any other form of specific immunotherapy, careful patient selection is crucial. The diagnosis of allergic rhinitis needs to be secure, especially in those with perennial symptoms, and should be based on a careful clinical history supported by documentation of IgE-mediated sensitivity by skin prick test or blood tests. (more…)
About twenty percent of patients who have common allergic rhinitis are also having perennial allergic rhinitis symptoms. This f ...
Allergen-specific immunotherapy aims to correct the underlying immune imbalance associated with specific immunotherapy allergic rhi ...
Allergic rhinitis is a very common problem associated with poor quality of life, reductions in social and work activities and p ...
It is now almost a century since the pioneering work of Noon and Freeman was used to successfully treat hay fever symptoms usin ...
Allergic rhinitis is a high-prevalence disease. This high prevalence translates into a high cost to society in terms of overall ...