Being an immunological disease, the characteristics of allergy are those of specificity and memory. Regardless of whether the clinical manifestation is rhinoconjunctivitis, rhinitis, or asthma, the underlying immunological response disorder is based on the adverse reactions of cells in the immune system upon contact with allergens. These cells are specific for epitopes that are structural parts of allergens present in the allergenic source material. Two types of cells (i.e., T cells and B-cells) produce receptor molecules (i.e., T-cell receptors and immunoglobulin [IgE] antibodies) that, through high-affinity interactions with the allergen, efficiently catalyze the presence of even minute amounts of allergens into clinical symptoms, the extreme consequence of which may be life-threatening to the patient. (more…)
Allergen vaccines are complex mixtures of antigenic components produced by the extraction of naturally occurring source materia ...
The production of allergen vaccines imposes a number of constraints on both the selection of source materials and the physicoch ...
The quality of an allergen vaccine is a measure of the complexity of the composition, including the concentration of the variou ...
The potency of an allergen vaccine is the total allergen activity (that is, the sum of the contribution to allergenic activity from ...
Having determined an adequate potency and complexity in composition, an allergen vaccine may still be deficient in the content of m ...
First-generation, relatively sedating oral H1 antihistamines such as diphenhydramine and chlorpheniramine have no role in the out-of-hospital management of children with allergic rhinitis diseases. Most of the older H1 antihistamines, although available in palatable liquid formulations, have not been optimally studied in infants or allergy in children. (more…)
Avoidance of respiratory irritants such as environmental tobacco smoke, whether actively or passively inhaled, is universally recom ...
Expert GA ² LEN, the Global Network European Allergy and Asthma European Academy of Allergy and Clinical Immunology, EAACI, warn th ...
As a person who suffered form allergies and have a profession as family physician, I have much sympathy for those struggling with i ...
Indoor allergy is generally happens throughout the year and especially in children as they are the most victims of this type of ...
Antihistamines have been shown to be effective in seasonal allergic rhinitis and chronic idiopathic urticaria. They improve qua ...
Treatment of allergic diseases in childhood presents unique challenges, as both the beneficial effects and the detrimental effects of intervention(s) may last for decades and even for a lifetime. Most allergic diseases are managed in a community setting by primary care physicians, rather than in a hospital setting by allergy specialists. Here, we describe outpatient treatment, which is focused on prevention and relief of morbidity from allergic diseases and on the identification of children at high risk (more…)
Allergen-specific immunotherapy aims to correct the underlying immune imbalance associated with specific immunotherapy allergic rhi ...
Expert GA ² LEN, the Global Network European Allergy and Asthma European Academy of Allergy and Clinical Immunology, EAACI, warn th ...
Specific immunotherapy has been widely used to treat allergic rhinitis symptoms. As with any other form of specific immunotherapy, ...
Allergic rhinitis is a very common problem associated with poor quality of life, reductions in social and work activities and p ...
Many kids’ deaths in the United States over the years happened both in schools and children camps because of lack of access to ...