It is clear from the results of large epidemiologic studies that while atopy is a major risk factor for asthma, it is usually not sufficient by itself to drive the disease process to chronicity, as less than 25% of atopics develop persistent asthma. The situation in childhood is further complicated by an additional series of development factors, related to postnatal maturation of respiratory function. (more…)
In the Tucson CRS study, about 50% of young children experienced a period of recurrent wheezing and/or coughing in the first 6 ...
Natural history studies with the following design features provide a firm epidemiologic foundation for risk factor assessments and ...
Atopic Dermatitis is considered to be one of the first manifestations in the atopic march. The aim of this study was to investi ...
Asthma is a complex syndrome rather than a single disease entity. Different phenotypes with varying prognosis and determinants have ...
More severe asthma can persist from childhood into adulthood without remission. Another important tendency in the natural histo ...
Asthma is a continuing problem for healthcare, particularly in the industrialized world. Some 150 million people are estimated to suffer from asthma worldwide, with 5.2 million sufferers in the UK. Hospital admissions for asthma number 69 000 per annum in the UK, including 28 500 children. Approximately 1400 people die from asthma in the UK annually, of whom over 30% are under the age of 65. Asthma costs the UK National Health Service almost £90 million per annum (statistics from Asthma UK, http://www.asthma.org.uk). (more…)
Vascular Endothelial Growth Factor (VEGF), originally described as a vascular permeability factor generating tissue oedema, has be ...
Airway hyper-responsiveness in asthma may involve smooth muscle growth, a manifestation of airway remodelling. The involvement ...
Airway remodelling is considered to be of major importance in the pathology of asthma, with subepithelial basement membrane thi ...
Contact of pathogens with the innate immune system will most frequently occur at epithelia, and the biology of the airway epitheliu ...
Some features seem to be common to severe asthma and Chronic Obstructive Pulmonary Disease with reversibility of airflow limita ...