Asthma Genetic and Gene-Environment Interaction in Asthma Development

asthma genetics
The genetic basis of asthma heritability has been extensively studied and the studies are yielding some understanding. There is, as yet, no set genetic pattern that predicts presence of asthma or defines it severity. There are usually reasons or risk of asthma factors that makes someone susceptible to asthma and respiratory allergy problems. Asthma doesn’t just happen randomly to anyone without asthma gene factors risk factors.

Let’s consider some asthma risk factors and see how they increase the chance that a individual will have the asthma signs or symptoms of cough, wheezing, as well as shortness of breathing associated with the disease. After determining your personal risk factors for asthma, decide on the ones you can control as well as try to make some lifestyle changes. Avoidance of the risk factors you can control is important in preventing asthma symptoms. While you cannot change your own gender to family history, you can avoid smoking with asthma, breathing polluted air, and obesity. Take control of your asthma by controlling the asthma risk factors. By understanding all of the risk factors, you are able to prevent to control your asthma.

Genetic factors cannot explain the rise in asthma prevalence, morbidity, or mortality. However, a small change in the prevalence of relevant environmental exposures could explain a significant rise in disease prevalence among genetically susceptible individuals. Gene-environment interaction, defined as the co-participation of genetic and environmental factors, is particularly relevant to the etiology of asthma morbidity, especially in individuals who experience a disproportionate burden of environmental exposures. Relevant exposures include smoking, stress, nutritional factors, infections, allergens, and occupational asthma exposures. In addition, racial/ethnic variability in the distribution of genetic polymorphisms can potentially modify the response to pharmacotherapeutic agents, such as the ß 2 -adrenergic receptor. A genetic polymorphism in the ß 2 -adrenergic receptor gene has been associated with asthma severity, as well as with the susceptibility to develop asthma among individuals who smoked.

Childhood asthma happens more frequently in boys than in girls. It is still not known precisely why this occurs even though some experts find a young male’s airway size is small compared to the female’s airway, that may contribute to increased risk of wheezing after a cold or perhaps other viral infection. Around age 20, the ratio of asthma between people is the same. At age 40, more females than men have adult asthma.

The inherited genetic makeup predisposes you to having asthma. In fact, it’s thought that three-fifths of all asthma cases are hereditary. Based on CDC report, if a person has a parent with asthma, there is 3 to 6 times more probably to develop asthma than someone who does definitely not have a parent with asthma.

Allergy History: How to Determine Allergic Problem in Patients

Allergy History Problem
The most crucial element in the assessment process of a possible allergic problem is patient’s allergy history. An allergy history is made up of a chief problem, resolve of seasonality or diurnal variation of symptoms, detection of triggers, occupational asthma exposure, and reaction to medicines, family history, and some other relevant medical history. An allergy history looks for to define the patient’s chief complaint(s) and concentrates on the details with regards to those complaints. There is a lexicon typical to patients with allergy complaints. Sinus dizziness strain and headaches are often cited as symptoms. The history taker should be attuned to the patient’s viewpoint as a possible allergy sufferer. Exactly where and when does the symptom happen? Or is it happened during sleep? (more…)

One in Seven Severe Asthma Attacks is Related to Work

asthma attacks work
Exposure to different gases air pollutants and substances at work is responsible for about one in seven of severe asthma attacks suffered by people of working age, according to a study just published. (more…)

Drug Allergy Reaction Classification – Immune Reactions

drug allergy reaction
Drug allergy reactions may be classified, at least theoretically, according to one of four implicated immunologic mechanisms, according to the scheme of Gell and Coombs:

Type I Drug Allergy Reactions

Type I reactions are the result of an IgE antibody reaction, which induces immediate-type hypersensitivity reactions. (more…)

Perennial Allergic Rhinitis Symptoms

perennial allergic rhinitis
About twenty percent of patients who have common allergic rhinitis are also having perennial allergic rhinitis symptoms. This fact is also reflected in their patterns of drugs and medication use. Compare to seasonal allergic rhinitis, perennial allergic rhinitis patients have significantly higher health care costs and rates of comorbidities and greater use of concomitant medical treatment. (more…)

Occupational Asthma Caused by Work Related Environment

work related asthma
Do you have occupational asthma or the condition where your asthma is triggered or even worsen when you are in your office or job? You are not alone in this situation. More than 10 million workers are exposed to allergens agents in their work environment, based on data from the Occupational Safety & Health Administration. Occupational asthma or work asthma or workplace asthma related to job/work is about 15 % from all kind of asthma altogether. Are you one of them? (more…)