Marimastat is a synthetic broad-spectrum matrix metalloproteinase (MMP) inhibitor. This study assessed the anti-inflammatory effects of marimastat in patients with asthma by reducing TNF-aa production in vivo by inhibiting MMP activity and hence TNF-aa release. The primary aim of the study was to investigate the effects of this MMP inhibitor on allergen-induced hyper-reactivity. The study was designed as a double-blind, placebo-controlled, randomized crossover trial. (more…)
Tumour Necrosis Factor is a pro-inflammatory cytokine implicated in the pathogenesis of asthmatic airway inflammation, hyper-react ...
Roflumilast is an oral, once-daily inhibitor of phosphodiesterase type 4 (PDE4) that prevents the breakdown of cyclic adenosine ...
In asthma, the secretory phospholipases A2 (sPLA2) have been implicated in the release of arachidonic acid from cellular membra ...
IgE plays an important role in allergic asthma. Reducing IgE in the airway mucosa should reduce airway inflammation. Omalizumab has ...
Tumour necrosis factor alpha (TNF-a) is a major therapeutic target in a range of chronic inflammatory disorders involving neutr ...
Asthma is a big problem worldwide today. Many people who suffer from asthma do not even realize they have it until it gets out of control. They might go to the doctor with some respiratory problems and receive temporary asthma relief just to have it come back again because they were not properly diagnosed. Understanding the symptoms of asthma is vital so that you can get proper treatment for it. (more…)
Sinusitis is one inconvenience disease condition that many people had. Many drugs and antibiotics that are prescribed by your docto ...
Asthma can be worsen if it is not treated properly. If you are one of the person who are having such illness, you already knew ...
Allergies can be extremely frustrating and attack at the worst possible times. While doctors may prescribe medication to those ...
There is a lot of prescription drug usage occurring these days, and with those prescription medications, come dangerous side ef ...
Homeopathy treatment is gaining wider acceptance recently. You may look at this natural medication by trying homeopathy to help ...