Innate immunity depends on both resident and recruited leukocytes. The macrophage without doubt plays an import- ant role in the detection of pulmonary infections. Low inocula of pneumococci are cleared by macrophages. Alveolar macrophages also have an important role in the initiation of responses to inhaled lipopolysaccharide (LPS) and their function (more…)
Innate immune responses are seen in a very broad range of tissues. Indeed, the Toll-like receptors (TLRs, one of the most important ...
Contact of pathogens with the innate immune system will most frequently occur at epithelia, and the biology of the airway epitheliu ...
While our primary concern is the impact that the innate immune system has on allergic disease, it is essential to recognize that al ...
Activation of the innate immune system is an integral part of the pathology of allergic diseases such as asthma, with a dual role t ...
Toll-like receptors (TLRs) act as receptors for numerous stimuli of immune cells, including bacterial cell wall constituents (l ...
Nerve fibers containing a variety of neuropeptides, including substance P and CGRP, have been demonstrated in human skin. Intradermal injection of substance P results in an immediate wheal-and-flare reaction , whereas the main effect of CGRP is a long-lasting (4–6 hours) intense erythema. Additionally, CGRP potentiates edema formation evoked by mediators such as substance P. (more…)
After nasal allergen challenge, substance P and CGRP are released into nasal secretions of atopic patients . In allergic rhinit ...
The immunologic mechanisms of sublingual immunotherapy are less established. In Cochrane analysis, the authors concluded that t ...
The potency of an allergen vaccine is the total allergen activity (that is, the sum of the contribution to allergenic activity from ...
Allergy skin testing is probably the most susceptible and practical way to monitor for existing allergy sensitivity. Biological ...
The sensory neuropeptides substance P and neurokinin A (NKA) are members of the tachykinin family, present within pulmonary sensory ...
After nasal allergen challenge, substance P and CGRP are released into nasal secretions of atopic patients . In allergic rhinitis patients, but not in normal control subjects, exogenous substance P induces nasal obstruction. (more…)
Treatment with omalizumab has been shown to reduce serum free IgE concentrations and to have beneficial effects on allergic airway ...
Nerve fibers containing a variety of neuropeptides, including substance P and CGRP, have been demonstrated in human skin. Intra ...
This method of Acoustic Rhinometry is performed by doing the cross-sectional areas of the nasal measures by sending a sound pulse t ...
Allergic rhinitis is an inflammatory nasal disorder in which a range of different cells participate. A variety of approaches ha ...
Spring has finally arrived. With it comes many form of spring allergies. I am a victim of the year along of and spring allergies. F ...