Negative family characteristics such as family conflict and family dysfunction discriminated children who died of asthma from children with equally severe asthma who did not die. Parenting difficulties have been associated with a higher risk for the development of asthma early in life. In addition, children with the highest risk of developing early-onset asthma were those in families with both parenting problems and high stress. Evidence for a asthma and stress link has been demonstrated through temporal studies, as experiencing an acute negative life event increased children’s risk for an asthma attack 4 to 6 weeks after the occurrence of the event. (more…)
Learning to relax is important not only to release tension or stress but can ease your sinus and help you to copy with it. True rel ...
The two strongest risk factors for asthma in childhood are a family history and immediate hypersensitivity to common allergens. ...
Asthma is a frightening condition. I have lived with asthma symptoms for 17 years and the thought of an allergy induced asthma atta ...
Acupuncture for acne, psoriasis, allergies and related conditions is the current interest of several study groups, to investigate a ...
The genetic basis of asthma heritability has been extensively studied and the studies are yielding some understanding. There is ...
Marimastat is a synthetic broad-spectrum matrix metalloproteinase (MMP) inhibitor. This study assessed the anti-inflammatory effects of marimastat in patients with asthma by reducing TNF-aa production in vivo by inhibiting MMP activity and hence TNF-aa release. The primary aim of the study was to investigate the effects of this MMP inhibitor on allergen-induced hyper-reactivity. The study was designed as a double-blind, placebo-controlled, randomized crossover trial. (more…)
Tumour Necrosis Factor is a pro-inflammatory cytokine implicated in the pathogenesis of asthmatic airway inflammation, hyper-react ...
Roflumilast is an oral, once-daily inhibitor of phosphodiesterase type 4 (PDE4) that prevents the breakdown of cyclic adenosine ...
In asthma, the secretory phospholipases A2 (sPLA2) have been implicated in the release of arachidonic acid from cellular membra ...
IgE plays an important role in allergic asthma. Reducing IgE in the airway mucosa should reduce airway inflammation. Omalizumab has ...
Tumour necrosis factor alpha (TNF-a) is a major therapeutic target in a range of chronic inflammatory disorders involving neutr ...
Activation of the innate immune system is an integral part of the pathology of allergic diseases such as asthma, with a dual role that has different emphases in disease initiation and disease perpetuation. Sadly underappreciated in the past, the resurgence in interest in innate immunobiology has been spearheaded by the identification of the TLR system and its huge contribution to health and disease. (more…)
Innate immunity depends on both resident and recruited leukocytes. The macrophage without doubt plays an import- ant role in the de ...
Contact of pathogens with the innate immune system will most frequently occur at epithelia, and the biology of the airway epitheliu ...
While our primary concern is the impact that the innate immune system has on allergic disease, it is essential to recognize that al ...
Innate immune responses are seen in a very broad range of tissues. Indeed, the Toll-like receptors (TLRs, one of the most important ...
Toll-like receptors (TLRs) act as receptors for numerous stimuli of immune cells, including bacterial cell wall constituents (l ...