Scleroderma is a disease of unknown cause characterized by abnormally increased collagen deposition in the skin. The course is usually slowly progressive and chronically disabling, but it can be rapidly progressive and fatal because of involvement of internal organs. It commonly begins in the third or fourth decade of life, but children are occasionally affected. The prevalence of the disease is one case per 100,000 in the population. Women are affected twice as often as men. There is no racial predisposition. (more…)
Scleroderma is a disease related with body autoimmune, connective tissue disease. Scleroderma induces inflammation and thickeni ...
Acute phase proteins are plasma proteins, the synthesis and the circulating concentrations of which are adaptively regulated in res ...
Vascular Endothelial Growth Factor (VEGF), originally described as a vascular permeability factor generating tissue oedema, has be ...
Drug allergy reactions may be classified, at least theoretically, according to one of four implicated immunologic mechanisms, a ...
Definitions of anaphylaxis vary considerably, impeding the comparison of different clinical studies. Different definitions of a ...
Natural killer cells: history and current status
Natural killer cells are a major component of the immune system, which play important roles in host defense against cancer and microbial infections. Natural killer cells are distinct from T or B lymphocytes, with a characteristic morphology of large granular cells, and can be readily identified by characteristic cell surface molecules. (more…)
The body's innate resistance to many pathogens is provided by enzymes and other proteins in the blood and tissue fluids. These ...
Innate immunity depends on both resident and recruited leukocytes. The macrophage without doubt plays an import- ant role in the de ...
Some of the immediate sequelae of injury are uncomfortably familiar: Soon after an injury occurs, the affected site and its sur ...
Regulatory T cells Treg (picture above) is the existence of suppressor cells, which limit ongoing immune responses and prevent ...
Contact of pathogens with the innate immune system will most frequently occur at epithelia, and the biology of the airway epitheliu ...