This study examined the genetic basis of sensitization to house dust mite allergy allergens. A genome scan was conducted using 603 microsatellite markers in 82 nuclear families (366 individuals) of German, British and Portuguese origin with at least two affected siblings. Sensitization to Dermatophagoides pteronyssinus was assessed by determining specific IgE antibody levels detected by immunochemiluminometric assay and immunosorbent assay and categorized as positive or negative relative to a predetermined cut-off point. (more…)
Allergen-specific immunotherapy aims to correct the underlying immune imbalance associated with specific immunotherapy allergic rhinitis, asthma, and systemic reactions to insect stings. Conventional allergen-specific immunotherapy has proven low dose allergen therapy-related efficacy in these disorders; (more…)
The precise mechanisms underlying the effects of Specific Immunotherapy are not well understood but several studies have shown that Specific Immunotherapy T inhibits both early and late immune responses to allergen exposure.
Recently, there have been many studies aimed at elucidating the mechanisms by which allergen-specific immunotherapy works. (more…)
Our current knowledge for trigger factor and food allergy intolerance is still in it infancy level. We already known that the allergic intolerance are different for groups of people. Some individuals are less resistant in developing allergy than others. Allergic sensitivity or atopic allergic disease are heritable and this means that genetic factors is playing a critical role. But the latest researches reveal that it is not merely heredity factors, environmental also have significant impact for someone to develop allergy.
Allergy trigger in the form of food allergen are mostly fallen to some certain foods like milk, egg, peanuts, fish, soya and nuts. We are curios on what is so peculiar about allergens in food? (more…)
Recently, UK Department of Health has circulated advice aimed at reducing the development of peanut allergy. The advice, based on an expert-committee report, is that pregnant women “may wish” to avoid eating peanuts or foods containing peanut products if they or the father or siblings of the unborn child are atopic. The same advice is given for the lactation period.
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