Normally present at very low levels in plasma, antibodies of the immunoglobulin E (IgE) isotype were first discovered in 1967, decades after the description of IgA, IgG, and IM. IgE antibodies are produced primarily by plasma cells in mucosal-associated lymphoid tissue and their levels are uniformly elevated in patients suffering from atopic conditions like allergic rhinitis, asthma and atopic dermatitis. Production of allergen-specific IgE in atopic individuals is driven both by a genetic predisposition to the synthesis of this isotype as well as by environmental factors, including chronic allergen exposure. (more…)
The precise mechanisms underlying the effects of Specific Immunotherapy are not well understood but several studies have shown ...
Our current knowledge for trigger factor and food allergy intolerance is still in it infancy level. We already known that the aller ...
Treatment with omalizumab has been shown to reduce serum free IgE concentrations and to have beneficial effects on allergic airway ...
A paradigm of immune development underlies allergy development and progression in early childhood. Briefly, the immune system o ...
IgE plays an important role in allergic asthma. Reducing IgE in the airway mucosa should reduce airway inflammation. Omalizumab has ...
It will be helpful for you to have some understanding of the terms that are currently being used by practitioners in the field of allergy so that you can understand the medical literature as you search for information on your child’s allergy. Understanding the terms will also pave the way for our discussion of why your child has allergies and what is happening in his or her body when an allergic reaction is occurring. (more…)
Systemic allergic reactions are a relatively common clinical emergency. In their mildest form, they may just manifest as system ...
Food is essential for sustaining human life. Many love to eat and find enjoyment in this activity. But there are literally thou ...
Definitions of anaphylaxis vary considerably, impeding the comparison of different clinical studies. Different definitions of a ...
Having a food intolerance test is becoming increasingly popular nowadays. This is because the symptoms of indigestion, stomach ...
Food allergies are becoming popular topics in the news at the moment. Based on a recent report by the CDC, the number of people ...