A paradigm of immune development underlies allergy development and progression in early childhood. Briefly, the immune system of the fetus is maintained in a tolerogenic state, preventing adverse immune responses and rejection between the mother and fetus. Placental interleukin-10 (IL-10) suppresses the production of immune-potentiating inter-feron gamma (IFN-y) by fetal immune cells. IFN-y downregulates the production of pro-allergic cytokines, such as IL-4 and IL-13. (more…)
In the Tucson CRS study, about 50% of young children experienced a period of recurrent wheezing and/or coughing in the first 6 ...
Treatment with omalizumab has been shown to reduce serum free IgE concentrations and to have beneficial effects on allergic airway ...
The precise mechanisms underlying the effects of Specific Immunotherapy are not well understood but several studies have shown ...
Recently, UK Department of Health has circulated advice aimed at reducing the development of peanut allergy. The advice, base ...
Exposure and allergic sensitization to cockroach was associated with a significantly greater risk of asthma hospitalization and ...
Airway hyper-responsiveness in asthma may involve smooth muscle growth, a manifestation of airway remodelling. The involvement of inflammatory cells in the induction of airway smooth muscle growth was studied in vivo and ex vivo in a brown Norway rat model of asthma. Transfer of CD4 + T lymphocytes from ovalbuminsensitized animals induced an increase in airway smooth muscle mass in naive animals upon repeated ovalbumin challenge. Ex vivo, coculture of antigen-stimulated CD4 + T cells and airway smooth muscle cells led to myocyte proliferation and prolonged T-cell survival. (more…)
Vascular Endothelial Growth Factor (VEGF), originally described as a vascular permeability factor generating tissue oedema, has be ...
Toll-like receptors (TLRs) act as receptors for numerous stimuli of immune cells, including bacterial cell wall constituents (l ...
A role for Leukotriene B4 in the induction of airway hyper-responsiveness was explored through the use of transgenic mice defic ...
IgE plays an important role in allergic asthma. Reducing IgE in the airway mucosa should reduce airway inflammation. Omalizumab has ...
Eosinophil infiltration of the mucosa is a feature of asthmatic airways. Their adhesion to bronchial epithelial cells has been ...
Serodiagnosis of bacterial diseases is of value only in specific circumstances. IgG antibody is long-lived, and its presence, although indicative of previous infection or immunization, gives little or no information on current bacterial infection. IgM antibody is usually produced within days to a few weeks after exposure to antigen, (more…)
Of the several species of Haemophilus that are known, Haemophilus influenzae is the most prevalent pathogen. Several distinct capsu ...
If you have sinusitis, one of the displeasing aspects of sinusitis is dizziness condition that comes with it. Symptoms of sin ...
Immunization is needed for person to be prevented of getting diseases, whereas in bigger scale, it is needed to eradicate the bre ...
Exotoxins are noxious proteins secreted by many bacteria. These toxins are often heat-labile and thus can be heat-inactivated f ...
Immune system is your body’s defense mechanism to protect from infectious organism and other living object invaded your body. T ...
It is common to find anti-food IgG antibodies circulating in blood, even in people who have no signs or history of adverse reactions to foods. In fact, some authorities think that an increase in anti-food IgG in some cases might be indicative of successful resolution of an IgE-mediated allergy. The subject of IgG-mediated food allergy is extremely complicated because of the nature of the antibody and the immunological reactions associated with it. The present knowledge about food allergy-associated IgG may be summarized as follows: (more…)
B cells The main function of B cells is to produce antibodies. Antibodies are complex molecules produced by the immune syste ...
Our current knowledge for trigger factor and food allergy intolerance is still in it infancy level. We already known that the aller ...
Having a food intolerance test is becoming increasingly popular nowadays. This is because the symptoms of indigestion, stomach ...
Antibodies which are also known as immunoglobulin are found in our blood and other bodily fluids. Antibodies are used as a mechan ...
The precise mechanisms underlying the effects of Specific Immunotherapy are not well understood but several studies have shown ...