AP-1 is an inducible transcription factor that binds to promoter or enhancer regions of many cytokine genes, often in close association with the nuclear factor of activated T cells (NF-AT). AP-1 is composed of c-fos and c-jun or c-jun/c-jun homodimers. AP-1 binding has been demonstrated as obligatory for NF-AT-mediated cytokine gene acti- vation in many cases. The signal transduction pathway responsible for AP-1 activation involves jun and p38 kinase-activated protein kinase). (more…)
The overlapping functions of cytokines largely reflect the properties of the cell surface receptors to which they bind. All cyt ...
Perhaps the most exciting recent advance in the cytokine signaling field has been the elucidation of the Jak/Stat pathway. The ...
The Ras-dependent pathway can be triggered by a variety of cytokine receptors, as well as by certain adhesion molecules and by ...
The T-bet (T-box 21) gene (TBX21) encodes a transcription factor, T-box expressed in T cells, which has been implicated in asthma t ...
A previous genome-wide screen for mite-sensitive atopic dermatitis asthma in Japanese families indicated linkage to chromosome 5q33 ...
Drug allergy reactions may be classified, at least theoretically, according to one of four implicated immunologic mechanisms, according to the scheme of Gell and Coombs:
Type I Drug Allergy Reactions
Type I reactions are the result of an IgE antibody reaction, which induces immediate-type hypersensitivity reactions. (more…)
Drug allergy and adverse drug reactions are common among many people. Those side affect of consuming drugs affecting an about 3 ...
Patients (and many doctors) frequently use the term ‘allergy’ when referring to any adverse drug reaction, even one that has no fea ...
This study compared the diagnostic value of intradermal tests and patch tests in 20 patients with non-immediate reactions to pe ...
B cells The main function of B cells is to produce antibodies. Antibodies are complex molecules produced by the immune syste ...
Serum sickness syndrome was first recognized in the pre antibiotic era when heterologous antiserum was used as passive immuniza ...