Common Variable Immunodeficiency (CVID) is the most frequent primary immunodeficiency in man that requires medical intervention. Most cases are sporadic, but about 10% are familial, with a predominance of autosomal dominant over autosomal recessive inheritance. It has recently been shown that homozygous loss of the inducible costimulator (ICOS) on activated T cells may result in an adult form of CVID with autosomal recessive inheritance. ICOS belongs to the family of costimulatory T-cell molecules such as CD28 and CTLA-4. (more…)
The molecular basis of Common Variable Immunodeficiency (CVID) is unknown and the diagnosis requires the exclusion of other disease ...
Primary immunodeficiencies occur with a frequency approaching that of cystic fibrosis (1:2500 live births). However, because they a ...
This study sought to determine the influence of passive exposure to tobacco smoke during childhood on the results of genetic linkag ...
The T-bet (T-box 21) gene (TBX21) encodes a transcription factor, T-box expressed in T cells, which has been implicated in asthma t ...
A previous genome-wide screen for mite-sensitive atopic dermatitis asthma in Japanese families indicated linkage to chromosome 5q33 ...
Patients (and many doctors) frequently use the term ‘allergy’ when referring to any adverse drug reaction, even one that has no features of an IgE-mediated allergy response. However, IgE-mediated allergy explains only about 10% of all adverse reactions to antigen antibody reactions from antibiotics. Patients who have experienced unexplained symptoms during treatment with two or more antibiotics are often said to have ‘multiple antibiotic allergy’; using this definition, the description can be applied to one patient in every 22. (more…)
This study compared the diagnostic value of intradermal tests and patch tests in 20 patients with non-immediate reactions to pe ...
Suspected drug allergy is not easy to investigate. In the UK, few centers have the necessary facilities and expertise, the evid ...
Drug allergy reactions may be classified, at least theoretically, according to one of four implicated immunologic mechanisms, a ...
Allergy skin testing is probably the most susceptible and practical way to monitor for existing allergy sensitivity. Biological ...
One of the popular allergy testing besides food allergy testing is skin allergy testing. Allergy patch test is the most commo ...
Specific immunotherapy has been widely used to treat allergic rhinitis symptoms. As with any other form of specific immunotherapy, careful patient selection is crucial. The diagnosis of allergic rhinitis needs to be secure, especially in those with perennial symptoms, and should be based on a careful clinical history supported by documentation of IgE-mediated sensitivity by skin prick test or blood tests. (more…)
About twenty percent of patients who have common allergic rhinitis are also having perennial allergic rhinitis symptoms. This f ...
Allergen-specific immunotherapy aims to correct the underlying immune imbalance associated with specific immunotherapy allergic rhi ...
Allergic rhinitis is a very common problem associated with poor quality of life, reductions in social and work activities and p ...
It is now almost a century since the pioneering work of Noon and Freeman was used to successfully treat hay fever symptoms usin ...
Allergic rhinitis is a high-prevalence disease. This high prevalence translates into a high cost to society in terms of overall ...