Multiple Antibiotic Allergy Syndrome| Penicilin Allergies

Patients (and many doctors) frequently use the term ‘allergy’ when referring to any adverse drug reaction, even one that has no features of an IgE-mediated allergy response. However, IgE-mediated allergy explains only about 10% of all adverse reactions to antigen antibody reactions from antibiotics. Patients who have experienced unexplained symptoms during treatment with two or more antibiotics are often said to have ‘multiple antibiotic allergy’; using this definition, the description can be applied to one patient in every 22. (more…)

Allergic Rhinitis and Urticaria Treatment with H1 Antihistamines

First-generation, relatively sedating oral H1 antihistamines such as diphenhydramine and chlorpheniramine have no role in the out-of-hospital management of children with allergic rhinitis diseases. Most of the older H1 antihistamines, although available in palatable liquid formulations, have not been optimally studied in infants or allergy in children. (more…)