The airway circulation has many potential roles in asthma. The vasculature has a major influence on upper airway patency in nasal infection and atopic responses. Given its responsiveness to provocative stimuli in asthma and vasoconstrictive and antiproliferative response to corticosteroids, the bronchial circulation is likely to be a future target for novel asthma therapies. (more…)
Local micro environmental factors are crucial in determining both susceptibility to vascular remodeling and the extent of angio ...
Vascular Endothelial Growth Factor (VEGF), originally described as a vascular permeability factor generating tissue oedema, has be ...
Eosinophil infiltration of the mucosa is a feature of asthmatic airways. Their adhesion to bronchial epithelial cells has been ...
Acute inflammatory response constitute the first line of defense against infection pathogenesis and how immune system works as ...
IgE plays an important role in allergic asthma. Reducing IgE in the airway mucosa should reduce airway inflammation. Omalizumab has ...