The prevalence of aspirin-sensitive asthma is uncertain although it may exist in up to 20% of all asthmatics patients. The characteristic features include profound bronchoconstriction asthma following aspirin ingestion, rhinosinusitis, nasal polyps, and abdominal cramps. Aspirin and nonsteroidal antiinflammatory drugs selectively inhibit COX-1, which in turn shunts arachidonic acid down the 5-lipoxygenase activating protein pathway, causing overproduction of cysteinyl leukotrienes. As a consequence, elevated levels of cysteinyl leukotrienes can be found in bronchial asthma and nasal aspirates, and in urine following aspirin challenge. (more…)
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) as one of the popular pain reliever is among regular aspirin, ibuprofen (Advil a ...
Leukotrienes can be found in the airway and urine following both spontaneous exacerbations of asthma and acute exposure to bron ...
Despite optimum drug delivery and good compliance with inhaled corticosteroids, many patients experience symptoms and exacerbat ...
The cross-sensitivity between aspirin and Non Steroidal Anti Inflammatory Drugs in patients who manifest pseudo-allergic reacti ...
Current internationally recognized guidelines indicate that symptomatic asthmatics using a low to medium inhaled corticosteroid ...
This study sought to determine the influence of passive exposure to tobacco smoke during childhood on the results of genetic linkage analyses for asthma. A genome wide linkage screen for asthma and bronchial hyper responsiveness was performed in 200 families (containing 1183 individuals) from The Netherlands. A set of 266 polymorphic autosomal markers was used. Analyses were performed separately for the entire population and for the smoking exposed and non exposed families separately. (more…)
CD14 is part of the receptor complex for endotoxin, which is a component of tobacco smoke. The CD14 gene is located on chromoso ...
The effects of exposure to environmental tobacco smoke (ETS) on children have been extensively studied and numerous surveys hav ...
Allergic rhinitis and asthma are common comorbidities. Like asthma, the presence of a genetic component in allergic rhinitis ha ...
A previous genome-wide screen for mite-sensitive atopic dermatitis asthma in Japanese families indicated linkage to chromosome 5q33 ...
Avoidance of any one of the individual risk factors associated with childhood asthma has not been successful in preventing its deve ...
Exercise-induced asthma is a feeling of shortness of breath, with the presence of cough, wheezing, and chest tightness after physical exercise.
Normally the bronchial tree and bronchial vessels responds to exercise with increasing radius of the interior of the bronchi (bronchodilation), (more…)
A history of cough, dyspnea, wheezing, chest tightness or performance problems during exercise suggests the person may have Exercis ...
We live and train at altitude. I say I'm too tall to have shortness of breath, but at times I do. After a couple of years here ...
Up to 85% of asthmatics patients have symptoms of wheezing during or after exercise. Moreover, many patients diagnosed with all ...
It is widely knowt that pollen, pollution, smoke can trigger an asthma attack. But one interesting thing is exercise can also trigg ...
This article focuses on symptoms of exercise induced asthma. Exercise can be a trigger factor when asthma is not well control ...
Local micro environmental factors are crucial in determining both susceptibility to vascular remodeling and the extent of angiogenesis. Major exogenous triggers of airway inflammation in asthma include viruses and inhaled aeroallergens, both of which are known to be associated with the production of angiogenic factors . These stimuli elicit reciprocal immune responses, through elaboration of Th1 and Th2 cytokines. (more…)
Vascular Endothelial Growth Factor (VEGF), originally described as a vascular permeability factor generating tissue oedema, has be ...
The airway circulation has many potential roles in asthma. The vasculature has a major influence on upper airway patency in nasal i ...
Exacerbations of asthma are frequently associated with rhinoviral infection. Rhinoviruses infect respiratory epithelial cells, ...
While our primary concern is the impact that the innate immune system has on allergic disease, it is essential to recognize that al ...
Eosinophil infiltration of the mucosa is a feature of asthmatic airways. Their adhesion to bronchial epithelial cells has been ...