Natural history studies with the following design features provide a firm epidemiologic foundation for risk factor assessments and etiologic hypotheses:
(1) long-term cohort studies of a prospective design minimize biases resulting from poor parental recall;
(2) multiple evaluations over time provide important checkpoints during the dynamic period of childhood growth and development; and
(3) the inclusion of objective disease measurements strengthens these studies by validating subjective disease assessments (i.e. questionnaire data). (more…)
Atopic Dermatitis is considered to be one of the first manifestations in the atopic march. The aim of this study was to investi ...
In the Tucson CRS study, about 50% of young children experienced a period of recurrent wheezing and/or coughing in the first 6 ...
There is much controversy as to the role of allergen exposure for the development of atopic sensitization towards this allergen. Wh ...
Sensitization to pets remains a risk factor for asthma and rhinitis, and can occur in people who have never lived with a pet. S ...
Avoidance of any one of the individual risk factors associated with childhood asthma has not been successful in preventing its deve ...
It is clear from the results of large epidemiologic studies that while atopy is a major risk factor for asthma, it is usually not sufficient by itself to drive the disease process to chronicity, as less than 25% of atopics develop persistent asthma. The situation in childhood is further complicated by an additional series of development factors, related to postnatal maturation of respiratory function. (more…)
In the Tucson CRS study, about 50% of young children experienced a period of recurrent wheezing and/or coughing in the first 6 ...
Natural history studies with the following design features provide a firm epidemiologic foundation for risk factor assessments and ...
Atopic Dermatitis is considered to be one of the first manifestations in the atopic march. The aim of this study was to investi ...
Asthma is a complex syndrome rather than a single disease entity. Different phenotypes with varying prognosis and determinants have ...
More severe asthma can persist from childhood into adulthood without remission. Another important tendency in the natural histo ...