Primary Immunodeficiencies: Antibody Deficiency and Immunoglobulin Replacement Therapy

Primary immunodeficiencies occur with a frequency approaching that of cystic fibrosis (1:2500 live births). However, because they are perceived to be very rare and usually present with common infections, they are under-diagnosed. Often the diagnosis is not considered until substantial end-organ damage has occurred, by which time definitive treatment is only partially successful in preventing further infections. (more…)

Haemophilus Influenzae Type B

Of the several species of Haemophilus that are known, Haemophilus influenzae is the most prevalent pathogen. Several distinct capsular serotypes have been defined, but type b H influenzae is responsible for most clinical disease. H influenzae is a respiratory pathogen that colonizes the oropharynx and causes bronchitis, pneumonia, or disseminated infection when local or systemic host defense factors are compromised. (more…)

Antibodies and the Immune Response - Human Immune System

antibodies immune response

B cells

The main function of B cells is to produce antibodies. Antibodies are complex molecules produced by the immune system in response to antigens. As mentioned previously, antigens are foreign proteins or glycoproteins (a sugar linked to a protein) that trigger the immune response. Every living cell produces several different proteins, each unique to its own cell type and species. The antibody produced against the antigen is entirely specific to that antigen. (more…)

Methods for the Assessment of Allergen Vaccine Quality

Allergen Vaccine Quality
The quality of an allergen vaccine is a measure of the complexity of the composition, including the concentration of the various constituents. That is, the presence or absence of individual constituents determines the quality. Only selected constituents (i.e., the major allergens or other marker proteins) can be quantified independently. The complexity of the composition of allergen vaccines can be assessed by several techniques. These are standard separation techniques in biochemistry and traditional immunochemistry. (more…)

Antibodies and the Immune Response

Antibodies which are also known as immunoglobulin are found in our blood and other bodily fluids. Antibodies are used as a mechanism by natural immune system to identify, counteract, and neutralize foreign objects which are entered our body. B Cells is the first cell reacted when foreign objects entered our body and triggered the first alarming mode of immune system. It then try to recognize it and subsequently will proceed in the antibody production. There are five different types of antibody produced: IgA, IgG,IgM, IgE and IgD. Bellow we will discuss B Cells in antibody production process and three of the most prominent antibodies: IgA, IgM, and IgG.

B Cells in Antibody Production Process

B cells main function is in the process of antibody production. As you probably know, antibodies are complex structured molecules as result of body immune systems in response to antigens which are entered our body. Antigens are foreign subtracted objects which are mainly (more…)

How Immune System Works - Antigen Antibody Reaction

immune system body protection
Immune system is your body’s defense mechanism to protect from infectious organism and other living object invaded your body. The body reacts through several cellular immune response, and immune system attacks those foreign objects which may cause disease. Immune system consisted of network cells, skins, tissue and organs which work closely to protect body. How immune system works?

Immune system is so important for us to survive since we are surrounded by virus, fungus, parasite and bacteria which always trying to break into our body. (more…)