The potency of an allergen vaccine is the total allergen activity (that is, the sum of the contribution to allergenic activity from any individual IgE molecule specific for any t-cell epitopes on any molecule in the allergen vaccine). It follows that potency measures always will depend on the serum pool or patient panel selected as well as the methodology used. Methods used for the assessment of allergen vaccine potency may be divided into in vitro or in vivo techniques. (more…)
The quality of an allergen vaccine is a measure of the complexity of the composition, including the concentration of the variou ...
A subcommittee under the International Union of Immunological Societies (IUIS) for the establishment of international standards (IS ...
Allergen vaccines are complex mixtures of antigenic components produced by the extraction of naturally occurring source materia ...
Having determined an adequate potency and complexity in composition, an allergen vaccine may still be deficient in the content of m ...
Being an immunological disease, the characteristics of allergy are those of specificity and memory. Regardless of whether the c ...
Nerve fibers containing a variety of neuropeptides, including substance P and CGRP, have been demonstrated in human skin. Intradermal injection of substance P results in an immediate wheal-and-flare reaction , whereas the main effect of CGRP is a long-lasting (4–6 hours) intense erythema. Additionally, CGRP potentiates edema formation evoked by mediators such as substance P. (more…)
After nasal allergen challenge, substance P and CGRP are released into nasal secretions of atopic patients . In allergic rhinit ...
The immunologic mechanisms of sublingual immunotherapy are less established. In Cochrane analysis, the authors concluded that t ...
The potency of an allergen vaccine is the total allergen activity (that is, the sum of the contribution to allergenic activity from ...
Allergy skin testing is probably the most susceptible and practical way to monitor for existing allergy sensitivity. Biological ...
The sensory neuropeptides substance P and neurokinin A (NKA) are members of the tachykinin family, present within pulmonary sensory ...