The induction of immune tolerance and specific immune suppression are essential processes in the control of immune responses. Regulatory T cells (Treg) play a central role in immune control in the periphery. Two broad categories of Treg have been described: naturally occurring Treg that are present in all individuals and antigen-induced Treg that secrete inhibitory cytokines such as interleukin (IL)-10 and/or transforming growth factor (TGF)-ß. (more…)
Regulatory T cells Treg (picture above) is the existence of suppressor cells, which limit ongoing immune responses and prevent ...
An emerging concept is that pro-inflammatory signals lead to loss of Regulatory T Cells (Treg) function. Pasare and Medzhitov ( ...
Treg cells or regulatory T cells constitute a large population of cellular infiltrate in atopic/allergic inflammation and a dys ...
The intracellular forkhead winged transcription factor Foxp3 (forkhead box P3) appears to be specifically expressed by naturall ...
Allergen-specific immunotherapy is highly effective in the treatment of IgE-mediated allergy diseases such as rhinitis, conjunc ...
Treatment of allergic diseases in childhood presents unique challenges, as both the beneficial effects and the detrimental effects of intervention(s) may last for decades and even for a lifetime. Most allergic diseases are managed in a community setting by primary care physicians, rather than in a hospital setting by allergy specialists. Here, we describe outpatient treatment, which is focused on prevention and relief of morbidity from allergic diseases and on the identification of children at high risk (more…)
Allergen-specific immunotherapy aims to correct the underlying immune imbalance associated with specific immunotherapy allergic rhi ...
Expert GA ² LEN, the Global Network European Allergy and Asthma European Academy of Allergy and Clinical Immunology, EAACI, warn th ...
Specific immunotherapy has been widely used to treat allergic rhinitis symptoms. As with any other form of specific immunotherapy, ...
Allergic rhinitis is a very common problem associated with poor quality of life, reductions in social and work activities and p ...
Many kids’ deaths in the United States over the years happened both in schools and children camps because of lack of access to ...
If someone has allergies, and it is particularly food allergies, does it change his or her quality of life?
The effects of allergic diseases are different compare to many various other diseases. Only a small number of people having allergic disease are ended deadly. Rather, it affects the quality of life for longer period of time. (more…)
It will be helpful for you to have some understanding of the terms that are currently being used by practitioners in the field ...
No cure is available for food allergy and food-allergic patients and their families are therefore burdened with the need to con ...
Treatment of allergic diseases in childhood presents unique challenges, as both the beneficial effects and the detrimenta ...
Families frequently do not use their self-injectable adrenaline device, even when their kids is experiencing a potentially life ...
Systemic allergic reactions are a relatively common clinical emergency. In their mildest form, they may just manifest as system ...
Activation of the innate immune system is an integral part of the pathology of allergic diseases such as asthma, with a dual role that has different emphases in disease initiation and disease perpetuation. Sadly underappreciated in the past, the resurgence in interest in innate immunobiology has been spearheaded by the identification of the TLR system and its huge contribution to health and disease. (more…)
Innate immunity depends on both resident and recruited leukocytes. The macrophage without doubt plays an import- ant role in the de ...
Contact of pathogens with the innate immune system will most frequently occur at epithelia, and the biology of the airway epitheliu ...
While our primary concern is the impact that the innate immune system has on allergic disease, it is essential to recognize that al ...
Innate immune responses are seen in a very broad range of tissues. Indeed, the Toll-like receptors (TLRs, one of the most important ...
Toll-like receptors (TLRs) act as receptors for numerous stimuli of immune cells, including bacterial cell wall constituents (l ...
The precise mechanisms underlying the effects of Specific Immunotherapy are not well understood but several studies have shown that Specific Immunotherapy T inhibits both early and late immune responses to allergen exposure.
Recently, there have been many studies aimed at elucidating the mechanisms by which allergen-specific immunotherapy works. (more…)
The immunologic mechanisms of sublingual immunotherapy are less established. In Cochrane analysis, the authors concluded that t ...
Histamine is a low-molecular-weight monoamine that binds to four different G-protein-coupled receptors, and has recently been d ...
Allergen-specific immunotherapy aims to correct the underlying immune imbalance associated with specific immunotherapy allergic rhi ...
Allergen-specific immunotherapy is highly effective in the treatment of IgE-mediated allergy diseases such as rhinitis, conjunc ...
The specific treatment of allergy has previously relied upon allergen avoidance and sublingual immunotherapy. These approaches have ...
The allergen extracts used for diagnosis and treatment of allergic diseases. In the process of fabricating of allergen extracts, it is important to apply the standards to address the variability nature of the materials. Other important consideration is to look for the way to reproduce and control the optimum safety and efficaciousness when used in clinics. (more…)
The production of allergen vaccines imposes a number of constraints on both the selection of source materials and the physicoch ...
Allergen vaccines are complex mixtures of antigenic components produced by the extraction of naturally occurring source materia ...
Being an immunological disease, the characteristics of allergy are those of specificity and memory. Regardless of whether the c ...
The oral allergy syndrome is difficult to detect. Common allergy tests to examine allergy are using extracts only in skin scrat ...
The diagnostic approach to allergic food reactions comprises three steps. The first step includes the medical allergy history, ...