Allergic rhinitis and asthma are common comorbidities. Like asthma, the presence of a genetic component in allergic rhinitis has been well established. To identify genetic linkage regions unique to allergic rhinitis, as well as those shared by allergic rhinitis and asthma, a genome screen study was conducted. A total of 295 families in the French Epidemiological Study on the Genetics and Environment of Asthma (EGEA) containing 1317 subjects were genotyped for 396 microsatellite markers. The families included had two siblings with DNA available and at least one asthmatic subject. Three definitions of allergic rhinitis were used, two binary and one categorical. To investigate linkages specific to allergic rhinitis (without asthma), linkage analyses were also conducted in 185 families with at most one asthmatic sib. (more…)
This study sought to determine the influence of passive exposure to tobacco smoke during childhood on the results of genetic linkag ...
This study examined the genetic basis of sensitization to house dust mite allergy allergens. A genome scan was conducted usin ...
About twenty percent of patients who have common allergic rhinitis are also having perennial allergic rhinitis symptoms. This f ...
A previous genome-wide screen for mite-sensitive atopic dermatitis asthma in Japanese families indicated linkage to chromosome 5q33 ...
Asthmatic children who also have Allergic Rhinitis seem to have higher morbidity and to use more healthcare resources. This was fur ...
Anti-IgE therapy could be particularly beneficial for patients with concomitant asthma and rhinitis as it targets a common factor in the two diseases. Omalizumab is significantly more efficacious than placebo in preventing asthma exacerbations and in improving disease-related quality of life scores when added to standard asthma and rhinitis therapies. (more…)
Patients with severe persistent asthma who are inadequately controlled despite Global Initiative for Asthma (GINA) 2002 step 4 ther ...
Treatment with omalizumab has been shown to reduce serum free IgE concentrations and to have beneficial effects on allergic airway ...
IgE plays an important role in allergic asthma. Reducing IgE in the airway mucosa should reduce airway inflammation. Omalizumab has ...
Allergic rhinitis is a very common problem associated with poor quality of life, reductions in social and work activities and p ...
This study evaluated budesonide formoterol efficacy and safety of a novel asthma management strategy for both maintenance and s ...
Tumour Necrosis Factor is a pro-inflammatory cytokine implicated in the pathogenesis of asthmatic airway inflammation, hyper-reactivity and remodelling. The primary aim of the trial was to assess whether TNF antagonism, using a soluble Tumour Necrosis Factor receptor (TNFR:Fc etanercept, Enbrel ® ), can attenuate eosinophilic airway inflammation in patients with mild to moderate allergic asthma. (more…)
Tumour necrosis factor alpha (TNF-a) is a major therapeutic target in a range of chronic inflammatory disorders involving neutr ...
Marimastat is a synthetic broad-spectrum matrix metalloproteinase (MMP) inhibitor. This study assessed the anti-inflammatory effect ...
Roflumilast is an oral, once-daily inhibitor of phosphodiesterase type 4 (PDE4) that prevents the breakdown of cyclic adenosine ...
IgE plays an important role in allergic asthma. Reducing IgE in the airway mucosa should reduce airway inflammation. Omalizumab has ...
Vascular Endothelial Growth Factor (VEGF), originally described as a vascular permeability factor generating tissue oedema, has be ...
IgE plays an important role in allergic asthma. Reducing IgE in the airway mucosa should reduce airway inflammation. Omalizumab has significant anti-inflammatory effect and reduces serum and airway IgE, but IgE or eosinophils may not be causally linked to airway bronchial hyperresponsiveness to methacholine in mild to moderate asthma. (more…)
Treatment with omalizumab has been shown to reduce serum free IgE concentrations and to have beneficial effects on allergic airway ...
Anti-IgE therapy could be particularly beneficial for patients with concomitant asthma and rhinitis as it targets a common fact ...
Patients with severe persistent asthma who are inadequately controlled despite Global Initiative for Asthma (GINA) 2002 step 4 ther ...
Tumour Necrosis Factor is a pro-inflammatory cytokine implicated in the pathogenesis of asthmatic airway inflammation, hyper-react ...
Tumour necrosis factor alpha (TNF-a) is a major therapeutic target in a range of chronic inflammatory disorders involving neutr ...
Classification of bronchial asthma can be based on age, etiology, associated characteristics, or severity. Classifications based on severity have been primarily designed as an approach to asthma treatment. Thus, management of mild intermittent disease may require only bronchodilator treatment, but frequent attacks with or without persistent mild symptoms require a comprehensive approach to controlling inflammation as well as bronchodilator treatment. Severe asthma can become a major clinical problem that requires specialist care and many different approaches to asthma attack treatment. (more…)
Allergic rhinitis is a high-prevalence disease. This high prevalence translates into a high cost to society in terms of overall ...
The two strongest risk factors for asthma in childhood are a family history and immediate hypersensitivity to common allergens. ...
If you have sinusitis, one of the displeasing aspects of sinusitis is dizziness condition that comes with it. Symptoms of sin ...
Asthma is a continuing problem for healthcare, particularly in the industrialized world. Some 150 million people are estimated ...
Treatment of allergic diseases in childhood presents unique challenges, as both the beneficial effects and the detrimenta ...
It is very common in asthmatic children where overprotective parents prevent a normal level of exercise to their kids. However, a controlled sport appropriate to the course of their disease is very healthy.
Asthma is an inflammatory disease of the airways characterized by variable bronchial obstruction and reversible, either spontaneously or with treatment, (more…)
Asthma treatment has one main goal to maintain a normal and healthy lifestyle, including exercise and other physical activities. Pe ...
Up to 85% of asthmatics patients have symptoms of wheezing during or after exercise. Moreover, many patients diagnosed with all ...
It is widely knowt that pollen, pollution, smoke can trigger an asthma attack. But one interesting thing is exercise can also trigg ...
Most attacks of asthma, though frightening and uncomfortable, are usually mild and subside within a few minutes with simple treatme ...
This article focuses on symptoms of exercise induced asthma. Exercise can be a trigger factor when asthma is not well control ...
The two strongest risk factors for asthma in childhood are a family history and immediate hypersensitivity to common allergens. This immune response includes both IgE antibodies and helper T cells type 2 (Th2), both of which are thought to contribute to the inflammation in the respiratory tract. Children with asthma who mount an immune response to inhalant allergens have an increased risk of developing asthma because of this combination of genetics and exposure. However, it is sensitization to indoor allergens (e.g. dust mites, cats, dogs, and cockroaches) that is strongly associated with asthma. (more…)
Exposure and allergic sensitization to cockroach was associated with a significantly greater risk of asthma hospitalization and ...
There is much controversy as to the role of allergen exposure for the development of atopic sensitization towards this allergen. Wh ...
Classification of bronchial asthma can be based on age, etiology, associated characteristics, or severity. Classifications base ...
Sensitization to pets remains a risk factor for asthma and rhinitis, and can occur in people who have never lived with a pet. S ...
This population-based cross-sectional study, funded by a UK government agency, aimed to establish the rate of sensitization to food ...
A preliminary study conducted in New Zealand shows that a natural chemical compound blackcurrants can help breathe allergic asthma sufferers. It was known that fruit consumption may reduce symptoms of allergic asthma, but this study is the first to demonstrate how this phenomenon occurs. (more…)
Allergens are the trigger for human body allergic reaction. It is one of human immunological process to react for invader subst ...
Allergies can be defined as inappropriate immune system reactions to a foreign substance entering body. Allergies are kind of disea ...
Discovering natural treatment for allergies is still the main goal for a growing number of people suffering from allergies. At ...
Sinusitis is one inconvenience disease condition that many people had. Many drugs and antibiotics that are prescribed by your docto ...
Some of the immediate sequelae of injury are uncomfortably familiar: Soon after an injury occurs, the affected site and its sur ...
Allergy and asthma are surrounding many of us. People suffer from various allergy and asthma that are caused by food, dust, and sometimes flowers. This is a situation where our immune system reacts to some natural substances and causes discomfort. Asthma on the other hand happens when the bronchial muscles get tensed making the windpipe congested and resulting in breathing problems. (more…)
As a person who suffered form allergies and have a profession as family physician, I have much sympathy for those struggling with i ...
Asthma is a big problem worldwide today. Many people who suffer from asthma do not even realize they have it until it gets out ...
If the onset of summer brings with it itchy eyes, a runny nose and sneezing then it is very likely that you suffer from hayfeve ...
Do you find yourself feeling miserable, coughing, or sneezing at about the same time each and every year? If you do, it is impo ...
Allergies can be extremely frustrating and attack at the worst possible times. While doctors may prescribe medication to those ...
Over the last few years, medical science has discovered many new drugs to prevent attacks, as well as to control attacks when they occur. The first step that a physician takes is to assess the patient’s asthma. This can be done by tests that measure the actual amount of air in the lungs. The usual medicine offered is termed a: Bronchodilator - because it dilates or widens the narrowed air passages by relaxing the muscles in their walls. Medicines must be carefully selected for individual patients. (more…)
Most attacks of asthma, though frightening and uncomfortable, are usually mild and subside within a few minutes with simple treatme ...
Up to 85% of asthmatics patients have symptoms of wheezing during or after exercise. Moreover, many patients diagnosed with all ...
Asthma is a disease marked by wheezing, coughing, and difficulty in breathing. It is a form of allergy, a physical reaction of some ...
It is important that you understand what asthma medicine to flare up so that you can treat your asthma. Knowing how to control ...
Asthma treatment has one main goal to maintain a normal and healthy lifestyle, including exercise and other physical activities. Pe ...