It is now almost a century since the pioneering work of Noon and Freeman was used to successfully treat hay fever symptoms using a low-dose incremental schedule of pollen injections. Noon based his doses of pollen extract on a pollen weight unit that remained in use for over 70 years; (more…)
Allergen-specific immunotherapy aims to correct the underlying immune imbalance associated with specific immunotherapy allergic rhi ...
The safety of immunotherapy has been a constraint on this form of treatment for allergic disease. Although retrospective survey ...
Anaphylactic reactions to Hymenoptera venom are relatively uncommon but can be life-threatening: venom immunotherapy is the treatme ...
Specific immunotherapy has been widely used to treat allergic rhinitis symptoms. As with any other form of specific immunotherapy, ...
Allergic rhinitis is a very common problem associated with poor quality of life, reductions in social and work activities and p ...
The diagnostic approach to allergic food reactions comprises three steps. The first step includes the medical allergy history, physical examination, and family allergy background. On the basis of symptoms and timing of the reaction, the physician attempts to identify the suspected food and to determine whether the reaction is likely to involve an immunologic mechanism. This first step is absolutely necessary to decide on the subsequent diagnostic tests to be performed. The second step includes allergy skin tests and in vitro assays, which can confirm a sensitization to the food. (more…)
One of the popular allergy testing besides food allergy testing is skin allergy testing. Allergy patch test is the most commo ...
Over the last 5 years some studies have suggested that the atopy patch test (APT) may be a useful test in atopic dermatitis childre ...
Allergy skin testing is probably the most susceptible and practical way to monitor for existing allergy sensitivity. Biological ...
Diagnosis of food hypersensitivity is a clinical challenge and the only current definitive test is the Double Blind Placebo-Control ...
This population-based cross-sectional study, funded by a UK government agency, aimed to establish the rate of sensitization to food ...
Allergen vaccines are complex mixtures of antigenic components produced by the extraction of naturally occurring source materials, which are known to vary considerably in composition. Without intervention, this variation will be reflected in the final products.
The purpose of standardization is to minimize both qualitative and quantitative variations in composition so that a higher level of safety, efficacy, accuracy, and simplicity in allergy diagnosis and allergy vaccination may be obtained. Standardization of allergen vaccines can never be absolute, but it can be improved progressively as new methodologies and technologies are developed and the understanding of the properties of the allergens and the immune responses of allergic patients is increased. (more…)
The quality of an allergen vaccine is a measure of the complexity of the composition, including the concentration of the variou ...
Being an immunological disease, the characteristics of allergy are those of specificity and memory. Regardless of whether the c ...
The potency of an allergen vaccine is the total allergen activity (that is, the sum of the contribution to allergenic activity from ...
The production of allergen vaccines imposes a number of constraints on both the selection of source materials and the physicoch ...
Having determined an adequate potency and complexity in composition, an allergen vaccine may still be deficient in the content of m ...