The prevalence of aspirin-sensitive asthma is uncertain although it may exist in up to 20% of all asthmatics patients. The characteristic features include profound bronchoconstriction asthma following aspirin ingestion, rhinosinusitis, nasal polyps, and abdominal cramps. Aspirin and nonsteroidal antiinflammatory drugs selectively inhibit COX-1, which in turn shunts arachidonic acid down the 5-lipoxygenase activating protein pathway, causing overproduction of cysteinyl leukotrienes. As a consequence, elevated levels of cysteinyl leukotrienes can be found in bronchial asthma and nasal aspirates, and in urine following aspirin challenge. (more…)
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) as one of the popular pain reliever is among regular aspirin, ibuprofen (Advil a ...
Leukotrienes can be found in the airway and urine following both spontaneous exacerbations of asthma and acute exposure to bron ...
Despite optimum drug delivery and good compliance with inhaled corticosteroids, many patients experience symptoms and exacerbat ...
The cross-sensitivity between aspirin and Non Steroidal Anti Inflammatory Drugs in patients who manifest pseudo-allergic reacti ...
Current internationally recognized guidelines indicate that symptomatic asthmatics using a low to medium inhaled corticosteroid ...
This study was similar to the study of Harrison and colleagues, which looked at doubling the dose of inhaled corticosteroid during an asthma exacerbation. This study investigated whether doubling the dose of budesonide inhalation in patients on regular inhaled budesonide would be beneficial during an asthma exacerbation. (more…)
The management of asthma in the community involves patient education to avoid the triggers, doubling the dose of inhaled steroi ...
The guidelines for asthma management recommend the use of regular inhaled corticosteroid in patients with mild persistent asthma, b ...
Asthma control is improved by combining inhaled corticosteroids with long acting beta-agonists but patients still require relie ...
This study evaluated budesonide formoterol efficacy and safety of a novel asthma management strategy for both maintenance and s ...
The role of oral and inhaled corticosteroids in the management of acute asthma is well known. This study compared the effects of in ...
Tumour Necrosis Factor is a pro-inflammatory cytokine implicated in the pathogenesis of asthmatic airway inflammation, hyper-reactivity and remodelling. The primary aim of the trial was to assess whether TNF antagonism, using a soluble Tumour Necrosis Factor receptor (TNFR:Fc etanercept, Enbrel ® ), can attenuate eosinophilic airway inflammation in patients with mild to moderate allergic asthma. (more…)
Tumour necrosis factor alpha (TNF-a) is a major therapeutic target in a range of chronic inflammatory disorders involving neutr ...
Marimastat is a synthetic broad-spectrum matrix metalloproteinase (MMP) inhibitor. This study assessed the anti-inflammatory effect ...
Roflumilast is an oral, once-daily inhibitor of phosphodiesterase type 4 (PDE4) that prevents the breakdown of cyclic adenosine ...
IgE plays an important role in allergic asthma. Reducing IgE in the airway mucosa should reduce airway inflammation. Omalizumab has ...
Vascular Endothelial Growth Factor (VEGF), originally described as a vascular permeability factor generating tissue oedema, has be ...
Allergen avoidance has been recommended in the management of allergic asthma children. Very few studies have assessed the effect of pet removal on pet allergic asthma. The authors examined the effect of pet removal from homes on pulmonary function testing, bronchial
hyper-responsiveness and medication use. This was a prospective, controlled but non-randomized and open study. Subjects included 20 symptomatic patients with newly diagnosed pet allergic asthma who were keeping domestic animals, including hamsters, cats, dogs and ferrets, and were sensitized to these animals. (more…)
Sensitization to pets remains a risk factor for asthma and rhinitis, and can occur in people who have never lived with a pet. S ...
This study was similar to the study of Harrison and colleagues, which looked at doubling the dose of inhaled corticosteroid dur ...
The T-bet (T-box 21) gene (TBX21) encodes a transcription factor, T-box expressed in T cells, which has been implicated in asthma t ...
Do you suspect that you have a pet allergy? If you do, you may be looking for ways to seek relief or you may be looking for tips o ...
Pet dander allergy is possibly the most common form of allergy to pets, although some people are also allergic to pets urine or ...
The guidelines for asthma management recommend the use of regular inhaled corticosteroid in patients with mild persistent asthma, but in clinical practice it has been observed that patients often do not feel the need to use their inhaled corticosteroid regularly, which may lead to poor compliance. One possible reason is that because there are no symptoms the patients are not reminded to use their medications. Hence, the use of intermittent inhaled corticosteroid during worsening of asthma may be an option that could be considered in these subgroups of asthmatics. (more…)
This study was similar to the study of Harrison and colleagues, which looked at doubling the dose of inhaled corticosteroid dur ...
Patients with severe persistent asthma who are inadequately controlled despite Global Initiative for Asthma (GINA) 2002 step 4 ther ...
Despite optimum drug delivery and good compliance with inhaled corticosteroids, many patients experience symptoms and exacerbat ...
The management of asthma in the community involves patient education to avoid the triggers, doubling the dose of inhaled steroi ...
Maintenance of asthma control by once-daily inhaled ciclesonide nasal spray in adults with persistent asthma. Ciclesonide is an ...
The role of oral and inhaled corticosteroids in the management of acute asthma is well known. This study compared the effects of inhaled fluticasone propionate with those of intravenous hydrocortisone in patients with acute severe asthma.
One hundred and six patients with acute severe asthma were assigned in a double-blind, randomized manner to receive fluticasone propionate by means of a metered-dose inhaler into a spacer device in a dose of two puffs at 10-min intervals (3000 µg fluticasone propionate/h), or intravenous hydrocortisone. (more…)
This study was similar to the study of Harrison and colleagues, which looked at doubling the dose of inhaled corticosteroid dur ...
For most patients, asthma is not controlled as defined by guidelines; whether this is achievable has not been prospectively stu ...
The management of asthma in the community involves patient education to avoid the triggers, doubling the dose of inhaled steroi ...
Treating allergic rhinitis may have a downstream effect on concomitant asthma and this may be due to attenuation of the underlying ...
This study evaluated budesonide formoterol efficacy and safety of a novel asthma management strategy for both maintenance and s ...
The symptoms of asthma occur together with variations in the diameter of medium- size airways such that it is increasingly difficult to exhale. Narrowing of the airways can occur because of smooth muscle contraction, edema or swelling of the wall, or increased mucus in the airways. However, it is increasingly clear that the pathologic event underlying most cases of asthma is acute inflammation of the airway walls. (more…)
There are other signs and symptoms of asthma. People with asthma can be feeling irritable because of asthma discomfort. Some si ...
IgE plays an important role in allergic asthma. Reducing IgE in the airway mucosa should reduce airway inflammation. Omalizumab has ...
Exercise-induced asthma is a feeling of shortness of breath, with the presence of cough, wheezing, and chest tightness after physic ...
The two strongest risk factors for asthma in childhood are a family history and immediate hypersensitivity to common allergens. ...
Vascular Endothelial Growth Factor (VEGF), originally described as a vascular permeability factor generating tissue oedema, has be ...
The sensory neuropeptides substance P and neurokinin A (NKA) are members of the tachykinin family, present within pulmonary sensory nerves and immune cells. In the airways they mainly interact with tachykinin (NK1, NK2) receptors to induce bronchoconstriction, bronchial hyperresponsiveness, mucus secretion, vasodilatation, increased vascular permeability, and attraction and activation of inflammatory cells. In this randomized, double-blind, placebocontrolled crossover multicentre trial the effects of a single dose of a dual tachykinin NK1/NK2 receptor, DNK333, were assessed on NKA-induced bronchoconstriction in asthma. (more…)
Anticholinergic agents, including nebulized glycopyrrolate, a potent but non-selective muscarinic receptor blocker, have been f ...
Leukotrienes can be found in the airway and urine following both spontaneous exacerbations of asthma and acute exposure to bron ...
The prevalence of aspirin-sensitive asthma is uncertain although it may exist in up to 20% of all asthmatics patients. The char ...
Regular use of ß-agonists has been known to lead to tolerance to their bronchodilator effects. It is not known how quickly toleranc ...
Marimastat is a synthetic broad-spectrum matrix metalloproteinase (MMP) inhibitor. This study assessed the anti-inflammatory effect ...