A variety of proinflammatory cells, mediators, and cytokines orchestrate the development of airway hyperresponsiveness, which results in the episodic airflow obstruction characteristic of asthma. As a consequence, modulation of the underlying disease process with antii-nflammatory agents is firmly established as being the cornerstone of successful management. Inhaled corticosteroids are the most potent antiinflammatory agents available and satisfactorily suppress underlying airway inflammation in most individuals. (more…)
The cysteinyl leukotrienes (LTC 4 , LTD 4 and LTE 4 ) are lipid mediators produced from an arachidonic acid precursor following ...
Antihistamines have been shown to be effective in seasonal allergic rhinitis and chronic idiopathic urticaria. They improve qua ...
In the UK, Europe and the USA, montelukast is licensed for once-daily oral administration in adults and is also available as a ...
Leukotrienes can be found in the airway and urine following both spontaneous exacerbations of asthma and acute exposure to bron ...
Despite optimum drug delivery and good compliance with inhaled corticosteroids, many patients experience symptoms and exacerbat ...
The management of asthma in the community involves patient education to avoid the triggers, doubling the dose of inhaled steroids and increasing the use of rescue medications during an exacerbation in order to prevent unnecessary hospital visits. This randomized, controlled study looks at whether doubling the dose of inhaled corticosteroid in isolation is effective when asthma deteriorates. (more…)
This study was similar to the study of Harrison and colleagues, which looked at doubling the dose of inhaled corticosteroid dur ...
The guidelines for asthma management recommend the use of regular inhaled corticosteroid in patients with mild persistent asthma, b ...
The role of oral and inhaled corticosteroids in the management of acute asthma is well known. This study compared the effects of in ...
For most patients, asthma is not controlled as defined by guidelines; whether this is achievable has not been prospectively stu ...
Patients with severe persistent asthma who are inadequately controlled despite Global Initiative for Asthma (GINA) 2002 step 4 ther ...
The symptoms of asthma occur together with variations in the diameter of medium- size airways such that it is increasingly difficult to exhale. Narrowing of the airways can occur because of smooth muscle contraction, edema or swelling of the wall, or increased mucus in the airways. However, it is increasingly clear that the pathologic event underlying most cases of asthma is acute inflammation of the airway walls. (more…)
There are other signs and symptoms of asthma. People with asthma can be feeling irritable because of asthma discomfort. Some si ...
IgE plays an important role in allergic asthma. Reducing IgE in the airway mucosa should reduce airway inflammation. Omalizumab has ...
Exercise-induced asthma is a feeling of shortness of breath, with the presence of cough, wheezing, and chest tightness after physic ...
The two strongest risk factors for asthma in childhood are a family history and immediate hypersensitivity to common allergens. ...
Vascular Endothelial Growth Factor (VEGF), originally described as a vascular permeability factor generating tissue oedema, has be ...
There have been concurrent increases in the prevalence of obesity and asthma in recent years in New Zealand and other countries. Two cross-sectional surveys performed in 1989 and 2000 were used to test this association in children of mean age 11.7 years. BMI was calculated as weight/height 2 (kg/m 2 ) and obesity and overweight defined according to an international standard. Standard questions were used to measure the prevalence of asthma symptoms. (more…)
This study investigated the possibility of sex-specificity for the association of obesity and asthma using objective measures of Bo ...
There is increasing evidence relating body mass index to the prevalence of asthma and incidence of asthma in children and adult ...
During recent decades there has been extensive epidemiological research to explore the increasing prevalence of asthma and alle ...
The prevalence of asthma increases with increasing levels of Dichlorodiphenyldichloroethylene (DDE). However, the effect of early-l ...
Breast milk contains a variety of bioactive substances, among them soluble CD14 (sCD14), which plays an important role in innat ...
Definitions of anaphylaxis vary considerably, impeding the comparison of different clinical studies. Different definitions of anaphylaxis have been developed as clinical descriptions of severe allergic reactions, different authors emphasizing different symptoms.
The author aimed to develop a simple clinical grading system and definition for anaphylaxis using clinical data. He retrospectively analyzed 1149 case records (median age 29 years) with systemic allergic reactions (30% venom allergy, 22% iatrogenic allergy, 18% food allergy) from an emergency department in Australia. (more…)
It will be helpful for you to have some understanding of the terms that are currently being used by practitioners in the field ...
Systemic allergic reactions are a relatively common clinical emergency. In their mildest form, they may just manifest as system ...
Families frequently do not use their self-injectable adrenaline device, even when their kids is experiencing a potentially life ...
Although most forms of allergy causes uncomfortable situations, an extreme allergic reaction to an allergen can eventually lead to ...
Anaphylactic reactions to Hymenoptera venom are relatively uncommon but can be life-threatening: venom immunotherapy is the treatme ...
Leukotrienes are present in increased amounts in exhaled breath condensate (EBC) in patients with asthma. So far, no data have been reported about leukotriene levels in non-asthmatic patients with Seasonal Allergic Rhinitis. The aim of the study was to find out whether the leukotriene levels in exhaled breath condensate were increased in the non-asthmatic adult patients with Seasonal Allergic Rhinitis both during and after the pollen season in comparison with healthy controls, and to assess changes in leukotriene levels after the pollen season. Twentynine non-asthmatic adult patients with Seasonal Allergic Rhinitis and 50 healthy non-smoking controls underwent measurement of exhaled leukotrienes in the exhaled breath condensate during and after the pollen season. Spirometry, skin-prick tests and total IgE were also evaluated. (more…)
Some features seem to be common to severe asthma and Chronic Obstructive Pulmonary Disease with reversibility of airflow limita ...
A role for Leukotriene B4 in the induction of airway hyper-responsiveness was explored through the use of transgenic mice defic ...
Seasonal allergic rhinitis is stimulated by an allergic reaction of human body to pollen and spores. This is much depending on ...
Adjusting the inhaled glucocorticoid dose based on indices of airway inflammation has been proposed as a means of achieving more ef ...
Treating allergic rhinitis may have a downstream effect on concomitant asthma and this may be due to attenuation of the underlying ...
Do you have a food allergy? A recent study by the U.S. government has concluded that data from the past on food allergy was not accurate at all in defining food allergy. The studies performed poorly and have a high rate of misdiagnosis. Only four percent of the adult population of the United States has a real food allergy, according to the website of the Mayo Clinic. (more…)
Gastrointestinal allergy can be classified according to the triggering antigen, the mechanism of immune reaction, or the anatom ...
Many people will tell you that they have a food allergy; in fact in today's society it is considered to be trendy, with celebri ...
Food allergies are becoming popular topics in the news at the moment. Based on a recent report by the CDC, the number of people ...
It is quite likely you've known someone with a severe allergy. From peanuts to gluten, such food allergies have grown to be much mo ...
How frequently do you drink milk everyday or every week? Feel something strange after you drink your last milk? Perhaps you don ...
Scleroderma is a disease related with body autoimmune, connective tissue disease. Scleroderma induces inflammation and thickening of the skin. In scleroderma patients, their tissues are diffuse connective tissue disease characterized by changes in the skin, blood vessels, skeletal muscles, and internal organs. (more…)
Hay fever affects millions of people around the world every year. And one of the most common and prolific triggers is grass pol ...
Children in the early of their life is prone to allergy because their body immune system is not developed completely. As a matter o ...
There are still many people that are giving consultation to others, suggest the wrong advice in the context of the treatment of bab ...
Scleroderma is a disease of unknown cause characterized by abnormally increased collagen deposition in the skin. The course is ...
Allergic reactions is natural body’s response to “foreign substance” or “invader” that potentially harmful to your body. Once ...
Asthma is a continuing problem for healthcare, particularly in the industrialized world. Some 150 million people are estimated to suffer from asthma worldwide, with 5.2 million sufferers in the UK. Hospital admissions for asthma number 69 000 per annum in the UK, including 28 500 children. Approximately 1400 people die from asthma in the UK annually, of whom over 30% are under the age of 65. Asthma costs the UK National Health Service almost £90 million per annum (statistics from Asthma UK, http://www.asthma.org.uk). (more…)
Vascular Endothelial Growth Factor (VEGF), originally described as a vascular permeability factor generating tissue oedema, has be ...
Airway hyper-responsiveness in asthma may involve smooth muscle growth, a manifestation of airway remodelling. The involvement ...
Airway remodelling is considered to be of major importance in the pathology of asthma, with subepithelial basement membrane thi ...
Contact of pathogens with the innate immune system will most frequently occur at epithelia, and the biology of the airway epitheliu ...
Some features seem to be common to severe asthma and Chronic Obstructive Pulmonary Disease with reversibility of airflow limita ...
Asthma is a big problem worldwide today. Many people who suffer from asthma do not even realize they have it until it gets out of control. They might go to the doctor with some respiratory problems and receive temporary asthma relief just to have it come back again because they were not properly diagnosed. Understanding the symptoms of asthma is vital so that you can get proper treatment for it. (more…)
Sinusitis is one inconvenience disease condition that many people had. Many drugs and antibiotics that are prescribed by your docto ...
Asthma can be worsen if it is not treated properly. If you are one of the person who are having such illness, you already knew ...
Allergies can be extremely frustrating and attack at the worst possible times. While doctors may prescribe medication to those ...
There is a lot of prescription drug usage occurring these days, and with those prescription medications, come dangerous side ef ...
Homeopathy treatment is gaining wider acceptance recently. You may look at this natural medication by trying homeopathy to help ...