Negative family characteristics such as family conflict and family dysfunction discriminated children who died of asthma from children with equally severe asthma who did not die. Parenting difficulties have been associated with a higher risk for the development of asthma early in life. In addition, children with the highest risk of developing early-onset asthma were those in families with both parenting problems and high stress. Evidence for a asthma and stress link has been demonstrated through temporal studies, as experiencing an acute negative life event increased children’s risk for an asthma attack 4 to 6 weeks after the occurrence of the event. (more…)
Learning to relax is important not only to release tension or stress but can ease your sinus and help you to copy with it. True rel ...
The two strongest risk factors for asthma in childhood are a family history and immediate hypersensitivity to common allergens. ...
Asthma is a frightening condition. I have lived with asthma symptoms for 17 years and the thought of an allergy induced asthma atta ...
Acupuncture for acne, psoriasis, allergies and related conditions is the current interest of several study groups, to investigate a ...
The genetic basis of asthma heritability has been extensively studied and the studies are yielding some understanding. There is ...
The immunologic mechanisms of sublingual immunotherapy are less established. In Cochrane analysis, the authors concluded that there was an increase in IgG4 but no stable effect on IgE levels in adults. In addition, the induction of allergen-specific IgA has been reported. There are conflicting data concerning lympho-proliferative responses. So far the evidence on changes in Th1/Th2/Treg activity induced by sublingual immunotherapy need to be confirmed. The effects on T-cell reactivity and cytokine secretion show strong variation in a number of studies. (more…)
Allergen-specific immunotherapy aims to correct the underlying immune imbalance associated with specific immunotherapy allergic rhi ...
The precise mechanisms underlying the effects of Specific Immunotherapy are not well understood but several studies have shown ...
The increasing prevalence of allergic disease in the Western world has led to the concept of the ‘allergic march’ to describe t ...
Allergen-specific immunotherapy is highly effective in the treatment of IgE-mediated allergy diseases such as rhinitis, conjunc ...
Histamine is a low-molecular-weight monoamine that binds to four different G-protein-coupled receptors, and has recently been d ...
Adjusting the inhaled glucocorticoid dose based on indices of airway inflammation has been proposed as a means of achieving more effective control of asthma than the conventional approach of adjusting steroid dose based on symptoms, lung function and rescue medication use. In a single-blind, placebo-controlled trial, 97 asthmatic patients received fluticasone doses adjusted on the basis either of conventional guidelines or of exhaled nitric oxide fraction (FE NO ). (more…)
For most patients, asthma is not controlled as defined by guidelines; whether this is achievable has not been prospectively stu ...
The new corticosteroid ciclesonide has been evaluated in various studies to assess its efficacy and adverse effect profile in a ...
Despite optimum drug delivery and good compliance with inhaled corticosteroids, many patients experience symptoms and exacerbat ...
The management of asthma in the community involves patient education to avoid the triggers, doubling the dose of inhaled steroi ...
Treating allergic rhinitis may have a downstream effect on concomitant asthma and this may be due to attenuation of the underlying ...
The geographical variation in the prevalence of asthma in children does not coincide with variations in air pollution levels. The increase in the prevalence of asthma and allergies seen over the last decades was paralleled by a decrease in emissions of SO2 and particles from coal combustion, and an increase of emissions from motor vehicle traffic. There is a growing number of studies suggesting that increased exposure to traffic exhausts, particularly diesel exhausts, may be a risk factor for the new onset of asthma. (more…)
Asthma is a complex syndrome rather than a single disease entity. Different phenotypes with varying prognosis and determinants have ...
During recent decades there has been extensive epidemiological research to explore the increasing prevalence of asthma and alle ...
Sulfur Dioxide The effects of SO2 have been extensively reviewed. Total emergency room visits for respiratory problems and ...
The effects of exposure to environmental tobacco smoke (ETS) on children have been extensively studied and numerous surveys hav ...
Atopic Dermatitis is considered to be one of the first manifestations in the atopic march. The aim of this study was to investi ...
A paradigm of immune development underlies allergy development and progression in early childhood. Briefly, the immune system of the fetus is maintained in a tolerogenic state, preventing adverse immune responses and rejection between the mother and fetus. Placental interleukin-10 (IL-10) suppresses the production of immune-potentiating inter-feron gamma (IFN-y) by fetal immune cells. IFN-y downregulates the production of pro-allergic cytokines, such as IL-4 and IL-13. (more…)
In the Tucson CRS study, about 50% of young children experienced a period of recurrent wheezing and/or coughing in the first 6 ...
Treatment with omalizumab has been shown to reduce serum free IgE concentrations and to have beneficial effects on allergic airway ...
The precise mechanisms underlying the effects of Specific Immunotherapy are not well understood but several studies have shown ...
Recently, UK Department of Health has circulated advice aimed at reducing the development of peanut allergy. The advice, base ...
Exposure and allergic sensitization to cockroach was associated with a significantly greater risk of asthma hospitalization and ...
Atopic Dermatitis is considered to be one of the first manifestations in the atopic march. The aim of this study was to investigate prospectively the natural course of Atopic Dermatitis to determine factors influencing its prognosis and to analyse the relationship of Atopic Dermatitis with childhood asthma. The Multicenter Allergy Study, a German birth cohort, followed 1314 children from birth to age 7 years. Physical examinations, parental interviews on atopic symptoms and diagnoses, and determination of specific immunoglobulin (Ig)E levels were performed regularly. (more…)
Atopic Dermatitis is a chronic relapsing skin disease. Several investigations concerning the long-term prognosis of Atopic Derm ...
The prevalence of atopic dermatitis is increasing in Western societies. The hygiene hypothesis proposes that this is due to red ...
Asthma is a complex syndrome rather than a single disease entity. Different phenotypes with varying prognosis and determinants have ...
Breast milk contains a variety of bioactive substances, among them soluble CD14 (sCD14), which plays an important role in innat ...
Atopic dermatitis is a chronic inflammatory condition of the skin which usually starts in infancy. It is sometimes called ‘atop ...
It is clear from the results of large epidemiologic studies that while atopy is a major risk factor for asthma, it is usually not sufficient by itself to drive the disease process to chronicity, as less than 25% of atopics develop persistent asthma. The situation in childhood is further complicated by an additional series of development factors, related to postnatal maturation of respiratory function. (more…)
In the Tucson CRS study, about 50% of young children experienced a period of recurrent wheezing and/or coughing in the first 6 ...
Natural history studies with the following design features provide a firm epidemiologic foundation for risk factor assessments and ...
Atopic Dermatitis is considered to be one of the first manifestations in the atopic march. The aim of this study was to investi ...
Asthma is a complex syndrome rather than a single disease entity. Different phenotypes with varying prognosis and determinants have ...
More severe asthma can persist from childhood into adulthood without remission. Another important tendency in the natural histo ...
Seasonal allergic rhinitis is stimulated by an allergic reaction of human body to pollen and spores. This is much depending on the season and region as they are carried by the wind. Your doctor may recommend you to undergo allergies medication that depends on your type of allergy rhinitis. (more…)
About twenty percent of patients who have common allergic rhinitis are also having perennial allergic rhinitis symptoms. This f ...
Leukotrienes are present in increased amounts in exhaled breath condensate (EBC) in patients with asthma. So far, no data have ...
The Hayband and Qu-Chi Band are a natural alternative to help relieve the symptoms of hay fever. There are many remedies on the ...
As a person who suffered form allergies and have a profession as family physician, I have much sympathy for those struggling with i ...
Do you find yourself feeling miserable, coughing, or sneezing at about the same time each and every year? If you do, it is impo ...
Local micro environmental factors are crucial in determining both susceptibility to vascular remodeling and the extent of angiogenesis. Major exogenous triggers of airway inflammation in asthma include viruses and inhaled aeroallergens, both of which are known to be associated with the production of angiogenic factors . These stimuli elicit reciprocal immune responses, through elaboration of Th1 and Th2 cytokines. (more…)
Vascular Endothelial Growth Factor (VEGF), originally described as a vascular permeability factor generating tissue oedema, has be ...
The airway circulation has many potential roles in asthma. The vasculature has a major influence on upper airway patency in nasal i ...
Exacerbations of asthma are frequently associated with rhinoviral infection. Rhinoviruses infect respiratory epithelial cells, ...
While our primary concern is the impact that the innate immune system has on allergic disease, it is essential to recognize that al ...
Eosinophil infiltration of the mucosa is a feature of asthmatic airways. Their adhesion to bronchial epithelial cells has been ...
It is common to find anti-food IgG antibodies circulating in blood, even in people who have no signs or history of adverse reactions to foods. In fact, some authorities think that an increase in anti-food IgG in some cases might be indicative of successful resolution of an IgE-mediated allergy. The subject of IgG-mediated food allergy is extremely complicated because of the nature of the antibody and the immunological reactions associated with it. The present knowledge about food allergy-associated IgG may be summarized as follows: (more…)
B cells The main function of B cells is to produce antibodies. Antibodies are complex molecules produced by the immune syste ...
Our current knowledge for trigger factor and food allergy intolerance is still in it infancy level. We already known that the aller ...
Having a food intolerance test is becoming increasingly popular nowadays. This is because the symptoms of indigestion, stomach ...
Antibodies which are also known as immunoglobulin are found in our blood and other bodily fluids. Antibodies are used as a mechan ...
The precise mechanisms underlying the effects of Specific Immunotherapy are not well understood but several studies have shown ...