Immunoglobulin E (IgE) Regulation and Biology

immunoglobulin e
Normally present at very low levels in plasma, antibodies of the immunoglobulin E (IgE) isotype were first discovered in 1967, decades after the description of IgA, IgG, and IM. IgE antibodies are produced primarily by plasma cells in mucosal-associated lymphoid tissue and their levels are uniformly elevated in patients suffering from atopic conditions like allergic rhinitis, asthma and atopic dermatitis. Production of allergen-specific IgE in atopic individuals is driven both by a genetic predisposition to the synthesis of this isotype as well as by environmental factors, including chronic allergen exposure. (more…)

Food Intolerance Test - Which One is Best?

food intolerance test
Having a food intolerance test is becoming increasingly popular nowadays. This is because the symptoms of indigestion, stomach cramps, headaches, insomnia and constipation are associated with food intolerance. Food intolerance or food sensitivity is much more common than food allergies. It is estimated that around 10% of people are allergic to a food, but the number is increasing between 30-60% of people with intolerance to one or more additives or chemicals allergies in food. (more…)

Seasonal Allergic Reactions – Natural Relieve and Prevention

Each year, millions of people are susceptible to seasonal allergies symptoms. The pollen of the flowers float in the air that could be much more than a trigger allergies in some people. Pollen can cause allergic reactions that people can not take into consideration. Pollen can trigger an allergic reactions in patients with allergic rhinitis and asthma. (more…)

Drug Allergy Reaction Classification – Immune Reactions

drug allergy reaction
Drug allergy reactions may be classified, at least theoretically, according to one of four implicated immunologic mechanisms, according to the scheme of Gell and Coombs:

Type I Drug Allergy Reactions

Type I reactions are the result of an IgE antibody reaction, which induces immediate-type hypersensitivity reactions. (more…)

Serodiagnosis of Bacterial Diseases

serodiagnosis bacterial diseases
Serodiagnosis of bacterial diseases is of value only in specific circumstances. IgG antibody is long-lived, and its presence, although indicative of previous infection or immunization, gives little or no information on current bacterial infection. IgM antibody is usually produced within days to a few weeks after exposure to antigen, (more…)

Antibodies and the Immune Response - Human Immune System

antibodies immune response

B cells

The main function of B cells is to produce antibodies. Antibodies are complex molecules produced by the immune system in response to antigens. As mentioned previously, antigens are foreign proteins or glycoproteins (a sugar linked to a protein) that trigger the immune response. Every living cell produces several different proteins, each unique to its own cell type and species. The antibody produced against the antigen is entirely specific to that antigen. (more…)

Antibodies in Food Sensitivity – IgG Antibody

antibody food sensitivity
It is common to find anti-food IgG antibodies circulating in blood, even in people who have no signs or history of adverse reactions to foods. In fact, some authorities think that an increase in anti-food IgG in some cases might be indicative of successful resolution of an IgE-mediated allergy. The subject of IgG-mediated food allergy is extremely complicated because of the nature of the antibody and the immunological reactions associated with it. The present knowledge about food allergy-associated IgG may be summarized as follows: (more…)

Food Allergies and Intolerance — Basic Mechanisms

food-allergy-food-intoleranceOur current knowledge for trigger factor and food allergy intolerance is still in it infancy level. We already known that the allergic intolerance are different for groups of people. Some individuals are less resistant in developing allergy than others. Allergic sensitivity or atopic allergic disease are heritable and this means that genetic factors is playing a critical role. But the latest researches reveal that it is not merely heredity factors, environmental also have significant impact for someone to develop allergy.

Allergy trigger in the form of food allergen are mostly fallen to some certain foods like milk, egg, peanuts, fish, soya and nuts. We are curios on what is so peculiar about allergens in food? (more…)

Drug Allergy and Adverse Drug Reactions from Immunologic Basic Perspective

drug allergy drug sensitivity
Drug allergy and adverse drug reactions are common among many people. Those side affect of consuming drugs affecting an about 30% of hospitalized patients. Unintended and undesired reactions of consuming drugs may be immunologic or non immunologic nature. The latter let in drug toxicity, side effects, food intolerance symptoms, and idiosyncratic reactions, popular known as drug allergy. (more…)

The Basic of Food Allergy | Food Sensitivity Symptoms

food-allergy-food-sensitivityIt is estimated that more than 12 millions of American are having food allergy. About 4 percent of adults are having this disease and nearly 6 to 9 percent children under the age of 3 are having the same illness. The prevalence of food allergies is rising, where the most common food allergy in children are caused by milk allergy in children, eggs, peanuts allergy and tree nuts. In adults, the most common allergic reaction are triggered by peanuts, tree nuts, shellfish, fish and eggs. (more…)

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