The specific treatment of allergy has previously relied upon allergen avoidance and sublingual immunotherapy. These approaches have been used predominantly in hymenoptera venom and aero-allergen-driven disease when previous food allergy immunotherapy has been unsuccessful. (more…)
The precise mechanisms underlying the effects of Specific Immunotherapy are not well understood but several studies have shown ...
Allergen-specific immunotherapy aims to correct the underlying immune imbalance associated with specific immunotherapy allergic rhi ...
Histamine is a low-molecular-weight monoamine that binds to four different G-protein-coupled receptors, and has recently been d ...
Allergen-specific immunotherapy is highly effective in the treatment of IgE-mediated allergy diseases such as rhinitis, conjunc ...
The increasing prevalence of allergic disease in the Western world has led to the concept of the ‘allergic march’ to describe t ...
Airway hyper-responsiveness in asthma may involve smooth muscle growth, a manifestation of airway remodelling. The involvement of inflammatory cells in the induction of airway smooth muscle growth was studied in vivo and ex vivo in a brown Norway rat model of asthma. Transfer of CD4 + T lymphocytes from ovalbuminsensitized animals induced an increase in airway smooth muscle mass in naive animals upon repeated ovalbumin challenge. Ex vivo, coculture of antigen-stimulated CD4 + T cells and airway smooth muscle cells led to myocyte proliferation and prolonged T-cell survival. (more…)
Vascular Endothelial Growth Factor (VEGF), originally described as a vascular permeability factor generating tissue oedema, has be ...
Toll-like receptors (TLRs) act as receptors for numerous stimuli of immune cells, including bacterial cell wall constituents (l ...
A role for Leukotriene B4 in the induction of airway hyper-responsiveness was explored through the use of transgenic mice defic ...
IgE plays an important role in allergic asthma. Reducing IgE in the airway mucosa should reduce airway inflammation. Omalizumab has ...
Eosinophil infiltration of the mucosa is a feature of asthmatic airways. Their adhesion to bronchial epithelial cells has been ...
It is quite likely you’ve known someone with a severe allergy. From peanuts to gluten, such food allergies have grown to be much more common in recent decades. Fortunately, severe food allergy awareness has improved too. Food allergies are no laughing matter; many people need to be rushed to the emergency room or risk their very lives over these foods.
A few individuals go through food intolerance rather than a food allergic reaction which may cause confusion; they are distinct conditions which may trigger different responses. (more…)
At health food stores, customers are complaining about food allergies more often now with statements like, "I can't eat this", or " ...
Food allergies are becoming popular topics in the news at the moment. Based on a recent report by the CDC, the number of people ...
How frequently do you drink milk everyday or every week? Feel something strange after you drink your last milk? Perhaps you don ...
Many people will tell you that they have a food allergy; in fact in today's society it is considered to be trendy, with celebri ...
In theory, any kind of food is having the capability to trigger food allergic reaction in our body. All foods contain molecul ...
Acute inflammatory response constitute the first line of defense against infection pathogenesis and how immune system works as well as the initial stage in restoring injured tissue to normalcy. Acute inflammation is recognized by redness, swelling, heat and pain in the affected area. These symptoms stem from a multitude of events taking place within the inflamed site. The humoral arm of the immune response, including circulating antibodies and the complement system, is activated. (more…)
Once it is tethered onto the venule wall, the neutrophil or other leukocyte comes into contact with a wide variety of inflammatory ...
Some of the immediate sequelae of injury are uncomfortably familiar: Soon after an injury occurs, the affected site and its sur ...
Neutrophils make up an army of more-or-less identical circulating phagocytes that are poised to respond quickly and in vast numbers ...
The response to injury usually begins with dilatation of small blood vessels in and around the injured site (figure bellow). Th ...
The airway circulation has many potential roles in asthma. The vasculature has a major influence on upper airway patency in nasal i ...