A role for Leukotriene B4 in the induction of airway hyper-responsiveness was explored through the use of transgenic mice deficient in the BLT1 receptor for LTB4 . Ovalbumin challenge of sensitized wild-type mice resulted in the usual features of experimental asthma, including goblet cell hyperplasia, hyper-responsiveness to inhaled methacholine and elevated BAL fluid concentrations of the Th2 cytokine IL-13. In contrast, BLT1 –/– mice (i.e. genetically modified mice lacking the gene coding for the BLT1 receptor) exhibited significantly lower responses. BLT1 –/– mice also exhibited lower numbers of IL-13-positive T lymphocytes of both the helper (CD4 T Cells) and cytotoxic/suppressor (CD8 + ) types. (more…)
Vascular Endothelial Growth Factor (VEGF), originally described as a vascular permeability factor generating tissue oedema, has be ...
Airway hyper-responsiveness in asthma may involve smooth muscle growth, a manifestation of airway remodelling. The involvement ...
IgE plays an important role in allergic asthma. Reducing IgE in the airway mucosa should reduce airway inflammation. Omalizumab has ...
Some features seem to be common to severe asthma and Chronic Obstructive Pulmonary Disease with reversibility of airflow limita ...
Antihistamines have been shown to be effective in seasonal allergic rhinitis and chronic idiopathic urticaria. They improve qua ...
Airway hyper-responsiveness in asthma may involve smooth muscle growth, a manifestation of airway remodelling. The involvement of inflammatory cells in the induction of airway smooth muscle growth was studied in vivo and ex vivo in a brown Norway rat model of asthma. Transfer of CD4 + T lymphocytes from ovalbuminsensitized animals induced an increase in airway smooth muscle mass in naive animals upon repeated ovalbumin challenge. Ex vivo, coculture of antigen-stimulated CD4 + T cells and airway smooth muscle cells led to myocyte proliferation and prolonged T-cell survival. (more…)
Vascular Endothelial Growth Factor (VEGF), originally described as a vascular permeability factor generating tissue oedema, has be ...
Toll-like receptors (TLRs) act as receptors for numerous stimuli of immune cells, including bacterial cell wall constituents (l ...
A role for Leukotriene B4 in the induction of airway hyper-responsiveness was explored through the use of transgenic mice defic ...
IgE plays an important role in allergic asthma. Reducing IgE in the airway mucosa should reduce airway inflammation. Omalizumab has ...
Eosinophil infiltration of the mucosa is a feature of asthmatic airways. Their adhesion to bronchial epithelial cells has been ...
Many people are under impression that allergy and asthma disease had genetic or heredity factors playing major role as medium of transferred. If parents have allergy, then there is a big chances that their kids will and soon develop allergy in some stage of their live. Some even elaborate this heredity factors to other closed family relatives. (more…)
Children in the early of their life is prone to allergy because their body immune system is not developed completely. As a matter o ...
Hay fever affects millions of people around the world every year. And one of the most common and prolific triggers is grass pol ...
There are still many people that are giving consultation to others, suggest the wrong advice in the context of the treatment of bab ...
Our current knowledge for trigger factor and food allergy intolerance is still in it infancy level. We already known that the aller ...
Allergic reactions is natural body’s response to “foreign substance” or “invader” that potentially harmful to your body. Once ...