The genetic basis of asthma heritability has been extensively studied and the studies are yielding some understanding. There is, as yet, no set genetic pattern that predicts presence of asthma or defines it severity. There are usually reasons or risk of asthma factors that makes someone susceptible to asthma and respiratory allergy problems. Asthma doesn’t just happen randomly to anyone without asthma gene factors risk factors.

Let’s consider some asthma risk factors and see how they increase the chance that a individual will have the asthma signs or symptoms of cough, wheezing, as well as shortness of breathing associated with the disease. After determining your personal risk factors for asthma, decide on the ones you can control as well as try to make some lifestyle changes. Avoidance of the risk factors you can control is important in preventing asthma symptoms. While you cannot change your own gender to family history, you can avoid smoking with asthma, breathing polluted air, and obesity. Take control of your asthma by controlling the asthma risk factors. By understanding all of the risk factors, you are able to prevent to control your asthma.

Genetic factors cannot explain the rise in asthma prevalence, morbidity, or mortality. However, a small change in the prevalence of relevant environmental exposures could explain a significant rise in disease prevalence among genetically susceptible individuals. Gene-environment interaction, defined as the co-participation of genetic and environmental factors, is particularly relevant to the etiology of asthma morbidity, especially in individuals who experience a disproportionate burden of environmental exposures. Relevant exposures include smoking, stress, nutritional factors, infections, allergens, and occupational asthma exposures. In addition, racial/ethnic variability in the distribution of genetic polymorphisms can potentially modify the response to pharmacotherapeutic agents, such as the ß 2 -adrenergic receptor. A genetic polymorphism in the ß 2 -adrenergic receptor gene has been associated with asthma severity, as well as with the susceptibility to develop asthma among individuals who smoked.

Childhood asthma happens more frequently in boys than in girls. It is still not known precisely why this occurs even though some experts find a young male’s airway size is small compared to the female’s airway, that may contribute to increased risk of wheezing after a cold or perhaps other viral infection. Around age 20, the ratio of asthma between people is the same. At age 40, more females than men have adult asthma.

The inherited genetic makeup predisposes you to having asthma. In fact, it’s thought that three-fifths of all asthma cases are hereditary. Based on CDC report, if a person has a parent with asthma, there is 3 to 6 times more probably to develop asthma than someone who does definitely not have a parent with asthma.

The Tcell Ig domain and mucin domain (TIM) proteins, the genes for which are located on chromosome 5q, have been suggested to be involved in allergic disease. This study examined allergies genetic association of sequence variants of the TIM1 and TIM3 genes in an African-American population. Case–control and family based association analyses were performed for three SNPs each in the TIM1 and TIM3 genes, and an insertion/deletion polymorphism in Tcell Ig domain and mucin domain 1. (more…)

Although ADAM33 was the first gene identified by positional cloning to underlie the risk factor of asthma, attempts to replicate the original results have had inconsistent results. In this report, the authors aim to clarify the role of ADAM33 in asthma by expanding the size of the informative populations and cumulatively analyzing data from relevant published studies. ADAM33 SNPs were genotyped in 60 nuclear families from England recruited from an asthma outpatient clinic, as well as 348 unrelated asthma cases and 262 non-asthmatic controls in an Icelandic population. (more…)

Allergy and asthma are surrounding many of us. People suffer from various allergy and asthma that are caused by food, dust, and sometimes flowers. This is a situation where our immune system reacts to some natural substances and causes discomfort. Asthma on the other hand happens when the bronchial muscles get tensed making the windpipe congested and resulting in breathing problems. (more…)

The manifestations of asthma and allergy are the result of both genetic predisposition and environmental factors. This relationship between genes and the environment is complex and has been the subject of intense investigation in recent years. The predisposition to asthma, unlike that to diseases determined by a single gene, is genetically complex. Consequently, it is thought that a number of genes, each with a relatively small contribution, collectively produce an individual’s genetic susceptibility profile. (more…)

Many people are under impression that allergy and asthma disease had genetic or heredity factors playing major role as medium of transferred. If parents have allergy, then there is a big chances that their kids will and soon develop allergy in some stage of their live. Some even elaborate this heredity factors to other closed family relatives. (more…)