The molecular basis of Common Variable Immunodeficiency (CVID) is unknown and the diagnosis requires the exclusion of other diseases known to cause primary antibody deficiency syndromes, such as X-linked lymphoproliferative disease (XLP). XLP is a rare primary immunodeficiency disease in which severe immune dysregulatory phenomena occur, typically after exposure to Epstein–Barr virus (EBV). The defective gene in XLP is SAP (SLAM associated protein, where SLAM is signalling lymphocyte activation molecule), a small SH2 domain containing protein involved in signal transduction events downstream of the SLAM family of receptors. (more…)
Common Variable Immunodeficiency (CVID) is the most frequent primary immunodeficiency in man that requires medical intervention. Mo ...
Primary immunodeficiencies occur with a frequency approaching that of cystic fibrosis (1:2500 live births). However, because they a ...
Acute phase proteins and the acute phase response in general arc stably conserved in evolution and are universal within each specie ...
Most acute phase proteins are synthesized in the liver, although the genes for some are also expressed in cells and tissues els ...
The Tcell Ig domain and mucin domain (TIM) proteins, the genes for which are located on chromosome 5q, have been suggested to b ...
Natural killer cells: history and current status
Natural killer cells are a major component of the immune system, which play important roles in host defense against cancer and microbial infections. Natural killer cells are distinct from T or B lymphocytes, with a characteristic morphology of large granular cells, and can be readily identified by characteristic cell surface molecules. (more…)
The body's innate resistance to many pathogens is provided by enzymes and other proteins in the blood and tissue fluids. These ...
Innate immunity depends on both resident and recruited leukocytes. The macrophage without doubt plays an import- ant role in the de ...
Some of the immediate sequelae of injury are uncomfortably familiar: Soon after an injury occurs, the affected site and its sur ...
Regulatory T cells Treg (picture above) is the existence of suppressor cells, which limit ongoing immune responses and prevent ...
Contact of pathogens with the innate immune system will most frequently occur at epithelia, and the biology of the airway epitheliu ...
Sulfur Dioxide
The effects of SO2 have been extensively reviewed. Total emergency room visits for respiratory problems and increased hospital admission rates have been linked with increased ambient exposure to SO2. In children, decreased lung function has been linked to increases in ambient sulfur dioxide levels and the likelihood (more…)
Recent data show that monitoring of exposure to acid aerosols is widespread in North America, the associations in a joint statement ...
The geographical variation in the prevalence of asthma in children does not coincide with variations in air pollution levels. The i ...
Environmental pollution not only makes asthma worse we are, but could make asthma inhalers were less effective. It is the conclu ...
The Misery Of Allergies As a young boy I was one of the kids who had to stay indoors to avoid the misery that came with snee ...
The two strongest risk factors for asthma in childhood are a family history and immediate hypersensitivity to common allergens. ...