The immunologic mechanisms of sublingual immunotherapy are less established. In Cochrane analysis, the authors concluded that there was an increase in IgG4 but no stable effect on IgE levels in adults. In addition, the induction of allergen-specific IgA has been reported. There are conflicting data concerning lympho-proliferative responses. So far the evidence on changes in Th1/Th2/Treg activity induced by sublingual immunotherapy need to be confirmed. The effects on T-cell reactivity and cytokine secretion show strong variation in a number of studies. (more…)
Allergen-specific immunotherapy aims to correct the underlying immune imbalance associated with specific immunotherapy allergic rhi ...
The precise mechanisms underlying the effects of Specific Immunotherapy are not well understood but several studies have shown ...
The increasing prevalence of allergic disease in the Western world has led to the concept of the ‘allergic march’ to describe t ...
Allergen-specific immunotherapy is highly effective in the treatment of IgE-mediated allergy diseases such as rhinitis, conjunc ...
Histamine is a low-molecular-weight monoamine that binds to four different G-protein-coupled receptors, and has recently been d ...
Treg cells or regulatory T cells constitute a large population of cellular infiltrate in atopic/allergic inflammation and a dysregulated immune response appears to be an important pathogenetic factor. Cardinal events during allergic inflammation can be classified as activation, organ-selective homing, survival and reactivation, and effector functions of immune system cells. T cells are activated by aeroallergens, food antigens, autoantigens, and bacterial exotoxins superantigens in allergic inflammation. They are under the influence of the skin, lung, or nose-related chemokine network and show organ-selective homing. (more…)
Allergen-specific immunotherapy is highly effective in the treatment of IgE-mediated allergy diseases such as rhinitis, conjunc ...
The induction of immune tolerance and specific immune suppression are essential processes in the control of immune responses. R ...
The intracellular forkhead winged transcription factor Foxp3 (forkhead box P3) appears to be specifically expressed by naturall ...
An emerging concept is that pro-inflammatory signals lead to loss of Regulatory T Cells (Treg) function. Pasare and Medzhitov ( ...
Regulatory T cells Treg (picture above) is the existence of suppressor cells, which limit ongoing immune responses and prevent ...
Allergen-specific immunotherapy is highly effective in the treatment of IgE-mediated allergy diseases such as rhinitis, conjunctivitis, asthma, and venom allergy hypersensitivity. It is the only treatment that leads to lifelong tolerance against previously disease-causing allergens due to restoration of the normal immunity. (more…)
Allergen-specific immunotherapy aims to correct the underlying immune imbalance associated with specific immunotherapy allergic rhi ...
Histamine is a low-molecular-weight monoamine that binds to four different G-protein-coupled receptors, and has recently been d ...
The precise mechanisms underlying the effects of Specific Immunotherapy are not well understood but several studies have shown ...
Treg cells or regulatory T cells constitute a large population of cellular infiltrate in atopic/allergic inflammation and a dys ...
The immunologic mechanisms of sublingual immunotherapy are less established. In Cochrane analysis, the authors concluded that t ...
Treating allergic rhinitis may have a downstream effect on concomitant asthma and this may be due to attenuation of the underlying inflammatory process.
Fexofenadine and montelukast exhibited additive effects to moderately high doses of inhaled corticosteroids when used as add-on therapy in the treatment of patients with persistent atopic asthma. (more…)
Despite optimum drug delivery and good compliance with inhaled corticosteroids, many patients experience symptoms and exacerbat ...
The role of oral and inhaled corticosteroids in the management of acute asthma is well known. This study compared the effects of in ...
Montelukast has proven efficacy in the treatment of chronic asthma and seasonal allergic rhinitis, but it has not been evaluate ...
Roflumilast is an oral, once-daily PDE4 inhibitor with antiinflammatory activity in development for the treatment of asthma. Ro ...
Current internationally recognized guidelines indicate that symptomatic asthmatics using a low to medium inhaled corticosteroid ...
The most crucial element in the assessment process of a possible allergic problem is patient’s allergy history. An allergy history is made up of a chief problem, resolve of seasonality or diurnal variation of symptoms, detection of triggers, occupational asthma exposure, and reaction to medicines, family history, and some other relevant medical history. An allergy history looks for to define the patient’s chief complaint(s) and concentrates on the details with regards to those complaints. There is a lexicon typical to patients with allergy complaints. Sinus dizziness strain and headaches are often cited as symptoms. The history taker should be attuned to the patient’s viewpoint as a possible allergy sufferer. Exactly where and when does the symptom happen? Or is it happened during sleep? (more…)
Patient’s allergy history is one of the most important elements to evaluate of possible allergic problem. Sometimes this import ...
If you have sinusitis, one of the displeasing aspects of sinusitis is dizziness condition that comes with it. Symptoms of sin ...
Are there any complications with Allergic rhinitis? At first glance, the symptoms of allergic rhinitis may not appear unduly troub ...
Allergy skin testing is probably the most susceptible and practical way to monitor for existing allergy sensitivity. Biological ...
Classification of bronchial asthma can be based on age, etiology, associated characteristics, or severity. Classifications base ...
Leukotrienes are present in increased amounts in exhaled breath condensate (EBC) in patients with asthma. So far, no data have been reported about leukotriene levels in non-asthmatic patients with Seasonal Allergic Rhinitis. The aim of the study was to find out whether the leukotriene levels in exhaled breath condensate were increased in the non-asthmatic adult patients with Seasonal Allergic Rhinitis both during and after the pollen season in comparison with healthy controls, and to assess changes in leukotriene levels after the pollen season. Twentynine non-asthmatic adult patients with Seasonal Allergic Rhinitis and 50 healthy non-smoking controls underwent measurement of exhaled leukotrienes in the exhaled breath condensate during and after the pollen season. Spirometry, skin-prick tests and total IgE were also evaluated. (more…)
Some features seem to be common to severe asthma and Chronic Obstructive Pulmonary Disease with reversibility of airflow limita ...
A role for Leukotriene B4 in the induction of airway hyper-responsiveness was explored through the use of transgenic mice defic ...
Seasonal allergic rhinitis is stimulated by an allergic reaction of human body to pollen and spores. This is much depending on ...
Adjusting the inhaled glucocorticoid dose based on indices of airway inflammation has been proposed as a means of achieving more ef ...
Treating allergic rhinitis may have a downstream effect on concomitant asthma and this may be due to attenuation of the underlying ...
Food allergies are becoming popular topics in the news at the moment. Based on a recent report by the CDC, the number of people with food allergies has grown 20 percent in the last ten years. Only three percent of Americans could correctly distinguish four of the common list of food allergens (peanuts, dairy products, eggs and wheat). But still the main problem is on how to identify food allergies easily? (more…)
Having a food intolerance test is becoming increasingly popular nowadays. This is because the symptoms of indigestion, stomach ...
It is quite likely you've known someone with a severe allergy. From peanuts to gluten, such food allergies have grown to be much mo ...
Many people will tell you that they have a food allergy; in fact in today's society it is considered to be trendy, with celebri ...
Do you have a food allergy? A recent study by the U.S. government has concluded that data from the past on food allergy was not ...
At health food stores, customers are complaining about food allergies more often now with statements like, "I can't eat this", or " ...
As a person who suffered form allergies and have a profession as family physician, I have much sympathy for those struggling with itchy, watery eyes, coughing, stuffy nose, postnasal drip, or allergies hay fever and cough. Like spring and summer that can take months, allergies patients have to find a way on how to survive in this season. (more…)
If the onset of summer brings with it itchy eyes, a runny nose and sneezing then it is very likely that you suffer from hayfeve ...
The Hayband and Qu-Chi Band are a natural alternative to help relieve the symptoms of hay fever. There are many remedies on the ...
Hay fever affects millions of people around the world every year. And one of the most common and prolific triggers is grass pol ...
Experts say heavy rains in recent months will cause allergic reaction to six million peopla that is in our country live a diffi ...
Do you find yourself feeling miserable, coughing, or sneezing at about the same time each and every year? If you do, it is impo ...
Seasonal allergic rhinitis is stimulated by an allergic reaction of human body to pollen and spores. This is much depending on the season and region as they are carried by the wind. Your doctor may recommend you to undergo allergies medication that depends on your type of allergy rhinitis. (more…)
About twenty percent of patients who have common allergic rhinitis are also having perennial allergic rhinitis symptoms. This f ...
Leukotrienes are present in increased amounts in exhaled breath condensate (EBC) in patients with asthma. So far, no data have ...
The Hayband and Qu-Chi Band are a natural alternative to help relieve the symptoms of hay fever. There are many remedies on the ...
As a person who suffered form allergies and have a profession as family physician, I have much sympathy for those struggling with i ...
Do you find yourself feeling miserable, coughing, or sneezing at about the same time each and every year? If you do, it is impo ...
It is now almost a century since the pioneering work of Noon and Freeman was used to successfully treat hay fever symptoms using a low-dose incremental schedule of pollen injections. Noon based his doses of pollen extract on a pollen weight unit that remained in use for over 70 years; (more…)
Allergen-specific immunotherapy aims to correct the underlying immune imbalance associated with specific immunotherapy allergic rhi ...
The safety of immunotherapy has been a constraint on this form of treatment for allergic disease. Although retrospective survey ...
Anaphylactic reactions to Hymenoptera venom are relatively uncommon but can be life-threatening: venom immunotherapy is the treatme ...
Specific immunotherapy has been widely used to treat allergic rhinitis symptoms. As with any other form of specific immunotherapy, ...
Allergic rhinitis is a very common problem associated with poor quality of life, reductions in social and work activities and p ...