Allergic Rhinitis and Asthma: Genetic Linkage Regions

allergic rhinitis asthma
Allergic rhinitis and asthma are common comorbidities. Like asthma, the presence of a genetic component in allergic rhinitis has been well established. To identify genetic linkage regions unique to allergic rhinitis, as well as those shared by allergic rhinitis and asthma, a genome screen study was conducted. A total of 295 families in the French Epidemiological Study on the Genetics and Environment of Asthma (EGEA) containing 1317 subjects were genotyped for 396 microsatellite markers. The families included had two siblings with DNA available and at least one asthmatic subject. Three definitions of allergic rhinitis were used, two binary and one categorical. To investigate linkages specific to allergic rhinitis (without asthma), linkage analyses were also conducted in 185 families with at most one asthmatic sib. (more…)

Allergy and Asthma – Are They Genetically Inherited?

allergy asthma genetical inherited
Many people are under impression that allergy and asthma disease had genetic or heredity factors playing major role as medium of transferred. If parents have allergy, then there is a big chances that their kids will and soon develop allergy in some stage of their live. Some even elaborate this heredity factors to other closed family relatives. (more…)