With the help of well-trained and experienced pulmonary function technicians, children as young as 4 to 5 years of age should be capable of performing spirometry. Spirometry measures forced vital capacity (FVC), forced expiratory volume in 1 second (FEV 1 ), the ratio of FEV 1 /FVC, as well as other measures of airflow including the forced expiratory flow between 25% and 75% of FVC (FEF 25–75 ). The FEV 1 is the most commonly used and reproducible measure of pulmonary function, whereas the FEF 25–75 demonstrates much more intrapatient variability. (more…)
The role of oral and inhaled corticosteroids in the management of acute asthma is well known. This study compared the effects of in ...
Vocal cord dysfunction (VCD) is a functional respiratory tract disorder resulting from paradoxical adduction of the vocal cords ...
More severe asthma can persist from childhood into adulthood without remission. Another important tendency in the natural histo ...
Tumour necrosis factor alpha (TNF-a) is a major therapeutic target in a range of chronic inflammatory disorders involving neutr ...
Allergen avoidance has been recommended in the management of allergic asthma children. Very few studies have assessed the effect of ...
This study was similar to the study of Harrison and colleagues, which looked at doubling the dose of inhaled corticosteroid during an asthma exacerbation. This study investigated whether doubling the dose of budesonide inhalation in patients on regular inhaled budesonide would be beneficial during an asthma exacerbation. (more…)
The management of asthma in the community involves patient education to avoid the triggers, doubling the dose of inhaled steroi ...
The guidelines for asthma management recommend the use of regular inhaled corticosteroid in patients with mild persistent asthma, b ...
Asthma control is improved by combining inhaled corticosteroids with long acting beta-agonists but patients still require relie ...
This study evaluated budesonide formoterol efficacy and safety of a novel asthma management strategy for both maintenance and s ...
The role of oral and inhaled corticosteroids in the management of acute asthma is well known. This study compared the effects of in ...
Treating allergic rhinitis may have a downstream effect on concomitant asthma and this may be due to attenuation of the underlying inflammatory process.
Fexofenadine and montelukast exhibited additive effects to moderately high doses of inhaled corticosteroids when used as add-on therapy in the treatment of patients with persistent atopic asthma. (more…)
Despite optimum drug delivery and good compliance with inhaled corticosteroids, many patients experience symptoms and exacerbat ...
The role of oral and inhaled corticosteroids in the management of acute asthma is well known. This study compared the effects of in ...
Montelukast has proven efficacy in the treatment of chronic asthma and seasonal allergic rhinitis, but it has not been evaluate ...
Roflumilast is an oral, once-daily PDE4 inhibitor with antiinflammatory activity in development for the treatment of asthma. Ro ...
Current internationally recognized guidelines indicate that symptomatic asthmatics using a low to medium inhaled corticosteroid ...
The T-bet (T-box 21) gene (TBX21) encodes a transcription factor, T-box expressed in T cells, which has been implicated in asthma through its role in Th1 cell induction. Subjects in the Caucasian subset of the Childhood Asthma Management Program (CAMP) were genotyped for a non-synonymous TBX21 SNP, H33Q. Comparisons between the wild-type and heterozygous H33Q alleles were performed by luciferase activity assay and by studying the ability to control cytokine function in cell culture. The effect of corticosteroids on T-bet expression was determined in human peripheral blood CD4-positive cells. (more…)
Increasing evidence demonstrates that cytokines of Th1 and Th2 cells play important roles in allergic disorders. This study exa ...
Allergen avoidance has been recommended in the management of allergic asthma children. Very few studies have assessed the effect of ...
The Tcell Ig domain and mucin domain (TIM) proteins, the genes for which are located on chromosome 5q, have been suggested to b ...
Although ADAM33 was the first gene identified by positional cloning to underlie the risk factor of asthma, attempts to replicate th ...
A previous genome-wide screen for mite-sensitive atopic dermatitis asthma in Japanese families indicated linkage to chromosome 5q33 ...
How to properly make clinical diagnosis of acute severe asthma? There is little doubt of the accuracy of current asthma testing. This is because most patients had bring out an established asthma diagnosis from prior regular asthma treatment, before presenting it to Asthma Emergency Department. We can see that most of patients had physical presentation: sitting up right, had profusely diaphoretic, only manage to speak only a few words at a time, and obvious respiratory distress. We can see varying respiratory rate on most patients. Hyperventilating is common in proportion to the severity of asthma attack. On the other hand, patients with hypoventilation is an indication of impending respiratory arrest. (more…)
The role of oral and inhaled corticosteroids in the management of acute asthma is well known. This study compared the effects of in ...
In 2004, there were 2.4 million children aged 5 to 14 years, or 5.9% of this population group, with a self-reported asthma atta ...
Asthma is a frightening condition. I have lived with asthma symptoms for 17 years and the thought of an allergy induced asthma atta ...
Vocal cord dysfunction (VCD) is a functional respiratory tract disorder resulting from paradoxical adduction of the vocal cords ...
This study evaluated budesonide formoterol efficacy and safety of a novel asthma management strategy for both maintenance and s ...