Current internationally recognized guidelines indicate that symptomatic asthmatics using a low to medium inhaled corticosteroid dose (400–800 µg/day of beclomethasone or equivalent) alone should preferentially be commenced on a long-acting agonist ß2 prior to an leukotriene receptor antagonists LTRA (British guideline on the management of asthma 2003; GINA Workshop Report 2004). However, two recent large trials have performed head to-head comparisons of add-on long-acting ß2 agonist versus LTRA as therapeutic adjuncts to inhaled corticosteroids, using exacerbation frequency (rather than lung function and symptoms) as the primary end point. (more…)
Leukotrienes can be found in the airway and urine following both spontaneous exacerbations of asthma and acute exposure to bron ...
Despite optimum drug delivery and good compliance with inhaled corticosteroids, many patients experience symptoms and exacerbat ...
Two long-acting ß 2 -adrenergic agonists (LABAs), salmeterol and formoterol, have been demonstrated to be safe and effective ag ...
Treating allergic rhinitis may have a downstream effect on concomitant asthma and this may be due to attenuation of the underlying ...
Regular use of ß-agonists has been known to lead to tolerance to their bronchodilator effects. It is not known how quickly toleranc ...
Allergen-specific immunotherapy is highly effective in the treatment of IgE-mediated allergy diseases such as rhinitis, conjunctivitis, asthma, and venom allergy hypersensitivity. It is the only treatment that leads to lifelong tolerance against previously disease-causing allergens due to restoration of the normal immunity. (more…)
Allergen-specific immunotherapy aims to correct the underlying immune imbalance associated with specific immunotherapy allergic rhi ...
Histamine is a low-molecular-weight monoamine that binds to four different G-protein-coupled receptors, and has recently been d ...
The precise mechanisms underlying the effects of Specific Immunotherapy are not well understood but several studies have shown ...
Treg cells or regulatory T cells constitute a large population of cellular infiltrate in atopic/allergic inflammation and a dys ...
The immunologic mechanisms of sublingual immunotherapy are less established. In Cochrane analysis, the authors concluded that t ...
Normally present at very low levels in plasma, antibodies of the immunoglobulin E (IgE) isotype were first discovered in 1967, decades after the description of IgA, IgG, and IM. IgE antibodies are produced primarily by plasma cells in mucosal-associated lymphoid tissue and their levels are uniformly elevated in patients suffering from atopic conditions like allergic rhinitis, asthma and atopic dermatitis. Production of allergen-specific IgE in atopic individuals is driven both by a genetic predisposition to the synthesis of this isotype as well as by environmental factors, including chronic allergen exposure. (more…)
The precise mechanisms underlying the effects of Specific Immunotherapy are not well understood but several studies have shown ...
Our current knowledge for trigger factor and food allergy intolerance is still in it infancy level. We already known that the aller ...
Treatment with omalizumab has been shown to reduce serum free IgE concentrations and to have beneficial effects on allergic airway ...
A paradigm of immune development underlies allergy development and progression in early childhood. Briefly, the immune system o ...
IgE plays an important role in allergic asthma. Reducing IgE in the airway mucosa should reduce airway inflammation. Omalizumab has ...
Diagnosis of food hypersensitivity is a clinical challenge and the only current definitive test is the Double Blind Placebo-Controlled Food Challenges. Although the Double Blind Placebo-Controlled Food Challenges is the current gold standard, it is difficult to perform and is very time-consuming. Hence, researchers are continually evaluating new tests and assessing the value of the available serum tests. (more…)
The food eating challenges materials used at different centers vary considerably. Some centers use freeze-dried foods, some use con ...
Over the last 5 years some studies have suggested that the atopy patch test (APT) may be a useful test in atopic dermatitis childre ...
The diagnostic approach to allergic food reactions comprises three steps. The first step includes the medical allergy history, ...
This population-based cross-sectional study, funded by a UK government agency, aimed to establish the rate of sensitization to food ...
If you suspect that certain foods trigger wheezing or asthma symptoms in your child, your first action should be a consultation ...
Over the last 5 years some studies have suggested that the atopy patch test (APT) may be a useful test in atopic dermatitis children who have suspected food hypersensitivity and may even obviate the need for oral challenges. An alternative test to oral allergy challenges with high sensitivity and specificity would be helpful in the diagnosis of food hypersensitivity. (more…)
One of the popular allergy testing besides food allergy testing is skin allergy testing. Allergy patch test is the most commo ...
Diagnosis of food hypersensitivity is a clinical challenge and the only current definitive test is the Double Blind Placebo-Control ...
This population-based cross-sectional study, funded by a UK government agency, aimed to establish the rate of sensitization to food ...
The diagnostic approach to allergic food reactions comprises three steps. The first step includes the medical allergy history, ...
The food eating challenges materials used at different centers vary considerably. Some centers use freeze-dried foods, some use con ...
The food eating challenges materials used at different centers vary considerably. Some centers use freeze-dried foods, some use concentrated foods masked in other foods or capsules, and some use freshly prepared foods. This study aimed to develop and validate a number of recipes for Double Blind Placebo Control Food Challenges in Children. Common allergenic foods, cow’s milk, egg, soy, peanut, hazelnut and wheat were used where possible in their usual edible form. (more…)
Diagnosis of food hypersensitivity is a clinical challenge and the only current definitive test is the Double Blind Placebo-Control ...
This population-based cross-sectional study, funded by a UK government agency, aimed to establish the rate of sensitization to food ...
Many people affected with celiac disease have no idea what's going on until they have gone through years of painful diarrhea, b ...
If you suspect that certain foods trigger wheezing or asthma symptoms in your child, your first action should be a consultation ...
Over the last 5 years some studies have suggested that the atopy patch test (APT) may be a useful test in atopic dermatitis childre ...
There is increasing evidence relating body mass index to the prevalence of asthma and incidence of asthma in children and adults, males, and more consistently, in adolescent females. It is unlikely that the association is attributable to reverse causation, i.e. that asthma and obesity because of exercise-induced asthma symptoms. Rather, weight gain can antedate the development of asthma. Weight reduction among asthmatic patients can also result in improvements of lung function. (more…)
There have been concurrent increases in the prevalence of obesity and asthma in recent years in New Zealand and other countries ...
Asthma as disease affects approximately 15 million people in the United States alone. Asthma affected 70 percent more women tha ...
Breast milk contains a variety of bioactive substances, among them soluble CD14 (sCD14), which plays an important role in innat ...
The most important aspect of managing food allergies in children and babies is to be sure that the developing child has each an ...
The protective effect of breast-feeding on asthma and allergy has been debated for more than 60 years without any hope of a con ...
This study compared the diagnostic value of intradermal tests and patch tests in 20 patients with non-immediate reactions to penicillin (none had IgE antibodies to benzylpenicillin or amoxicillin detectable using a commercial RAST [radioallergosorbent test] method), using 30 patients tolerant to penicillin as controls. Intradermal tests assessed reactivity to injection of major and minor determinants of benzylpenicillin, amoxicillin and ampicillin. Allergy patch testing involved the same hapten solutions used for intradermal testing, either embedded in a patch disk or mixed with petrolatum. (more…)
Suspected drug allergy is not easy to investigate. In the UK, few centers have the necessary facilities and expertise, the evid ...
Patients (and many doctors) frequently use the term ‘allergy’ when referring to any adverse drug reaction, even one that has no fea ...
One of the popular allergy testing besides food allergy testing is skin allergy testing. Allergy patch test is the most commo ...
Allergy skin testing is probably the most susceptible and practical way to monitor for existing allergy sensitivity. Biological ...
Over the last 5 years some studies have suggested that the atopy patch test (APT) may be a useful test in atopic dermatitis childre ...
Suspected drug allergy is not easy to investigate. In the UK, few centers have the necessary facilities and expertise, the evidence base of the available diagnostic tests is not robust, and their interpretation of drug allergy reaction is not straightforward. This has led many clinicians increasingly to rely on the patient’s recollection of previous response to individual allergies medicines when anticipating the likely tolerability of future exposure. (more…)
This study compared the diagnostic value of intradermal tests and patch tests in 20 patients with non-immediate reactions to pe ...
Patients (and many doctors) frequently use the term ‘allergy’ when referring to any adverse drug reaction, even one that has no fea ...
One of the popular allergy testing besides food allergy testing is skin allergy testing. Allergy patch test is the most commo ...
Allergy skin testing is probably the most susceptible and practical way to monitor for existing allergy sensitivity. Biological ...
Over the last 5 years some studies have suggested that the atopy patch test (APT) may be a useful test in atopic dermatitis childre ...
Systemic allergic reactions are a relatively common clinical emergency. In their mildest form, they may just manifest as systemic cutaneous reactions with pruritis, allergy urticaria and angioedema. In more severe cases there are cardiorespiratory symptoms such as stridor, wheeze, difficulty in breathing or hypotension. Anaphylaxis has been defined as a ‘severe, life-threatening generalized or systemic hypersensitivity reaction’. The prevalence of systemic allergic reactions is unclear because of the lack of a clear, consistent definition and large prospective population studies. (more…)
Anaphylactic reactions to Hymenoptera venom are relatively uncommon but can be life-threatening: venom immunotherapy is the treatme ...
Definitions of anaphylaxis vary considerably, impeding the comparison of different clinical studies. Different definitions of a ...
It will be helpful for you to have some understanding of the terms that are currently being used by practitioners in the field ...
The safety of immunotherapy has been a constraint on this form of treatment for allergic disease. Although retrospective survey ...
Families frequently do not use their self-injectable adrenaline device, even when their kids is experiencing a potentially life ...