Allergen-specific immunotherapy is highly effective in the treatment of IgE-mediated allergy diseases such as rhinitis, conjunctivitis, asthma, and venom allergy hypersensitivity. It is the only treatment that leads to lifelong tolerance against previously disease-causing allergens due to restoration of the normal immunity. (more…)
Allergen-specific immunotherapy aims to correct the underlying immune imbalance associated with specific immunotherapy allergic rhi ...
Histamine is a low-molecular-weight monoamine that binds to four different G-protein-coupled receptors, and has recently been d ...
The precise mechanisms underlying the effects of Specific Immunotherapy are not well understood but several studies have shown ...
Treg cells or regulatory T cells constitute a large population of cellular infiltrate in atopic/allergic inflammation and a dys ...
The immunologic mechanisms of sublingual immunotherapy are less established. In Cochrane analysis, the authors concluded that t ...
Normally present at very low levels in plasma, antibodies of the immunoglobulin E (IgE) isotype were first discovered in 1967, decades after the description of IgA, IgG, and IM. IgE antibodies are produced primarily by plasma cells in mucosal-associated lymphoid tissue and their levels are uniformly elevated in patients suffering from atopic conditions like allergic rhinitis, asthma and atopic dermatitis. Production of allergen-specific IgE in atopic individuals is driven both by a genetic predisposition to the synthesis of this isotype as well as by environmental factors, including chronic allergen exposure. (more…)
The precise mechanisms underlying the effects of Specific Immunotherapy are not well understood but several studies have shown ...
Our current knowledge for trigger factor and food allergy intolerance is still in it infancy level. We already known that the aller ...
Treatment with omalizumab has been shown to reduce serum free IgE concentrations and to have beneficial effects on allergic airway ...
A paradigm of immune development underlies allergy development and progression in early childhood. Briefly, the immune system o ...
IgE plays an important role in allergic asthma. Reducing IgE in the airway mucosa should reduce airway inflammation. Omalizumab has ...
This study compared the diagnostic value of intradermal tests and patch tests in 20 patients with non-immediate reactions to penicillin (none had IgE antibodies to benzylpenicillin or amoxicillin detectable using a commercial RAST [radioallergosorbent test] method), using 30 patients tolerant to penicillin as controls. Intradermal tests assessed reactivity to injection of major and minor determinants of benzylpenicillin, amoxicillin and ampicillin. Allergy patch testing involved the same hapten solutions used for intradermal testing, either embedded in a patch disk or mixed with petrolatum. (more…)
Suspected drug allergy is not easy to investigate. In the UK, few centers have the necessary facilities and expertise, the evid ...
Patients (and many doctors) frequently use the term ‘allergy’ when referring to any adverse drug reaction, even one that has no fea ...
One of the popular allergy testing besides food allergy testing is skin allergy testing. Allergy patch test is the most commo ...
Allergy skin testing is probably the most susceptible and practical way to monitor for existing allergy sensitivity. Biological ...
Over the last 5 years some studies have suggested that the atopy patch test (APT) may be a useful test in atopic dermatitis childre ...
Being an immunological disease, the characteristics of allergy are those of specificity and memory. Regardless of whether the clinical manifestation is rhinoconjunctivitis, rhinitis, or asthma, the underlying immunological response disorder is based on the adverse reactions of cells in the immune system upon contact with allergens. These cells are specific for epitopes that are structural parts of allergens present in the allergenic source material. Two types of cells (i.e., T cells and B-cells) produce receptor molecules (i.e., T-cell receptors and immunoglobulin [IgE] antibodies) that, through high-affinity interactions with the allergen, efficiently catalyze the presence of even minute amounts of allergens into clinical symptoms, the extreme consequence of which may be life-threatening to the patient. (more…)
Allergen vaccines are complex mixtures of antigenic components produced by the extraction of naturally occurring source materia ...
The production of allergen vaccines imposes a number of constraints on both the selection of source materials and the physicoch ...
The quality of an allergen vaccine is a measure of the complexity of the composition, including the concentration of the variou ...
The potency of an allergen vaccine is the total allergen activity (that is, the sum of the contribution to allergenic activity from ...
Having determined an adequate potency and complexity in composition, an allergen vaccine may still be deficient in the content of m ...
A paradigm of immune development underlies allergy development and progression in early childhood. Briefly, the immune system of the fetus is maintained in a tolerogenic state, preventing adverse immune responses and rejection between the mother and fetus. Placental interleukin-10 (IL-10) suppresses the production of immune-potentiating inter-feron gamma (IFN-y) by fetal immune cells. IFN-y downregulates the production of pro-allergic cytokines, such as IL-4 and IL-13. (more…)
In the Tucson CRS study, about 50% of young children experienced a period of recurrent wheezing and/or coughing in the first 6 ...
Treatment with omalizumab has been shown to reduce serum free IgE concentrations and to have beneficial effects on allergic airway ...
The precise mechanisms underlying the effects of Specific Immunotherapy are not well understood but several studies have shown ...
Recently, UK Department of Health has circulated advice aimed at reducing the development of peanut allergy. The advice, base ...
Exposure and allergic sensitization to cockroach was associated with a significantly greater risk of asthma hospitalization and ...
Systemic allergic reactions are a relatively common clinical emergency. In their mildest form, they may just manifest as systemic cutaneous reactions with pruritis, allergy urticaria and angioedema. In more severe cases there are cardiorespiratory symptoms such as stridor, wheeze, difficulty in breathing or hypotension. Anaphylaxis has been defined as a ‘severe, life-threatening generalized or systemic hypersensitivity reaction’. The prevalence of systemic allergic reactions is unclear because of the lack of a clear, consistent definition and large prospective population studies. (more…)
Anaphylactic reactions to Hymenoptera venom are relatively uncommon but can be life-threatening: venom immunotherapy is the treatme ...
Definitions of anaphylaxis vary considerably, impeding the comparison of different clinical studies. Different definitions of a ...
It will be helpful for you to have some understanding of the terms that are currently being used by practitioners in the field ...
The safety of immunotherapy has been a constraint on this form of treatment for allergic disease. Although retrospective survey ...
Families frequently do not use their self-injectable adrenaline device, even when their kids is experiencing a potentially life ...
Cow’s milk is the most frequently encountered food allergen in infancy, and milk allergy is often the earliest indicator that a baby is atopic. Precise figures of the incidence of cow’s milk allergy are hard to find because of the difficulties in obtaining an accurate diagnosis, differences in the populations used for research studies, and disagreement about allergy symptoms (clinical criteria) for the condition. All studies agree, however, that cow’s milk allergy is most prevalent in early childhood with an incidence of 2 to 7.5 percent being reported. (more…)
Cow’s milk is the most frequently encountered food allergen in infancy, and milk allergy is often the earliest indicator that a ...
Cow’s milk allergy results when antibodies against milk allergens are produced by the immune system. Milk allergens are p ...
How frequently do you drink milk everyday or every week? Feel something strange after you drink your last milk? Perhaps you don ...
If the breast-fed baby is lactose intolerant (usually a temporary condition following intestinal infection at this age), moth ...
Terms Indicating the Presence of Cow’s Milk Components Butter, Butter fat, Butter-flavored oil, Butter solids, Whipped but ...
At least a million Spanish suffer allergic reactions to food, some of them as common as milk, eggs, fruit or fish. Many of them are children who are constrained in their quality of life and opportunities to participate in activities as usual for other children and enjoy a family meal, eating at school, have a pizza or a bagel or even attend a children’s party. An accidental ingestion of a food to which you are allergic (which happens often due to lack of identification of many food allergy ingredients) can have serious consequences, from allergic urticaria to anaphylaxis symptoms. (more…)
It is quite likely you've known someone with a severe allergy. From peanuts to gluten, such food allergies have grown to be much mo ...
A cross-sectional, descriptive, questionnaire-based survey was conducted in schools in Toulouse, France, to determine the preva ...
Food allergies represent a hard challenge to maintain weight loss in when you are frequently eating out in restaurant. Last s ...
Many people will tell you that they have a food allergy; in fact in today's society it is considered to be trendy, with celebri ...
Having a food intolerance test is becoming increasingly popular nowadays. This is because the symptoms of indigestion, stomach ...
The two strongest risk factors for asthma in childhood are a family history and immediate hypersensitivity to common allergens. This immune response includes both IgE antibodies and helper T cells type 2 (Th2), both of which are thought to contribute to the inflammation in the respiratory tract. Children with asthma who mount an immune response to inhalant allergens have an increased risk of developing asthma because of this combination of genetics and exposure. However, it is sensitization to indoor allergens (e.g. dust mites, cats, dogs, and cockroaches) that is strongly associated with asthma. (more…)
Exposure and allergic sensitization to cockroach was associated with a significantly greater risk of asthma hospitalization and ...
There is much controversy as to the role of allergen exposure for the development of atopic sensitization towards this allergen. Wh ...
Classification of bronchial asthma can be based on age, etiology, associated characteristics, or severity. Classifications base ...
Sensitization to pets remains a risk factor for asthma and rhinitis, and can occur in people who have never lived with a pet. S ...
This population-based cross-sectional study, funded by a UK government agency, aimed to establish the rate of sensitization to food ...
Cow’s milk allergy results when antibodies against milk allergens are produced by the immune system.
Milk allergens are proteins; more than 25 distinct milk proteins have been identified in the various fractions of milk. The fractions include casein, whey, serum, and certain additional ingredients. (more…)
Cow’s milk is the most frequently encountered food allergen in infancy, and milk allergy is often the earliest indicator that ...
Cow’s milk is the most frequently encountered food allergen in infancy, and milk allergy is often the earliest indicator that a ...
How frequently do you drink milk everyday or every week? Feel something strange after you drink your last milk? Perhaps you don ...
Terms Indicating the Presence of Cow’s Milk Components Butter, Butter fat, Butter-flavored oil, Butter solids, Whipped but ...
If the breast-fed baby is lactose intolerant (usually a temporary condition following intestinal infection at this age), moth ...