Two long-acting ß 2 -adrenergic agonists (LABAs), salmeterol and formoterol, have been demonstrated to be safe and effective agents in children, both in terms of bronchodilation and prevention of exercise-induced bronchospasm. Their onsets of action differ, with formoterol having an onset similar to albuterol (3 minutes), while salmeterol has a slower onset of action (10–20 minutes). Following a single-dose administration, both agents demonstrate durations of action up to 12 hours. Following regular twice-daily administration, bronchodilation remains effective; however, a level of tolerance (or tachyphylaxis) (more…)
For most patients, asthma is not controlled as defined by guidelines; whether this is achievable has not been prospectively stu ...
This study evaluated budesonide formoterol efficacy and safety of a novel asthma management strategy for both maintenance and s ...
Asthma control is improved by combining inhaled corticosteroids with long acting beta-agonists but patients still require relie ...
Regular use of ß-agonists has been known to lead to tolerance to their bronchodilator effects. It is not known how quickly toleranc ...
Current internationally recognized guidelines indicate that symptomatic asthmatics using a low to medium inhaled corticosteroid ...
Cromolyn sodium and nedocromil sodium are inhaled agents that are alternatives to inhaled corticosteroids (ICS) in the management of mild persistent asthma in children. Both drugs have been shown to possess anti inflammatory properties through nonsteroidal mechanisms, although the exact mechanisms for their actions remain unclear. (more…)
Roflumilast is an oral, once-daily PDE4 inhibitor with antiinflammatory activity in development for the treatment of asthma. Ro ...
Two long-acting ß 2 -adrenergic agonists (LABAs), salmeterol and formoterol, have been demonstrated to be safe and effective ag ...
Exercise-induced asthma is a feeling of shortness of breath, with the presence of cough, wheezing, and chest tightness after physic ...
Maintenance of asthma control by once-daily inhaled ciclesonide nasal spray in adults with persistent asthma. Ciclesonide is an ...
Up to 85% of asthmatics patients have symptoms of wheezing during or after exercise. Moreover, many patients diagnosed with all ...
Roflumilast is an oral, once-daily inhibitor of phosphodiesterase type 4 (PDE4) that prevents the breakdown of cyclic adenosine monophosphate (cAMP) levels, leading to inhibition of pro-inflammatory signalling. This study investigated the effects of repeated doses of 250 or 500 µg of roflumilast on airway asthma responses to allergen. (more…)
Roflumilast is an oral, once-daily PDE4 inhibitor with antiinflammatory activity in development for the treatment of asthma. Ro ...
Marimastat is a synthetic broad-spectrum matrix metalloproteinase (MMP) inhibitor. This study assessed the anti-inflammatory effect ...
Treating allergic rhinitis may have a downstream effect on concomitant asthma and this may be due to attenuation of the underlying ...
Tumour Necrosis Factor is a pro-inflammatory cytokine implicated in the pathogenesis of asthmatic airway inflammation, hyper-react ...
Despite optimum drug delivery and good compliance with inhaled corticosteroids, many patients experience symptoms and exacerbat ...
Regular use of ß-agonists has been known to lead to tolerance to their bronchodilator effects. It is not known how quickly tolerance develops or how long it lasts after stopping ß-agonist therapy.
Bronchodilator tolerance occurs after even a single dose and reaches a maximum after 1 week of regular formoterol. Sensitivity recovers 3 days after stopping treatment. (more…)
This study evaluated budesonide formoterol efficacy and safety of a novel asthma management strategy for both maintenance and s ...
Two long-acting ß 2 -adrenergic agonists (LABAs), salmeterol and formoterol, have been demonstrated to be safe and effective ag ...
Asthma control is improved by combining inhaled corticosteroids with long acting beta-agonists but patients still require relie ...
This study was similar to the study of Harrison and colleagues, which looked at doubling the dose of inhaled corticosteroid dur ...
Current internationally recognized guidelines indicate that symptomatic asthmatics using a low to medium inhaled corticosteroid ...
It is widely knowt that pollen, pollution, smoke can trigger an asthma attack. But one interesting thing is exercise can also trigger asthma reactions.
Yes, because normally we breathe through the nose, where air is filtered, warmed and moistened. But when we exercise, especially if we are colds, sinusitis or allergic rhinitis have “breathe through the mouth and the air gets colder and drier the lungs and also unfiltered, so it can carry more allergens (more…)
Up to 85% of asthmatics patients have symptoms of wheezing during or after exercise. Moreover, many patients diagnosed with all ...
This article focuses on symptoms of exercise induced asthma. Exercise can be a trigger factor when asthma is not well control ...
A history of cough, dyspnea, wheezing, chest tightness or performance problems during exercise suggests the person may have Exercis ...
Asthma treatment has one main goal to maintain a normal and healthy lifestyle, including exercise and other physical activities. Pe ...
Exercise-induced asthma is a feeling of shortness of breath, with the presence of cough, wheezing, and chest tightness after physic ...
Up to 85% of asthmatics patients have symptoms of wheezing during or after exercise. Moreover, many patients diagnosed with allergies or asthma have family allergy history and bronchospasm. Bronchospasm or a bronchial spasm is a sudden constriction of the muscles in the walls of the bronchioles. Bronchospasm is one of the condition or tightness of the airways caused by exercise. (more…)
Exercise-induced asthma is a feeling of shortness of breath, with the presence of cough, wheezing, and chest tightness after physic ...
It is widely knowt that pollen, pollution, smoke can trigger an asthma attack. But one interesting thing is exercise can also trigg ...
A history of cough, dyspnea, wheezing, chest tightness or performance problems during exercise suggests the person may have Exercis ...
Asthma treatment has one main goal to maintain a normal and healthy lifestyle, including exercise and other physical activities. Pe ...
This article focuses on symptoms of exercise induced asthma. Exercise can be a trigger factor when asthma is not well control ...
Many children are living with asthma. Asthma is a lung disease because the constriction of small airways (bronchioles). When this happens, there is moderate to severe difficulty in breathing came with by wheezing. Even though wheezing is not always heard but most of the time it is always present. (more…)
After long-term avoidance of the offending foods, many children outgrow their food allergies. Subsequent periodic challenge wit ...
Having a food intolerance test is becoming increasingly popular nowadays. This is because the symptoms of indigestion, stomach ...
Childhood is the period of life when allergies to food are most prevalent. Food allergy is much more common in babies and young ...
If you suspect that certain foods trigger wheezing or asthma symptoms in your child, your first action should be a consultation ...
The food eating challenges materials used at different centers vary considerably. Some centers use freeze-dried foods, some use con ...
How to properly make clinical diagnosis of acute severe asthma? There is little doubt of the accuracy of current asthma testing. This is because most patients had bring out an established asthma diagnosis from prior regular asthma treatment, before presenting it to Asthma Emergency Department. We can see that most of patients had physical presentation: sitting up right, had profusely diaphoretic, only manage to speak only a few words at a time, and obvious respiratory distress. We can see varying respiratory rate on most patients. Hyperventilating is common in proportion to the severity of asthma attack. On the other hand, patients with hypoventilation is an indication of impending respiratory arrest. (more…)
The role of oral and inhaled corticosteroids in the management of acute asthma is well known. This study compared the effects of in ...
In 2004, there were 2.4 million children aged 5 to 14 years, or 5.9% of this population group, with a self-reported asthma atta ...
Asthma is a frightening condition. I have lived with asthma symptoms for 17 years and the thought of an allergy induced asthma atta ...
Vocal cord dysfunction (VCD) is a functional respiratory tract disorder resulting from paradoxical adduction of the vocal cords ...
This study evaluated budesonide formoterol efficacy and safety of a novel asthma management strategy for both maintenance and s ...