CD14 is part of the receptor complex for endotoxin, which is a component of tobacco smoke. The CD14 gene is located on chromosome 5q, a region previously demonstrated to be linked to asthma when stratified for smoke exposure. This study was designed to extend these findings by determining whether polymorphisms in the CD14 gene are related to this gene–environment interaction on asthma. Puerto Rican (n = 362 trios) and Mexican (n = 259 trios) families ascertained through a child with asthma were studied. (more…)
This study sought to determine the influence of passive exposure to tobacco smoke during childhood on the results of genetic linkag ...
The Tcell Ig domain and mucin domain (TIM) proteins, the genes for which are located on chromosome 5q, have been suggested to b ...
Although ADAM33 was the first gene identified by positional cloning to underlie the risk factor of asthma, attempts to replicate th ...
A previous genome-wide screen for mite-sensitive atopic dermatitis asthma in Japanese families indicated linkage to chromosome 5q33 ...
Increasing evidence demonstrates that cytokines of Th1 and Th2 cells play important roles in allergic disorders. This study exa ...
Avoidance of any one of the individual risk factors associated with childhood asthma has not been successful in preventing its development. The purpose of this study was to determine the effectiveness of a multifaceted intervention programme for the primary prevention of asthma in high-risk infants at 7 years of age. Five hundred and forty-five high-risk infants with an immediate family history of asthma and allergies were prospectively randomized into intervention and control groups pre-natally. (more…)
The authors investigated whether environmental control during pregnancy and early life affects sensitization and lung function at t ...
Two factors thought to influence the risk factor asthma are the promoting effect of sensitization to house dust mites and the preve ...
The prevalence of atopic dermatitis is increasing in Western societies. The hygiene hypothesis proposes that this is due to red ...
To prevent the development of allergy, allergen avoidance has to be instituted before sensitization has occurred. The specific ...
Exposure to allergens plays a role in the development of BHR and in the chronic inflammatory response seen in asthmatic patients. R ...
There is increasing evidence relating body mass index to the prevalence of asthma and incidence of asthma in children and adults, males, and more consistently, in adolescent females. It is unlikely that the association is attributable to reverse causation, i.e. that asthma and obesity because of exercise-induced asthma symptoms. Rather, weight gain can antedate the development of asthma. Weight reduction among asthmatic patients can also result in improvements of lung function. (more…)
There have been concurrent increases in the prevalence of obesity and asthma in recent years in New Zealand and other countries ...
Asthma as disease affects approximately 15 million people in the United States alone. Asthma affected 70 percent more women tha ...
Breast milk contains a variety of bioactive substances, among them soluble CD14 (sCD14), which plays an important role in innat ...
The most important aspect of managing food allergies in children and babies is to be sure that the developing child has each an ...
The protective effect of breast-feeding on asthma and allergy has been debated for more than 60 years without any hope of a con ...
Breast milk contains a variety of bioactive substances, among them soluble CD14 (sCD14), which plays an important role in innate immunity. The authors analysed data of a large prospective birth cohort study to examine the determinants of sCD14 in breast milk, and investigated whether breast-feeding practice and sCD14 concentrations in breast milk are determinants of the risk of Atopic Dermatitis and asthma in children. Eight hundred and three mothers and their newborn infants were included in this analysis. (more…)
The prevalence of atopic dermatitis is increasing in Western societies. The hygiene hypothesis proposes that this is due to red ...
The protective effect of breast-feeding on asthma and allergy has been debated for more than 60 years without any hope of a con ...
Atopic Dermatitis is considered to be one of the first manifestations in the atopic march. The aim of this study was to investi ...
If the breast-fed baby is lactose intolerant (usually a temporary condition following intestinal infection at this age), moth ...
If an exclusively breast-fed baby is exhibiting the type of allergic to milk symptoms previously discussed, the mother will i ...
Asthma and allergic diseases are common in both children and adults. Their development depends on an interaction between asthma genetic and asthma environmental risk factors. Genetic manipulation in multi factorial diseases such as asthma is not feasible in the foreseeable future. However, theoretically, environmental exposures can be controlled in an attempt to stem the rising prevalence of these diseases (primary prevention). Environmental exposures may also influence the frequency of symptoms and the requirement for medication in those with established disease. (more…)
Two factors thought to influence the risk factor asthma are the promoting effect of sensitization to house dust mites and the preve ...
To prevent the development of allergy, allergen avoidance has to be instituted before sensitization has occurred. The specific ...
Avoidance of any one of the individual risk factors associated with childhood asthma has not been successful in preventing its deve ...
Allergen exposure plays a role in the development of asthma bronchial hyper-responsiveness and in the acute inflammatory response ...
Exposure to allergens plays a role in the development of BHR and in the chronic inflammatory response seen in asthmatic patients. R ...
Atopic dermatitis is a chronic inflammatory condition of the skin which usually starts in infancy. It is sometimes called ‘atopic eczema’ or even simply ‘eczema’. Recently, the term ‘atopic eczema dermatitis syndrome’ or eczema symptoms or infantile eczema has also been proposed to indicate the varied nature of this disease. The diagnosis is based on clinical features of a chronic itchy dermatitis with typical morphology and distribution and a relapsing and remitting course. (more…)
Atopic Dermatitis is a chronic relapsing skin disease. Several investigations concerning the long-term prognosis of Atopic Derm ...
Atopic Dermatitis is considered to be one of the first manifestations in the atopic march. The aim of this study was to investi ...
The prevalence of atopic dermatitis is increasing in Western societies. The hygiene hypothesis proposes that this is due to red ...
The pharmacokinetics of pimecrolimus cream 1% and tacrolimus ointment 0.1% in adults with extensive, moderate to severe atopic ...
Topical corticosteroids are the usual therapy for patients with atopic dermatitis, but prolonged use can result in skin atrophy ...
The protective effect of breast-feeding on asthma and allergy has been debated for more than 60 years without any hope of a consensus. A major problem is the lack of randomized controlled trials. However, breast-feeding has a number of other benefits and should be recommended irrespective of any effect on asthma or allergy. This is why randomized trials are not considered ethical. Thus, we have to rely on observational studies, which have produced conflicting results. Mothers who do or do not breastfeed differ in several environmental exposures, including socio-economic class, smoking and area of living, which influence indoor and outdoor exposure to pollutants. Despite statistical adjustment for these confounding factors, the evidence is never as robust as it would be with an randomized controlled trial. (more…)
Breast milk contains a variety of bioactive substances, among them soluble CD14 (sCD14), which plays an important role in innat ...
The prevalence of atopic dermatitis is increasing in Western societies. The hygiene hypothesis proposes that this is due to red ...
The prevalence of asthma increases with increasing levels of Dichlorodiphenyldichloroethylene (DDE). However, the effect of early-l ...
If the breast-fed baby is lactose intolerant (usually a temporary condition following intestinal infection at this age), moth ...
Avoidance of any one of the individual risk factors associated with childhood asthma has not been successful in preventing its deve ...
Cow’s milk is the most frequently encountered food allergen in infancy, and milk allergy is often the earliest indicator that a baby is atopic. Precise figures of the incidence of cow’s milk allergy (CMA) are hard to find because of the difficulties in obtaining an accurate diagnosis, differences in the populations used for research studies, and disagreement about the symptoms (clinical criteria) for the condition. (more…)
Cow’s milk is the most frequently encountered food allergen in infancy, and milk allergy is often the earliest indicator that ...
Cow’s milk allergy results when antibodies against milk allergens are produced by the immune system. Milk allergens are p ...
How frequently do you drink milk everyday or every week? Feel something strange after you drink your last milk? Perhaps you don ...
If the breast-fed baby is lactose intolerant (usually a temporary condition following intestinal infection at this age), moth ...
Over the last 5 years some studies have suggested that the atopy patch test (APT) may be a useful test in atopic dermatitis childre ...
Recently, UK Department of Health has circulated advice aimed at reducing the development of peanut allergy. The advice, based on an expert-committee report, is that pregnant women “may wish” to avoid eating peanuts or foods containing peanut products if they or the father or siblings of the unborn child are atopic. The same advice is given for the lactation period.
Are your children having peanut allergies? If yes, and you are new to this things, you are advised to look for some guidance. ...
A paradigm of immune development underlies allergy development and progression in early childhood. Briefly, the immune system o ...
A better detection, the least restrictive health food allergies choices, specific measures of allergy prevention, and teaching ...
Asthma and allergic diseases are common in both children and adults. Their development depends on an interaction between asthma ...
A cross-sectional, descriptive, questionnaire-based survey was conducted in schools in Toulouse, France, to determine the preva ...