Two long-acting ß 2 -adrenergic agonists (LABAs), salmeterol and formoterol, have been demonstrated to be safe and effective agents in children, both in terms of bronchodilation and prevention of exercise-induced bronchospasm. Their onsets of action differ, with formoterol having an onset similar to albuterol (3 minutes), while salmeterol has a slower onset of action (10–20 minutes). Following a single-dose administration, both agents demonstrate durations of action up to 12 hours. Following regular twice-daily administration, bronchodilation remains effective; however, a level of tolerance (or tachyphylaxis) (more…)
For most patients, asthma is not controlled as defined by guidelines; whether this is achievable has not been prospectively stu ...
This study evaluated budesonide formoterol efficacy and safety of a novel asthma management strategy for both maintenance and s ...
Asthma control is improved by combining inhaled corticosteroids with long acting beta-agonists but patients still require relie ...
Regular use of ß-agonists has been known to lead to tolerance to their bronchodilator effects. It is not known how quickly toleranc ...
Current internationally recognized guidelines indicate that symptomatic asthmatics using a low to medium inhaled corticosteroid ...
Maintenance of asthma control by once-daily inhaled ciclesonide nasal spray in adults with persistent asthma. Ciclesonide is an inhaled corticosteroid that is converted to an active metabolite, desisobutyryl ciclesonide, in the lungs, thereby minimizing effects on endogenous cortisol inflammation. The goal of finding newer, safer corticosteroids for the management of asthma has led to the development of this inhaled corticosteroid.
This 12-week, double-blind, randomized, parallel-group, placebo-controlled study evaluated the efficacy and safety of ciclesonide in adults with persistent asthma. Efficacy was monitored with asthma symptom scores, rescue medication use, morning and evening peak expiratory flow rate (PEF) measurements, spirometry, and the probability of study completion without experiencing lack of efficacy. It was concluded that ciclesonide (160 or 640 µg) once daily in the morning maintains asthma control effectively, does not affect cortisol levels, and has an adverse event profile comparable with that of placebo in adults with primarily mild to moderate asthma.
It has been reported previously that, compared with fluticasone, ciclesonide possesses equivalent anti-inflammatory efficacy, through pulmonary activation, with a significantly improved safety profile. Since it has low bioavailability because it is metabolized by the lung, it is believed to cause minimal systemic adverse effects. It was found that the morning peak expiratory flow rate (PEF) and FEV 1 values from patient diaries decreased significantly in patients switched from their usual inhaled corticosteroids therapy to placebo but remained stable in patients switched to either dose of ciclesonide (160 or 640 µg). Furthermore, in patients switched to placebo there were significant increases in daily asthma symptoms and the use of rescue medication, with no significant changes from baseline in patients switched to either dose of ciclesonide. Mean changes from baseline in serum and urinary cortisol levels were not statistically significant in any of the treatment groups. Adverse effects were mild, with no reported cases of oral candidiasis.
In conclusion, once-daily inhaled ciclesonide nasal spray (160 or 640 µg) was superior to placebo in the maintenance of asthma control in adult patients previously treated with moderate doses of inhaled corticosteroids, without any significant adverse effects.
The new corticosteroid ciclesonide has been evaluated in various studies to assess its efficacy and adverse effect profile in a ...
This study was similar to the study of Harrison and colleagues, which looked at doubling the dose of inhaled corticosteroid dur ...
The guidelines for asthma management recommend the use of regular inhaled corticosteroid in patients with mild persistent asthma, b ...
Roflumilast is an oral, once-daily PDE4 inhibitor with antiinflammatory activity in development for the treatment of asthma. Ro ...
Patients with severe persistent asthma who are inadequately controlled despite Global Initiative for Asthma (GINA) 2002 step 4 ther ...
Two factors thought to influence the risk factor asthma are the promoting effect of sensitization to house dust mites and the preventive effect of increased omega-3 fatty acids. Although the avoidance of house dust mites allergen has been used as a preventive strategy in several trials, the effect of omega-3 fatty acid supplementation in the primary prevention of asthma and allergic disease is not known. (more…)
To prevent the development of allergy, allergen avoidance has to be instituted before sensitization has occurred. The specific ...
Asthma and allergic diseases are common in both children and adults. Their development depends on an interaction between asthma ...
Allergen exposure plays a role in the development of asthma bronchial hyper-responsiveness and in the acute inflammatory response ...
Exposure to allergens plays a role in the development of BHR and in the chronic inflammatory response seen in asthmatic patients. R ...
Avoidance of any one of the individual risk factors associated with childhood asthma has not been successful in preventing its deve ...
The specific treatment of allergy has previously relied upon allergen avoidance and sublingual immunotherapy. These approaches have been used predominantly in hymenoptera venom and aero-allergen-driven disease when previous food allergy immunotherapy has been unsuccessful. (more…)
The precise mechanisms underlying the effects of Specific Immunotherapy are not well understood but several studies have shown ...
Allergen-specific immunotherapy aims to correct the underlying immune imbalance associated with specific immunotherapy allergic rhi ...
Histamine is a low-molecular-weight monoamine that binds to four different G-protein-coupled receptors, and has recently been d ...
Allergen-specific immunotherapy is highly effective in the treatment of IgE-mediated allergy diseases such as rhinitis, conjunc ...
The increasing prevalence of allergic disease in the Western world has led to the concept of the ‘allergic march’ to describe t ...
Asthma and allergic diseases are common in both children and adults. Their development depends on an interaction between asthma genetic and asthma environmental risk factors. Genetic manipulation in multi factorial diseases such as asthma is not feasible in the foreseeable future. However, theoretically, environmental exposures can be controlled in an attempt to stem the rising prevalence of these diseases (primary prevention). Environmental exposures may also influence the frequency of symptoms and the requirement for medication in those with established disease. (more…)
Two factors thought to influence the risk factor asthma are the promoting effect of sensitization to house dust mites and the preve ...
To prevent the development of allergy, allergen avoidance has to be instituted before sensitization has occurred. The specific ...
Avoidance of any one of the individual risk factors associated with childhood asthma has not been successful in preventing its deve ...
Allergen exposure plays a role in the development of asthma bronchial hyper-responsiveness and in the acute inflammatory response ...
Exposure to allergens plays a role in the development of BHR and in the chronic inflammatory response seen in asthmatic patients. R ...
Asthma as disease affects approximately 15 million people in the United States alone. Asthma affected 70 percent more women than men. One way to help ease asthmatic symptoms is by eating healthy and variety of foods that give your body a few health benefits. If these foods are healthy, so your body is. The vitamins, minerals and nutrients strengthen your body, so that the body functions efficiently and effectively. (more…)
Asthma can be the result of many different things. A lot of the causes can be from genetics. If both parents have asthma, the c ...
At health food stores, customers are complaining about food allergies more often now with statements like, "I can't eat this", or " ...
Food is essential for sustaining human life. Many love to eat and find enjoyment in this activity. But there are literally thou ...
The most important aspect of managing food allergies in children and babies is to be sure that the developing child has each an ...
Many people affected with celiac disease have no idea what's going on until they have gone through years of painful diarrhea, b ...
Discovering natural treatment for allergies is still the main goal for a growing number of people suffering from allergies. At the moment, most of them are depend heavily on allergy pills and allergy drugs. More than often the side effect of this allergy medication are causing something that are worse than the allergy itself.
Allergies occur due to continuously exposure to allergens. (more…)
Sinusitis is one inconvenience disease condition that many people had. Many drugs and antibiotics that are prescribed by your docto ...
If you have a mold allergy, gluten allergy, or had any other type of allergy, then you need to learn natural allergy treatments ...
Allergens are the trigger for human body allergic reaction. It is one of human immunological process to react for invader subst ...
Many medicines that are common and consumed by us everyday was discovered in its natural state. It then process and then synthe ...
Allergies can be defined as inappropriate immune system reactions to a foreign substance entering body. Allergies are kind of disea ...
A better detection, the least restrictive health food allergies choices, specific measures of allergy prevention, and teaching guidelines on potential new therapies has known to improve the management of food allergies. This new approaches give hope to more than twelve million Americans who are affected by food allergy. (more…)
How frequently do you drink milk everyday or every week? Feel something strange after you drink your last milk? Perhaps you don ...
If an exclusively breast-fed baby is exhibiting the type of allergic to milk symptoms previously discussed, the mother will i ...
A cross-sectional, descriptive, questionnaire-based survey was conducted in schools in Toulouse, France, to determine the preva ...
Food is essential for sustaining human life. Many love to eat and find enjoyment in this activity. But there are literally thou ...
Many people will tell you that they have a food allergy; in fact in today's society it is considered to be trendy, with celebri ...
Food allergies are becoming popular topics in the news at the moment. Based on a recent report by the CDC, the number of people with food allergies has grown 20 percent in the last ten years. Only three percent of Americans could correctly distinguish four of the common list of food allergens (peanuts, dairy products, eggs and wheat). But still the main problem is on how to identify food allergies easily? (more…)
Having a food intolerance test is becoming increasingly popular nowadays. This is because the symptoms of indigestion, stomach ...
It is quite likely you've known someone with a severe allergy. From peanuts to gluten, such food allergies have grown to be much mo ...
Many people will tell you that they have a food allergy; in fact in today's society it is considered to be trendy, with celebri ...
Do you have a food allergy? A recent study by the U.S. government has concluded that data from the past on food allergy was not ...
At health food stores, customers are complaining about food allergies more often now with statements like, "I can't eat this", or " ...
Oral allergy syndrome has been most often reported in people who have respiratory allergy (such as hay fever) to specific plant pollens. The pollens most often implicated are produced by :
• Birch and alder trees
• Ragweed (more…)
Oral allergy syndrome is one form of allergy that body have allergic reaction to fruits and vegetables. Based on statistics fa ...
The oral allergy syndrome is difficult to detect. Common allergy tests to examine allergy are using extracts only in skin scrat ...
The diagnostic approach to allergic food reactions comprises three steps. The first step includes the medical allergy history, ...
A cross-sectional, descriptive, questionnaire-based survey was conducted in schools in Toulouse, France, to determine the preva ...
After long-term avoidance of the offending foods, many children outgrow their food allergies. Subsequent periodic challenge wit ...