Allergen-specific immunotherapy is highly effective in the treatment of IgE-mediated allergy diseases such as rhinitis, conjunctivitis, asthma, and venom allergy hypersensitivity. It is the only treatment that leads to lifelong tolerance against previously disease-causing allergens due to restoration of the normal immunity. (more…)
Allergen-specific immunotherapy aims to correct the underlying immune imbalance associated with specific immunotherapy allergic rhi ...
Histamine is a low-molecular-weight monoamine that binds to four different G-protein-coupled receptors, and has recently been d ...
The precise mechanisms underlying the effects of Specific Immunotherapy are not well understood but several studies have shown ...
Treg cells or regulatory T cells constitute a large population of cellular infiltrate in atopic/allergic inflammation and a dys ...
The immunologic mechanisms of sublingual immunotherapy are less established. In Cochrane analysis, the authors concluded that t ...
Two factors thought to influence the risk factor asthma are the promoting effect of sensitization to house dust mites and the preventive effect of increased omega-3 fatty acids. Although the avoidance of house dust mites allergen has been used as a preventive strategy in several trials, the effect of omega-3 fatty acid supplementation in the primary prevention of asthma and allergic disease is not known. (more…)
To prevent the development of allergy, allergen avoidance has to be instituted before sensitization has occurred. The specific ...
Asthma and allergic diseases are common in both children and adults. Their development depends on an interaction between asthma ...
Allergen exposure plays a role in the development of asthma bronchial hyper-responsiveness and in the acute inflammatory response ...
Exposure to allergens plays a role in the development of BHR and in the chronic inflammatory response seen in asthmatic patients. R ...
Avoidance of any one of the individual risk factors associated with childhood asthma has not been successful in preventing its deve ...
Asthma and allergic diseases are common in both children and adults. Their development depends on an interaction between asthma genetic and asthma environmental risk factors. Genetic manipulation in multi factorial diseases such as asthma is not feasible in the foreseeable future. However, theoretically, environmental exposures can be controlled in an attempt to stem the rising prevalence of these diseases (primary prevention). Environmental exposures may also influence the frequency of symptoms and the requirement for medication in those with established disease. (more…)
Two factors thought to influence the risk factor asthma are the promoting effect of sensitization to house dust mites and the preve ...
To prevent the development of allergy, allergen avoidance has to be instituted before sensitization has occurred. The specific ...
Avoidance of any one of the individual risk factors associated with childhood asthma has not been successful in preventing its deve ...
Allergen exposure plays a role in the development of asthma bronchial hyper-responsiveness and in the acute inflammatory response ...
Exposure to allergens plays a role in the development of BHR and in the chronic inflammatory response seen in asthmatic patients. R ...
Natural history studies with the following design features provide a firm epidemiologic foundation for risk factor assessments and etiologic hypotheses:
(1) long-term cohort studies of a prospective design minimize biases resulting from poor parental recall;
(2) multiple evaluations over time provide important checkpoints during the dynamic period of childhood growth and development; and
(3) the inclusion of objective disease measurements strengthens these studies by validating subjective disease assessments (i.e. questionnaire data). (more…)
Atopic Dermatitis is considered to be one of the first manifestations in the atopic march. The aim of this study was to investi ...
In the Tucson CRS study, about 50% of young children experienced a period of recurrent wheezing and/or coughing in the first 6 ...
There is much controversy as to the role of allergen exposure for the development of atopic sensitization towards this allergen. Wh ...
Sensitization to pets remains a risk factor for asthma and rhinitis, and can occur in people who have never lived with a pet. S ...
Avoidance of any one of the individual risk factors associated with childhood asthma has not been successful in preventing its deve ...
Atopic dermatitis is a chronic inflammatory condition of the skin which usually starts in infancy. It is sometimes called ‘atopic eczema’ or even simply ‘eczema’. Recently, the term ‘atopic eczema dermatitis syndrome’ or eczema symptoms or infantile eczema has also been proposed to indicate the varied nature of this disease. The diagnosis is based on clinical features of a chronic itchy dermatitis with typical morphology and distribution and a relapsing and remitting course. (more…)
Atopic Dermatitis is a chronic relapsing skin disease. Several investigations concerning the long-term prognosis of Atopic Derm ...
Atopic Dermatitis is considered to be one of the first manifestations in the atopic march. The aim of this study was to investi ...
The prevalence of atopic dermatitis is increasing in Western societies. The hygiene hypothesis proposes that this is due to red ...
The pharmacokinetics of pimecrolimus cream 1% and tacrolimus ointment 0.1% in adults with extensive, moderate to severe atopic ...
Topical corticosteroids are the usual therapy for patients with atopic dermatitis, but prolonged use can result in skin atrophy ...
An allergic patient’s history may point the clinician’s assessment to a specific area or organ system during allergy testing. In general, physical examination may be standard; shortage of findings isn’t going to rule out allergy.
Essential indicators are a starting point in any physical examination of allergic patients. Respiratory rate is essential as well, but hyperventilation is more a representation of minute ventilation (respiratory rate × tidal volume) than respiratory rate on it’s own. (more…)
Otitis media with effusion is a chronic inflammatory disease of the middle ear space characterized by the accumulation of fluid. P ...
Atopic Dermatitis is a chronic relapsing skin disease. Several investigations concerning the long-term prognosis of Atopic Derm ...
Topical corticosteroids are the usual therapy for patients with atopic dermatitis, but prolonged use can result in skin atrophy ...
Topical corticosteroids are the usual therapy for patients with atopic dermatitis, but prolonged use can result in skin atrophy ...
Asthma is a complex syndrome rather than a single disease entity. Different phenotypes with varying prognosis and determinants have ...
Antihistamines have been shown to be effective in seasonal allergic rhinitis and chronic idiopathic urticaria. They improve quality of life scores, acute inflammatory response markers in atopic dermatitis asthma and symptom scores. Newer histamine H1-receptor antagonists may also have an antiplatelet-activating factor effect and are equally effective in seasonal allergic rhinitis. The antileukotrienes were developed in the 1980s. The first compounds of this novel class of anti-asthma drugs were registered in the second half of the 1990s. The mechanism of action of the cysteinyl leukotriene receptor antagonists (LTRAs) is based on counteracting the effects of cysteinyl leukotrienes at their receptor site (CysLT1 receptor) within the airways. (more…)
A variety of proinflammatory cells, mediators, and cytokines orchestrate the development of airway hyperresponsiveness, which r ...
Montelukast has proven efficacy in the treatment of chronic asthma and seasonal allergic rhinitis, but it has not been evaluate ...
Leukotrienes can be found in the airway and urine following both spontaneous exacerbations of asthma and acute exposure to bron ...
Two main strategies have been developed to block the effects of cysteinyl leukotrienes in the airway. One method is to use drug ...
A role for Leukotriene B4 in the induction of airway hyper-responsiveness was explored through the use of transgenic mice defic ...
The incidence of allergy and asthma is rising. On the other hand, primary care physicians have dealt with allergic conditions far more often than they may expect even before the recent increase in allergic reactions and conditions. Some examples of immunological disease that the primary care physician sees include asthma, allergic rhinitis, and atopic dermatitis.
Bellow are 10 important facts about allergies, common symptoms, treatment and specific allergen.
- The American Academy of Allergy, Asthma and Immunology (AAAAI) estimates that 40 to 50 million people in the United States suffer from allergies.
- Many plants carry pollens that can trigger allergies, but ragweed is the most common. In fact, 75 percent of people with seasonal allergy symptoms are allergic to ragweed, according to the Asthma and Allergy Foundation of America (AAFA).
- The primary treatment for any allergy is avoidance, or refraining from contact with the triggering allergen. Though many allergy drugs can help alleviate the symptoms of an allergic reaction, only avoidance can completely prevent an allergy from occurring.
- While indoor allergies and allergens are not usually seasonal like many types of outdoor allergens, late summer usually sees higher levels of dust mites (due to higher humidity), molds and some pollens (which can be tracked indoors or brought in on clothes).
- The airborne waste created by dust mites is the source of most dust allergies. Dust mites are microscopic arachnids (spiders) one-third of a millimeter long that live indoors in household dust. Between 100 and 500 dust mites typically inhabit a single gram of dust, though in some cases the number can soar to 19,000.
Allergies can be defined as inappropriate immune system reactions to a foreign substance entering body. Allergies are kind of disea ...
Each year, millions of people are susceptible to seasonal allergies symptoms. The pollen of the flowers float in the air that could ...
It is quite likely you've known someone with a severe allergy. From peanuts to gluten, such food allergies have grown to be much mo ...
Food allergies are becoming popular topics in the news at the moment. Based on a recent report by the CDC, the number of people ...
Allergens are the trigger for human body allergic reaction. It is one of human immunological process to react for invader subst ...