CD14 is part of the receptor complex for endotoxin, which is a component of tobacco smoke. The CD14 gene is located on chromosome 5q, a region previously demonstrated to be linked to asthma when stratified for smoke exposure. This study was designed to extend these findings by determining whether polymorphisms in the CD14 gene are related to this gene–environment interaction on asthma. Puerto Rican (n = 362 trios) and Mexican (n = 259 trios) families ascertained through a child with asthma were studied. (more…)
This study sought to determine the influence of passive exposure to tobacco smoke during childhood on the results of genetic linkag ...
The Tcell Ig domain and mucin domain (TIM) proteins, the genes for which are located on chromosome 5q, have been suggested to b ...
Although ADAM33 was the first gene identified by positional cloning to underlie the risk factor of asthma, attempts to replicate th ...
A previous genome-wide screen for mite-sensitive atopic dermatitis asthma in Japanese families indicated linkage to chromosome 5q33 ...
Increasing evidence demonstrates that cytokines of Th1 and Th2 cells play important roles in allergic disorders. This study exa ...
Avoidance of any one of the individual risk factors associated with childhood asthma has not been successful in preventing its development. The purpose of this study was to determine the effectiveness of a multifaceted intervention programme for the primary prevention of asthma in high-risk infants at 7 years of age. Five hundred and forty-five high-risk infants with an immediate family history of asthma and allergies were prospectively randomized into intervention and control groups pre-natally. (more…)
The authors investigated whether environmental control during pregnancy and early life affects sensitization and lung function at t ...
Two factors thought to influence the risk factor asthma are the promoting effect of sensitization to house dust mites and the preve ...
The prevalence of atopic dermatitis is increasing in Western societies. The hygiene hypothesis proposes that this is due to red ...
To prevent the development of allergy, allergen avoidance has to be instituted before sensitization has occurred. The specific ...
Exposure to allergens plays a role in the development of BHR and in the chronic inflammatory response seen in asthmatic patients. R ...
The prevalence of atopic dermatitis is increasing in Western societies. The hygiene hypothesis proposes that this is due to reduced exposure to environmental allergens and infections during early life. The authors examined factors associated with a diagnosis of atopic dermatitis at 3.5 years of age, especially those factors implicated by the hygiene hypothesis. The Auckland Birthweight Collaborative study is a case–control study of risk factors for small-for-gestational-age babies. Cases were born at term with birth weight at or below the 10th centile; controls were appropriate for gestational age, with birth weight above the 10th centile. (more…)
Atopic Dermatitis is considered to be one of the first manifestations in the atopic march. The aim of this study was to investi ...
Breast milk contains a variety of bioactive substances, among them soluble CD14 (sCD14), which plays an important role in innat ...
Atopic Dermatitis is a chronic relapsing skin disease. Several investigations concerning the long-term prognosis of Atopic Derm ...
Avoidance of any one of the individual risk factors associated with childhood asthma has not been successful in preventing its deve ...
Atopic dermatitis is a chronic inflammatory condition of the skin which usually starts in infancy. It is sometimes called ‘atop ...
The protective effect of breast-feeding on asthma and allergy has been debated for more than 60 years without any hope of a consensus. A major problem is the lack of randomized controlled trials. However, breast-feeding has a number of other benefits and should be recommended irrespective of any effect on asthma or allergy. This is why randomized trials are not considered ethical. Thus, we have to rely on observational studies, which have produced conflicting results. Mothers who do or do not breastfeed differ in several environmental exposures, including socio-economic class, smoking and area of living, which influence indoor and outdoor exposure to pollutants. Despite statistical adjustment for these confounding factors, the evidence is never as robust as it would be with an randomized controlled trial. (more…)
Breast milk contains a variety of bioactive substances, among them soluble CD14 (sCD14), which plays an important role in innat ...
The prevalence of atopic dermatitis is increasing in Western societies. The hygiene hypothesis proposes that this is due to red ...
The prevalence of asthma increases with increasing levels of Dichlorodiphenyldichloroethylene (DDE). However, the effect of early-l ...
If the breast-fed baby is lactose intolerant (usually a temporary condition following intestinal infection at this age), moth ...
Avoidance of any one of the individual risk factors associated with childhood asthma has not been successful in preventing its deve ...