Tumour necrosis factor alpha (TNF-a) is a major therapeutic target in a range of chronic inflammatory disorders involving neutrophils and its excess production is characterized by a Th1-type immune response. Asthma is regarded as a Th2-type disorder when associated with atopy, (more…)
Tumour Necrosis Factor is a pro-inflammatory cytokine implicated in the pathogenesis of asthmatic airway inflammation, hyper-react ...
Roflumilast is an oral, once-daily inhibitor of phosphodiesterase type 4 (PDE4) that prevents the breakdown of cyclic adenosine ...
IgE plays an important role in allergic asthma. Reducing IgE in the airway mucosa should reduce airway inflammation. Omalizumab has ...
Lidocaine is a local anaesthetic that possesses the ability to potently shorten eosinophil survival. This study assessed the sa ...
An emerging concept is that pro-inflammatory signals lead to loss of Regulatory T Cells (Treg) function. Pasare and Medzhitov ( ...
Lidocaine is a local anaesthetic that possesses the ability to potently shorten eosinophil survival. This study assessed the safety and efficacy of nebulized lidocaine in a randomized, placebo-controlled study in patients with mild to moderate asthma.
Fifty subjects were recruited (18 male and 32 female) to receive lidocaine (25) or placebo (25). All the subjects had a pre-bronchodilator FEV 1 of 60–125% of the predicted normal value and were treated daily with inhaled glucocorticoids (but not systemic glucocorticoids) and bronchodilators for at least 2 months. (more…)
Tumour necrosis factor alpha (TNF-a) is a major therapeutic target in a range of chronic inflammatory disorders involving neutr ...
Anticholinergic agents, including nebulized glycopyrrolate, a potent but non-selective muscarinic receptor blocker, have been f ...
Maintenance of asthma control by once-daily inhaled ciclesonide nasal spray in adults with persistent asthma. Ciclesonide is an ...
Leukotrienes can be found in the airway and urine following both spontaneous exacerbations of asthma and acute exposure to bron ...
Treating allergic rhinitis may have a downstream effect on concomitant asthma and this may be due to attenuation of the underlying ...