Our understanding of hematopoiesis has advanced greatly in recent years with the isolation and characterization of hematopoietic stem cells (HSCs) and the identification of many of the factors that influence the production and differentiation of lineage-committed progenitors (Figure 1 bellow). HSCs are defined by their abilities to self-renew throughout life and to give rise to committed progenitors that can differentiate along all of the possible hematopoietic lineages. They were first purified from mice as a tiny sub-population of marrow cells that could completely reconstitute the hematopoietic systems of other mice, whose own marrows had been destroyed by inherited mutations or by radiation. (more…)
The process by which blood cells grow, divide, and differentiate in the bone marrow is called hematopoiesis. Three general cl ...
Hematopoietic progenitors depend on a variety of cytokines to control their growth and differentiation. These include several d ...
Although it is commonly imagined that hematopoiesis takes place in a liquid environment resembling the blood, with progenitors resp ...
The Ras-dependent pathway can be triggered by a variety of cytokine receptors, as well as by certain adhesion molecules and by ...
Neutrophils make up an army of more-or-less identical circulating phagocytes that are poised to respond quickly and in vast numbers ...
The manifestations of asthma and allergy are the result of both genetic predisposition and environmental factors. This relationship between genes and the environment is complex and has been the subject of intense investigation in recent years. The predisposition to asthma, unlike that to diseases determined by a single gene, is genetically complex. Consequently, it is thought that a number of genes, each with a relatively small contribution, collectively produce an individual’s genetic susceptibility profile. (more…)
The genetics of asthma will be discussed only in the context of environmental exposures. In general, the identification of nove ...
Although ADAM33 was the first gene identified by positional cloning to underlie the risk factor of asthma, attempts to replicate th ...
A previous genome-wide screen for mite-sensitive atopic dermatitis asthma in Japanese families indicated linkage to chromosome 5q33 ...
Allergic rhinitis and asthma are common comorbidities. Like asthma, the presence of a genetic component in allergic rhinitis ha ...
The Tcell Ig domain and mucin domain (TIM) proteins, the genes for which are located on chromosome 5q, have been suggested to b ...
Many people are under impression that allergy and asthma disease had genetic or heredity factors playing major role as medium of transferred. If parents have allergy, then there is a big chances that their kids will and soon develop allergy in some stage of their live. Some even elaborate this heredity factors to other closed family relatives. (more…)
Children in the early of their life is prone to allergy because their body immune system is not developed completely. As a matter o ...
Hay fever affects millions of people around the world every year. And one of the most common and prolific triggers is grass pol ...
There are still many people that are giving consultation to others, suggest the wrong advice in the context of the treatment of bab ...
Our current knowledge for trigger factor and food allergy intolerance is still in it infancy level. We already known that the aller ...
Allergic reactions is natural body’s response to “foreign substance” or “invader” that potentially harmful to your body. Once ...