The cross-sensitivity between aspirin and Non Steroidal Anti Inflammatory Drugs in patients who manifest pseudo-allergic reactions to aspirin affecting the respiratory tract occurs because Non Steroidal Anti Inflammatory Drugs, like aspirin, inhibit COX-1, so that arachidonic acid metabolism is diverted towards the 5-lipoxygenase pathway, with resulting increased production of cysteinyl leukotrienes, which mediate the appearance of symptoms such as allergic rhinitis and asthma. Selective inhibitors of Cyclo-Oxygenase-2 or COX-2 were developed primarily to reduce the incidence of adverse events affecting the gastrointestinal tract symptoms, but the possibility that these agents might be less likely to result in other varieties of adverse reaction dependent on COX-1 inhibition has attracted interest. This review examined the evidence for their greater safety in this respect. (more…)
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) as one of the popular pain reliever is among regular aspirin, ibuprofen (Advil a ...
This study compared the diagnostic value of intradermal tests and patch tests in 20 patients with non-immediate reactions to pe ...
Suspected drug allergy is not easy to investigate. In the UK, few centers have the necessary facilities and expertise, the evid ...
Patients (and many doctors) frequently use the term ‘allergy’ when referring to any adverse drug reaction, even one that has no fea ...
The prevalence of aspirin-sensitive asthma is uncertain although it may exist in up to 20% of all asthmatics patients. The char ...
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) as one of the popular pain reliever is among regular aspirin, ibuprofen (Advil and Motrin) and naproxen sodium (Aleve). Another kind of pain reliever those are popular as analgesic is acetametaphin (Tylenol). NSAIDs work by curbing the enzyme cyclooxygenase-1 (COX-1) or cyclooxygenase-2 (COX-2) or both of them at the same time. (more…)
The prevalence of aspirin-sensitive asthma is uncertain although it may exist in up to 20% of all asthmatics patients. The char ...
The cross-sensitivity between aspirin and Non Steroidal Anti Inflammatory Drugs in patients who manifest pseudo-allergic reacti ...
Perhaps one day you have experienced chronic fatigue, insomnia, tender points and pain in your muscle all over your body? Do no ...
Allergy and asthma are surrounding many of us. People suffer from various allergy and asthma that are caused by food, dust, and ...
Asthma is a frightening condition. I have lived with asthma symptoms for 17 years and the thought of an allergy induced asthma atta ...