Asthma Genetic and Gene-Environment Interaction in Asthma Development

asthma genetics
The genetic basis of asthma heritability has been extensively studied and the studies are yielding some understanding. There is, as yet, no set genetic pattern that predicts presence of asthma or defines it severity. There are usually reasons or risk of asthma factors that makes someone susceptible to asthma and respiratory allergy problems. Asthma doesn’t just happen randomly to anyone without asthma gene factors risk factors.

Let’s consider some asthma risk factors and see how they increase the chance that a individual will have the asthma signs or symptoms of cough, wheezing, as well as shortness of breathing associated with the disease. After determining your personal risk factors for asthma, decide on the ones you can control as well as try to make some lifestyle changes. Avoidance of the risk factors you can control is important in preventing asthma symptoms. While you cannot change your own gender to family history, you can avoid smoking with asthma, breathing polluted air, and obesity. Take control of your asthma by controlling the asthma risk factors. By understanding all of the risk factors, you are able to prevent to control your asthma.

Genetic factors cannot explain the rise in asthma prevalence, morbidity, or mortality. However, a small change in the prevalence of relevant environmental exposures could explain a significant rise in disease prevalence among genetically susceptible individuals. Gene-environment interaction, defined as the co-participation of genetic and environmental factors, is particularly relevant to the etiology of asthma morbidity, especially in individuals who experience a disproportionate burden of environmental exposures. Relevant exposures include smoking, stress, nutritional factors, infections, allergens, and occupational asthma exposures. In addition, racial/ethnic variability in the distribution of genetic polymorphisms can potentially modify the response to pharmacotherapeutic agents, such as the ß 2 -adrenergic receptor. A genetic polymorphism in the ß 2 -adrenergic receptor gene has been associated with asthma severity, as well as with the susceptibility to develop asthma among individuals who smoked.

Childhood asthma happens more frequently in boys than in girls. It is still not known precisely why this occurs even though some experts find a young male’s airway size is small compared to the female’s airway, that may contribute to increased risk of wheezing after a cold or perhaps other viral infection. Around age 20, the ratio of asthma between people is the same. At age 40, more females than men have adult asthma.

The inherited genetic makeup predisposes you to having asthma. In fact, it’s thought that three-fifths of all asthma cases are hereditary. Based on CDC report, if a person has a parent with asthma, there is 3 to 6 times more probably to develop asthma than someone who does definitely not have a parent with asthma.

T-Cell Immunoglobulin Mucin 1 Genetic Variants And Associated With Asthma In An African-American Population

T-Cell Immunoglobulin
The Tcell Ig domain and mucin domain (TIM) proteins, the genes for which are located on chromosome 5q, have been suggested to be involved in allergic disease. This study examined allergies genetic association of sequence variants of the TIM1 and TIM3 genes in an African-American population. Case–control and family based association analyses were performed for three SNPs each in the TIM1 and TIM3 genes, and an insertion/deletion polymorphism in Tcell Ig domain and mucin domain 1. (more…)

How to Eliminate Dust Mites as Asthma Allergy Prevention

dust mites asthma allergy
Do you know that can find dust mites everywhere and in every home? Even though your home is clean, it doesn’t matter, you may still find dust mites. Dust mites are usually the most common type of allergens that can cause asthma and allergies. At one time this type of allergens strike you, you will find difficulties in breathing. (more…)

Allergies and Age - When Likely Allergy to Occur the First Time

Allergies can be defined as inappropriate immune system reactions to a foreign substance entering body. Allergies are kind of diseases of immune system works to react to certain substances called allergens. Normally when a person is exposed to a harmless substance such as pollen, causes the body natural immune system to respond as if the substance is harmful. Some allergies are inherited from their parents or can be gained in environmental exposure. There are several common allergen exposures like mold, animal dander, pollen, dust mites, and many others. (more…)

Allergy and Asthma – Are They Genetically Inherited?

allergy asthma genetical inherited
Many people are under impression that allergy and asthma disease had genetic or heredity factors playing major role as medium of transferred. If parents have allergy, then there is a big chances that their kids will and soon develop allergy in some stage of their live. Some even elaborate this heredity factors to other closed family relatives. (more…)

Food Allergy Reactions: Triggers and Sources

food allergy reactions

In theory, any kind of food is having the capability to trigger food allergic reaction in our body. All foods contain molecules capable of triggering a response of the immune system. However, for many reasons—including both the structure of the food molecules and our body’s immunological responses—the foods that cause the majority of allergic reactions tend to be few in number. (more…)