Two factors thought to influence the risk factor asthma are the promoting effect of sensitization to house dust mites and the preventive effect of increased omega-3 fatty acids. Although the avoidance of house dust mites allergen has been used as a preventive strategy in several trials, the effect of omega-3 fatty acid supplementation in the primary prevention of asthma and allergic disease is not known. (more…)
To prevent the development of allergy, allergen avoidance has to be instituted before sensitization has occurred. The specific ...
Asthma and allergic diseases are common in both children and adults. Their development depends on an interaction between asthma ...
Allergen exposure plays a role in the development of asthma bronchial hyper-responsiveness and in the acute inflammatory response ...
Exposure to allergens plays a role in the development of BHR and in the chronic inflammatory response seen in asthmatic patients. R ...
Avoidance of any one of the individual risk factors associated with childhood asthma has not been successful in preventing its deve ...
The mediators released by mast cells and basophils can be grouped into two categories:
(1) preformed substances contained within granules and
(2) newly generated chemicals synthesized following cellular activation.
These mediators comprise the effector function of the mast cell. Together they are able to increase vascular permeability, dilate vessels, cause bronchospasm, contract smooth muscle, and summon inflammatory cells. Few cells in the body produce compounds with such a large and varied spectrum of activity. (more…)
The response to injury usually begins with dilatation of small blood vessels in and around the injured site (figure bellow). Th ...
The cysteinyl leukotrienes (LTC 4 , LTD 4 and LTE 4 ) are lipid mediators produced from an arachidonic acid precursor following ...
The precise mechanisms underlying the effects of Specific Immunotherapy are not well understood but several studies have shown ...
Normally present at very low levels in plasma, antibodies of the immunoglobulin E (IgE) isotype were first discovered in 1967, ...
The oral allergy syndrome is difficult to detect. Common allergy tests to examine allergy are using extracts only in skin scrat ...
The cross-sensitivity between aspirin and Non Steroidal Anti Inflammatory Drugs in patients who manifest pseudo-allergic reactions to aspirin affecting the respiratory tract occurs because Non Steroidal Anti Inflammatory Drugs, like aspirin, inhibit COX-1, so that arachidonic acid metabolism is diverted towards the 5-lipoxygenase pathway, with resulting increased production of cysteinyl leukotrienes, which mediate the appearance of symptoms such as allergic rhinitis and asthma. Selective inhibitors of Cyclo-Oxygenase-2 or COX-2 were developed primarily to reduce the incidence of adverse events affecting the gastrointestinal tract symptoms, but the possibility that these agents might be less likely to result in other varieties of adverse reaction dependent on COX-1 inhibition has attracted interest. This review examined the evidence for their greater safety in this respect. (more…)
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) as one of the popular pain reliever is among regular aspirin, ibuprofen (Advil a ...
This study compared the diagnostic value of intradermal tests and patch tests in 20 patients with non-immediate reactions to pe ...
Suspected drug allergy is not easy to investigate. In the UK, few centers have the necessary facilities and expertise, the evid ...
Patients (and many doctors) frequently use the term ‘allergy’ when referring to any adverse drug reaction, even one that has no fea ...
The prevalence of aspirin-sensitive asthma is uncertain although it may exist in up to 20% of all asthmatics patients. The char ...