Allergen-specific immunotherapy is highly effective in the treatment of IgE-mediated allergy diseases such as rhinitis, conjunctivitis, asthma, and venom allergy hypersensitivity. It is the only treatment that leads to lifelong tolerance against previously disease-causing allergens due to restoration of the normal immunity. (more…)
Allergen-specific immunotherapy aims to correct the underlying immune imbalance associated with specific immunotherapy allergic rhi ...
Histamine is a low-molecular-weight monoamine that binds to four different G-protein-coupled receptors, and has recently been d ...
The precise mechanisms underlying the effects of Specific Immunotherapy are not well understood but several studies have shown ...
Treg cells or regulatory T cells constitute a large population of cellular infiltrate in atopic/allergic inflammation and a dys ...
The immunologic mechanisms of sublingual immunotherapy are less established. In Cochrane analysis, the authors concluded that t ...
A variety of proinflammatory cells, mediators, and cytokines orchestrate the development of airway hyperresponsiveness, which results in the episodic airflow obstruction characteristic of asthma. As a consequence, modulation of the underlying disease process with antii-nflammatory agents is firmly established as being the cornerstone of successful management. Inhaled corticosteroids are the most potent antiinflammatory agents available and satisfactorily suppress underlying airway inflammation in most individuals. (more…)
The cysteinyl leukotrienes (LTC 4 , LTD 4 and LTE 4 ) are lipid mediators produced from an arachidonic acid precursor following ...
Antihistamines have been shown to be effective in seasonal allergic rhinitis and chronic idiopathic urticaria. They improve qua ...
In the UK, Europe and the USA, montelukast is licensed for once-daily oral administration in adults and is also available as a ...
Leukotrienes can be found in the airway and urine following both spontaneous exacerbations of asthma and acute exposure to bron ...
Despite optimum drug delivery and good compliance with inhaled corticosteroids, many patients experience symptoms and exacerbat ...
Normally present at very low levels in plasma, antibodies of the immunoglobulin E (IgE) isotype were first discovered in 1967, decades after the description of IgA, IgG, and IM. IgE antibodies are produced primarily by plasma cells in mucosal-associated lymphoid tissue and their levels are uniformly elevated in patients suffering from atopic conditions like allergic rhinitis, asthma and atopic dermatitis. Production of allergen-specific IgE in atopic individuals is driven both by a genetic predisposition to the synthesis of this isotype as well as by environmental factors, including chronic allergen exposure. (more…)
The precise mechanisms underlying the effects of Specific Immunotherapy are not well understood but several studies have shown ...
Our current knowledge for trigger factor and food allergy intolerance is still in it infancy level. We already known that the aller ...
Treatment with omalizumab has been shown to reduce serum free IgE concentrations and to have beneficial effects on allergic airway ...
A paradigm of immune development underlies allergy development and progression in early childhood. Briefly, the immune system o ...
IgE plays an important role in allergic asthma. Reducing IgE in the airway mucosa should reduce airway inflammation. Omalizumab has ...
Montelukast has proven efficacy in the treatment of chronic asthma and seasonal allergic rhinitis, but it has not been evaluated in the subpopulation of asthmatic patients with seasonal asthma symptoms. In patients with chronic asthma and seasonal aeroallergen sensitivity, montelukast treatment provided significant asthma control during the allergy season compared with placebo. (more…)
Treating allergic rhinitis may have a downstream effect on concomitant asthma and this may be due to attenuation of the underlying ...
Despite optimum drug delivery and good compliance with inhaled corticosteroids, many patients experience symptoms and exacerbat ...
Leukotrienes can be found in the airway and urine following both spontaneous exacerbations of asthma and acute exposure to bron ...
Antihistamines have been shown to be effective in seasonal allergic rhinitis and chronic idiopathic urticaria. They improve qua ...
Current internationally recognized guidelines indicate that symptomatic asthmatics using a low to medium inhaled corticosteroid ...
Asthma and allergic diseases are common in both children and adults. Their development depends on an interaction between asthma genetic and asthma environmental risk factors. Genetic manipulation in multi factorial diseases such as asthma is not feasible in the foreseeable future. However, theoretically, environmental exposures can be controlled in an attempt to stem the rising prevalence of these diseases (primary prevention). Environmental exposures may also influence the frequency of symptoms and the requirement for medication in those with established disease. (more…)
Two factors thought to influence the risk factor asthma are the promoting effect of sensitization to house dust mites and the preve ...
To prevent the development of allergy, allergen avoidance has to be instituted before sensitization has occurred. The specific ...
Avoidance of any one of the individual risk factors associated with childhood asthma has not been successful in preventing its deve ...
Allergen exposure plays a role in the development of asthma bronchial hyper-responsiveness and in the acute inflammatory response ...
Exposure to allergens plays a role in the development of BHR and in the chronic inflammatory response seen in asthmatic patients. R ...
Atopic dermatitis is a chronic inflammatory condition of the skin which usually starts in infancy. It is sometimes called ‘atopic eczema’ or even simply ‘eczema’. Recently, the term ‘atopic eczema dermatitis syndrome’ or eczema symptoms or infantile eczema has also been proposed to indicate the varied nature of this disease. The diagnosis is based on clinical features of a chronic itchy dermatitis with typical morphology and distribution and a relapsing and remitting course. (more…)
Atopic Dermatitis is a chronic relapsing skin disease. Several investigations concerning the long-term prognosis of Atopic Derm ...
Atopic Dermatitis is considered to be one of the first manifestations in the atopic march. The aim of this study was to investi ...
The prevalence of atopic dermatitis is increasing in Western societies. The hygiene hypothesis proposes that this is due to red ...
The pharmacokinetics of pimecrolimus cream 1% and tacrolimus ointment 0.1% in adults with extensive, moderate to severe atopic ...
Topical corticosteroids are the usual therapy for patients with atopic dermatitis, but prolonged use can result in skin atrophy ...
An allergic patient’s history may point the clinician’s assessment to a specific area or organ system during allergy testing. In general, physical examination may be standard; shortage of findings isn’t going to rule out allergy.
Essential indicators are a starting point in any physical examination of allergic patients. Respiratory rate is essential as well, but hyperventilation is more a representation of minute ventilation (respiratory rate × tidal volume) than respiratory rate on it’s own. (more…)
Otitis media with effusion is a chronic inflammatory disease of the middle ear space characterized by the accumulation of fluid. P ...
Atopic Dermatitis is a chronic relapsing skin disease. Several investigations concerning the long-term prognosis of Atopic Derm ...
Topical corticosteroids are the usual therapy for patients with atopic dermatitis, but prolonged use can result in skin atrophy ...
Topical corticosteroids are the usual therapy for patients with atopic dermatitis, but prolonged use can result in skin atrophy ...
Asthma is a complex syndrome rather than a single disease entity. Different phenotypes with varying prognosis and determinants have ...
During recent decades there has been extensive epidemiological research to explore the increasing prevalence of asthma and allergy in childhood. The worldwide variations in the prevalence of these diseases necessitate regional rapport. Furthermore, time-trend analyses with comparable methods are important in order to monitor the rapidly changing prevalence of these atopic diseases. Three cross sectional questionnaire-based studies of asthma and allergy in school children were conducted in the counties of Troms and Finnmark in northern Norway in 1985, 1995 and 2000. (more…)
There have been concurrent increases in the prevalence of obesity and asthma in recent years in New Zealand and other countries ...
Atopic Dermatitis is a chronic relapsing skin disease. Several investigations concerning the long-term prognosis of Atopic Derm ...
The geographical variation in the prevalence of asthma in children does not coincide with variations in air pollution levels. The i ...
Asthma is a complex syndrome rather than a single disease entity. Different phenotypes with varying prognosis and determinants have ...
A general pattern of factors influencing development of asthma seems to be emerging, including family allergy history/ asthma g ...
Atopic Dermatitis is a chronic relapsing skin disease. Several investigations concerning the long-term prognosis of Atopic Dermatitis in children and teenagers have been performed but there are few data for adults. The aim of this study was to investigate the prognosis and prognostic factors in adult patients with Atopic Dermatitis using a long-term follow-up (25–38 years). A follow-up questionnaire was sent to 922 Atopic Dermatitis patients examined in an out-patient clinic between 1960 and 1973 among 1366 registered patients with Atopic Dermatitis. The patients were aged 20 years or older when they visited the clinic and 45 years or older when they answered the follow-up questionnaire. (more…)
Atopic Dermatitis is considered to be one of the first manifestations in the atopic march. The aim of this study was to investi ...
The prevalence of atopic dermatitis is increasing in Western societies. The hygiene hypothesis proposes that this is due to red ...
Topical corticosteroids are the usual therapy for patients with atopic dermatitis, but prolonged use can result in skin atrophy ...
Topical corticosteroids are the usual therapy for patients with atopic dermatitis, but prolonged use can result in skin atrophy ...
Atopic dermatitis is a chronic inflammatory condition of the skin which usually starts in infancy. It is sometimes called ‘atop ...
Expert GA ² LEN, the Global Network European Allergy and Asthma European Academy of Allergy and Clinical Immunology, EAACI, warn that the old antihistamines that are sold without a prescription and are the most common form of self-medication for allergic rhinitis triggers can be hazardous to health. (more…)
First-generation, relatively sedating oral H1 antihistamines such as diphenhydramine and chlorpheniramine have no role in the out-o ...
Indoor allergy is generally happens throughout the year and especially in children as they are the most victims of this type of ...
As a person who suffered form allergies and have a profession as family physician, I have much sympathy for those struggling with i ...
Allergen-specific immunotherapy is highly effective in the treatment of IgE-mediated allergy diseases such as rhinitis, conjunc ...
Treatment of allergic diseases in childhood presents unique challenges, as both the beneficial effects and the detrimenta ...