Oral Food Challenges & Relationship to Allergen-Specific IgE Levels

Diagnosis of food hypersensitivity is a clinical challenge and the only current definitive test is the Double Blind Placebo-Controlled Food Challenges. Although the Double Blind Placebo-Controlled Food Challenges is the current gold standard, it is difficult to perform and is very time-consuming. Hence, researchers are continually evaluating new tests and assessing the value of the available serum tests. (more…)

Infection and Atopy in the Pathogenesis of Childhood Asthma

infection atopy childhood asthma
It is clear from the results of large epidemiologic studies that while atopy is a major risk factor for asthma, it is usually not sufficient by itself to drive the disease process to chronicity, as less than 25% of atopics develop persistent asthma. The situation in childhood is further complicated by an additional series of development factors, related to postnatal maturation of respiratory function. (more…)

Gastrointestinal Allergy Symptoms and Food Intolerance

gastrointestinal allergy symptoms
Gastrointestinal allergy can be classified according to the triggering antigen, the mechanism of immune reaction, or the anatomic site of reaction.

Gastrointestinal allergy may be triggered by food components (e.g. food proteins or glycoproteins), and by other antigen antibody reaction to (e.g. bacterial disease, viral, fungal, and worm antigen), drugs and chemicals, (more…)

Drug Allergy Reaction Classification – Immune Reactions

drug allergy reaction
Drug allergy reactions may be classified, at least theoretically, according to one of four implicated immunologic mechanisms, according to the scheme of Gell and Coombs:

Type I Drug Allergy Reactions

Type I reactions are the result of an IgE antibody reaction, which induces immediate-type hypersensitivity reactions. (more…)

Endotoxins and Exotoxins

endotoxins and exotoxins
Exotoxins are noxious proteins secreted by many bacteria. These toxins are often heat-labile and thus can be heat-inactivated for use as vaccines to prevent toxigenic immunity to bacteria disease. Many bacteria produce more than one protein exotoxin, making vaccine development more difficult. (more…)

Current Indications for Specific Immunotherapy

indications immunotherapy
It is now almost a century since the pioneering work of Noon and Freeman was used to successfully treat hay fever symptoms using a low-dose incremental schedule of pollen injections. Noon based his doses of pollen extract on a pollen weight unit that remained in use for over 70 years; (more…)

Oral Allergy Syndrome: Symptoms, Mechanisms, and Reactivity

oral allergy syndrome symptoms
The oral allergy syndrome is difficult to detect. Common allergy tests to examine allergy are using extracts only in skin scratch testing. But this method is quite useless due to many enzymes involved in allergy reaction are already broken out in the process of extraction. They are not as effective as the original enzymes. Oral Allergy Syndrome is usually diagnoses by symptoms that are appeared. The other method is to look for allergy history to pollen, if any. (more…)

Antibodies in Food Sensitivity – IgG Antibody

antibody food sensitivity
It is common to find anti-food IgG antibodies circulating in blood, even in people who have no signs or history of adverse reactions to foods. In fact, some authorities think that an increase in anti-food IgG in some cases might be indicative of successful resolution of an IgE-mediated allergy. The subject of IgG-mediated food allergy is extremely complicated because of the nature of the antibody and the immunological reactions associated with it. The present knowledge about food allergy-associated IgG may be summarized as follows: (more…)

Dietary Management of Oral Allergy Syndrome

oral allergy syndrome
Oral allergy syndrome is one form of allergy that body have allergic reaction to fruits and vegetables. Based on statistics facts, The American Academy of Allergy Asthma and Immunology described that probably one third of people allergic to pollen may can extend and develop to oral allergy syndrome. As a matter of fact, not only pollen and fruits allergy are related, but pollen allergy can lead into the oral allergy to certain fruits and vegetables. (more…)

Management Food Associated Asthma in Children | Asthma Foods to Avoid

asthma foods avoid
After long-term avoidance of the offending foods, many children outgrow their food allergies. Subsequent periodic challenge with asthma foods to avoid, the offending food should therefore be undertaken to determine whether your child remains allergic to it. The results of skin and blood tests tend to remain positive long after symptoms have resolved, so direct challenge with the offending food is usually necessary. (more…)

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