Cromolyn sodium and nedocromil sodium are inhaled agents that are alternatives to inhaled corticosteroids (ICS) in the management of mild persistent asthma in children. Both drugs have been shown to possess anti inflammatory properties through nonsteroidal mechanisms, although the exact mechanisms for their actions remain unclear. (more…)
Roflumilast is an oral, once-daily PDE4 inhibitor with antiinflammatory activity in development for the treatment of asthma. Ro ...
Two long-acting ß 2 -adrenergic agonists (LABAs), salmeterol and formoterol, have been demonstrated to be safe and effective ag ...
Exercise-induced asthma is a feeling of shortness of breath, with the presence of cough, wheezing, and chest tightness after physic ...
Maintenance of asthma control by once-daily inhaled ciclesonide nasal spray in adults with persistent asthma. Ciclesonide is an ...
Up to 85% of asthmatics patients have symptoms of wheezing during or after exercise. Moreover, many patients diagnosed with all ...
Other humoral effectors and humoral factors have the ability to lyse microorganisms directly. The best studied of these are a class of small peptide antibiotics known as defensins, which in their active forms are all roughly 30 amino acids long (3,5 kilodaltons), positively charged, and protease-resistant. Each also has three internal disulfide bonds. They are classified as either α or β defensins based on the arrangement of the disulfides, but both classes have nearly the same compact, folded structure consisting of three strands of antiparallel β-pleated sheets. (more…)
Contact of pathogens with the innate immune system will most frequently occur at epithelia, and the biology of the airway epitheliu ...
The body's innate resistance to many pathogens is provided by enzymes and other proteins in the blood and tissue fluids. These ...
Innate immune responses are seen in a very broad range of tissues. Indeed, the Toll-like receptors (TLRs, one of the most important ...
While our primary concern is the impact that the innate immune system has on allergic disease, it is essential to recognize that al ...
A few of the best known humoral effectors of innate immunity are listed in Table 1 bellow, along with the types of target molec ...
Treating allergic rhinitis may have a downstream effect on concomitant asthma and this may be due to attenuation of the underlying inflammatory process.
Fexofenadine and montelukast exhibited additive effects to moderately high doses of inhaled corticosteroids when used as add-on therapy in the treatment of patients with persistent atopic asthma. (more…)
Despite optimum drug delivery and good compliance with inhaled corticosteroids, many patients experience symptoms and exacerbat ...
The role of oral and inhaled corticosteroids in the management of acute asthma is well known. This study compared the effects of in ...
Montelukast has proven efficacy in the treatment of chronic asthma and seasonal allergic rhinitis, but it has not been evaluate ...
Roflumilast is an oral, once-daily PDE4 inhibitor with antiinflammatory activity in development for the treatment of asthma. Ro ...
Current internationally recognized guidelines indicate that symptomatic asthmatics using a low to medium inhaled corticosteroid ...
Suspected drug allergy is not easy to investigate. In the UK, few centers have the necessary facilities and expertise, the evidence base of the available diagnostic tests is not robust, and their interpretation of drug allergy reaction is not straightforward. This has led many clinicians increasingly to rely on the patient’s recollection of previous response to individual allergies medicines when anticipating the likely tolerability of future exposure. (more…)
This study compared the diagnostic value of intradermal tests and patch tests in 20 patients with non-immediate reactions to pe ...
Patients (and many doctors) frequently use the term ‘allergy’ when referring to any adverse drug reaction, even one that has no fea ...
One of the popular allergy testing besides food allergy testing is skin allergy testing. Allergy patch test is the most commo ...
Allergy skin testing is probably the most susceptible and practical way to monitor for existing allergy sensitivity. Biological ...
Over the last 5 years some studies have suggested that the atopy patch test (APT) may be a useful test in atopic dermatitis childre ...
The most crucial element in the assessment process of a possible allergic problem is patient’s allergy history. An allergy history is made up of a chief problem, resolve of seasonality or diurnal variation of symptoms, detection of triggers, occupational asthma exposure, and reaction to medicines, family history, and some other relevant medical history. An allergy history looks for to define the patient’s chief complaint(s) and concentrates on the details with regards to those complaints. There is a lexicon typical to patients with allergy complaints. Sinus dizziness strain and headaches are often cited as symptoms. The history taker should be attuned to the patient’s viewpoint as a possible allergy sufferer. Exactly where and when does the symptom happen? Or is it happened during sleep? (more…)
Patient’s allergy history is one of the most important elements to evaluate of possible allergic problem. Sometimes this import ...
If you have sinusitis, one of the displeasing aspects of sinusitis is dizziness condition that comes with it. Symptoms of sin ...
Are there any complications with Allergic rhinitis? At first glance, the symptoms of allergic rhinitis may not appear unduly troub ...
Allergy skin testing is probably the most susceptible and practical way to monitor for existing allergy sensitivity. Biological ...
Classification of bronchial asthma can be based on age, etiology, associated characteristics, or severity. Classifications base ...
There is much controversy as to the role of allergen exposure for the development of atopic sensitization towards this allergen. While in some studies, a clear, almost linear dose-response relation between allergen exposure and sensitization has been found, others described a bell-shaped association with higher levels of exposures relating to lower rates of atopic sensitization. Part of the discrepancy may relate to the type of allergen, since mostly cat but not house dust mite allergy allergen exposure has been shown, in some studies, to exert protective effects at higher levels of exposure. (more…)
Natural history studies with the following design features provide a firm epidemiologic foundation for risk factor assessments and ...
The effects of exposure to environmental tobacco smoke (ETS) on children have been extensively studied and numerous surveys hav ...
Two factors thought to influence the risk factor asthma are the promoting effect of sensitization to house dust mites and the preve ...
Allergen exposure plays a role in the development of asthma bronchial hyper-responsiveness and in the acute inflammatory response ...
Sensitization to pets remains a risk factor for asthma and rhinitis, and can occur in people who have never lived with a pet. S ...
Epidemiological studies of farm children are of international interest because farm children are less often atopic disorders, have less allergic disease, and often have less asthma pain than do non-farm children—findings consistent with the hygiene hypothesis. The investigators studied a cohort of rural Iowa children to determine the association between farm and other environmental risk factors with four asthma outcomes: (more…)
A general pattern of factors influencing development of asthma seems to be emerging, including family allergy history/ asthma g ...
Breast milk contains a variety of bioactive substances, among them soluble CD14 (sCD14), which plays an important role in innat ...
There is increasing evidence relating body mass index to the prevalence of asthma and incidence of asthma in children and adult ...
There is much controversy as to the role of allergen exposure for the development of atopic sensitization towards this allergen. Wh ...
According to the National Survey of Children in the United States, the prevalence of asthma was 15% (last 12 months), that of h ...
Are you frustrated because sneezing a lot? The real problem may be right in your face under your nose, literally! Sinus infection or sinusitis is an irritation of the sinuses. Sinuses is the air openings in the bones of the face lined with mucous membranes alongside with nose passage way. The infection in this area leads to suppression of infection in the nasal blockage or nasal allergen, which leads to inflammation of the sinuses. (more…)
I know it is not necessary to inform all of you the misery of sinusitis and several sinus infection problems, it can be. Sinus irri ...
Herbal remedies that are claimed to treat sinusitis are abundant on the market. There are many options when it comes to herbal ...
Sinusitis is one inconvenience disease condition that many people had. Many drugs and antibiotics that are prescribed by your docto ...
If you have sinusitis, one of the displeasing aspects of sinusitis is dizziness condition that comes with it. Symptoms of sin ...
A sinus infection may result in a series of different symptoms. People complain about the feeling of pressure force in the head ...
Patients (and many doctors) frequently use the term ‘allergy’ when referring to any adverse drug reaction, even one that has no features of an IgE-mediated allergy response. However, IgE-mediated allergy explains only about 10% of all adverse reactions to antigen antibody reactions from antibiotics. Patients who have experienced unexplained symptoms during treatment with two or more antibiotics are often said to have ‘multiple antibiotic allergy’; using this definition, the description can be applied to one patient in every 22. (more…)
This study compared the diagnostic value of intradermal tests and patch tests in 20 patients with non-immediate reactions to pe ...
Suspected drug allergy is not easy to investigate. In the UK, few centers have the necessary facilities and expertise, the evid ...
Drug allergy reactions may be classified, at least theoretically, according to one of four implicated immunologic mechanisms, a ...
Allergy skin testing is probably the most susceptible and practical way to monitor for existing allergy sensitivity. Biological ...
One of the popular allergy testing besides food allergy testing is skin allergy testing. Allergy patch test is the most commo ...
Sinusitis is one inconvenience disease condition that many people had. Many drugs and antibiotics that are prescribed by your doctor may take days or weeks to works. If you suffer from sinusitis, seasonal allergic rhinitis or hay fever, this article will be of advantage to treat them with herbal remedies. (more…)
Herbal remedies that are claimed to treat sinusitis are abundant on the market. There are many options when it comes to herbal ...
Are you frustrated because sneezing a lot? The real problem may be right in your face under your nose, literally! Sinus infection o ...
If you have sinusitis, one of the displeasing aspects of sinusitis is dizziness condition that comes with it. Symptoms of sin ...
I know it is not necessary to inform all of you the misery of sinusitis and several sinus infection problems, it can be. Sinus irri ...
Many medicines that are common and consumed by us everyday was discovered in its natural state. It then process and then synthe ...