Acute Phase Proteins Biological and Clinical Importance

Acute phase proteins and the acute phase response in general arc stably conserved in evolution and are universal within each species. They are thus presumably of benefit to the organism undergoing infection, inflammation and/or tissue damage, although much remains to be learned of the properties and functions of many acute phase reactants. On the other hand, sustained, increased production of serum amyloid a Protein (SAA) is a necessary though not sufficient condition for the development of reactive, systemic AA amyloidosis, a grave complication of chronic infection or inflammation. (more…)

Progressive Systemic Sclerosis Scleroderma

systemic sclerosis
Scleroderma is a disease of unknown cause characterized by abnormally increased collagen deposition in the skin. The course is usually slowly progressive and chronically disabling, but it can be rapidly progressive and fatal because of involvement of internal organs. It commonly begins in the third or fourth decade of life, but children are occasionally affected. The prevalence of the disease is one case per 100,000 in the population. Women are affected twice as often as men. There is no racial predisposition. (more…)

Systemic Sclerosis Scleroderma Symptoms and Signs

sclerosis scleroderma
Scleroderma is a disease related with body autoimmune, connective tissue disease. Scleroderma induces inflammation and thickening of the skin. In scleroderma patients, their tissues are diffuse connective tissue disease characterized by changes in the skin, blood vessels, skeletal muscles, and internal organs. (more…)